| Pure Theatre | Charleston | A65 Arts, Culture & Humanities | $713k | 1 |
| Lee County School Facilities Inc | Bishopville | B11 Education | $713k | 0 |
| PHILLIS WHEATLEY ASSOCIATION | Greenville | P20 Human Services | $713k | 1 |
| Horizons Christian Academy | Chester | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $713k | 0 |
| PEE DEE EMERGENCY MEDICAL SERVICES | Florence | — | $712k | 1 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B190 Education | $712k | 0 |
| WORK IN PROGRESS INC | Columbia | F33Z Mental Health & Crisis Intervention | $712k | 0 |
| Montessori School of Pawleys Island | Pawleys Island | B24Z Education | $707k | 1 |
| THE CONWAY CHAMBER OF COMMERCE | Conway | — | $707k | 1 |
| SOUTH CAROLINA ATHLETIC COACHES | Greenwood | — | $707k | 0 |
| HITCHCOCK WOODS FOUNDATION THE | Aiken | C500 Environment | $707k | 0 |
| BLANCHE D KILPATRICK CHARITABLE TA | Charleston | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $706k | 0 |
| Ernest A Finney Jr Cultural Arts Center | Columbia | A25 Arts, Culture & Humanities | $706k | 0 |
| THE GREENWOOD PROMISE LLC | Greenwood | P20 Human Services | $705k | 0 |
| FOUR HOLES INDIAN ORGANIZATION | Ridgeville | P84Z Human Services | $705k | 0 |
| JERRY AND ANITA ZUCKER FAMILY FOUNDATION INC | N Charleston | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $704k | 0 |
| HARBOR HISTORICAL ASSOCIATION | Georgetown | B99 Education | $703k | 0 |
| TRI-COUNTY SPEAKS | Charleston | — | $702k | 0 |
| HUB CITY WRITERS PROJECT | Spartanburg | A70 Arts, Culture & Humanities | $701k | 1 |
| ALSTON WILKES ASSOCIATION | Columbia | Z99Z Unknown | $700k | 0 |
| LEXINGTON COUNTY SOCCER CLUB | Lexington | N64 Recreation & Sports | $699k | 0 |
| THE OUTDOOR DREAM FOUNDATION | Anderson | P20 Human Services | $698k | 0 |
| SOUTH CAROLINA DEFENSE TRIAL ATTORNEYS | Columbia | — | $696k | 0 |
| AMERICAN WATER WORKS ASSOCIATION | Columbia | W038 Public & Societal Benefit | $696k | 1 |
| WINE AND SPIRIT WHOLESALERS ASSOC | Columbia | S40 Community Improvement & Capacity Building | $695k | 1 |
| YOUNG WOMENS CHRISTIAN ASSOCIATION | Sumter | P270 Human Services | $695k | 1 |
| PATH INC | York | — | $694k | 0 |
| THE CENTER FOR FAITHWALK LEADERSHIP | Greer | W70 Public & Societal Benefit | $694k | 0 |
| PLEDGE THE PINK FOUNDATION | Bluffton | G32 Diseases, Disorders & Medical Disciplines | $693k | 0 |
| LONG BAY SYMPHONIC SOCIETY LTD | Myrtle Beach | — | $690k | 1 |
| COME GO WITH US INC | Conway | Q33 International, Foreign Affairs & National Security | $688k | 1 |
| SENIOR CENTERS OF CHEROKEE COUNTY | Gaffney | P81Z Human Services | $687k | 0 |
| THE SUSANNA IACOVELLI CHARITABLE | Greenville | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $686k | 0 |
| THE CHAMPIONS CENTER | Anderson | P82 Human Services | $685k | 0 |
| GA PROPERTIES INC | Greenville | — | $684k | 0 |
| GERMAN RIFLE CLUB OF CHARLESTON | Charleston | — | $684k | 0 |
| A SECOND CHANCE RESOURCE CENTER NETWORK UNITED INC | North Charleston | P50 Human Services | $684k | 0 |
| Columbia Sailing Club | Columbia | — | $684k | 0 |
| COMPETITIVE DREAMS OF YOUTH IN THE CAROLINAS | Rock Hill | A116 Arts, Culture & Humanities | $682k | 5 |
| DISCIPLE CHRISTIAN MC | West Columbia | X20 Religion-Related | $681k | 1 |
| KERSHAW COUNTY COUNCIL ON AGING | Camden | P81Z Human Services | $680k | 0 |
| SOUTH CAROLINA COMMUNITY CAPITAL | Charleston | S30 Community Improvement & Capacity Building | $678k | 0 |
| PROJECT CARE INC | Greenville | L20 Housing & Shelter | $677k | 3 |
| WARRIOR SURF FOUNDATION | Folly Beach | W30 Public & Societal Benefit | $676k | 0 |
| SCIENTIFIC EQUIPMENT AND FURNITURE | Columbia | — | $676k | 0 |
| CHATTOOGA CONSERVANCY | Mountain Rest | C30 Environment | $675k | 1 |
| SC SHARE (SELF-HELP ASSOCIATION | Cayce | — | $674k | 1 |
| SOUTH CAROLINA INSTITUTE OF | Columbia | E70 Health Care | $673k | 1 |
| YWAM MYRTLE BEACH INC | Myrtle Beach | X99 Religion-Related | $672k | 0 |
| LUTHERAN SERVANTS FOR CHRIST | Goose Creek | X20 Religion-Related | $669k | 0 |
