| THE CHILDREN'S RESEARCH AND EDUCATION INSTITUTE INC | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $777k | 2 |
| BIG SHOTS GLOBAL | North Myrtle Beach | — | $777k | 0 |
| Beza Fund Inc | Taylors | Q32 International, Foreign Affairs & National Security | $776k | 0 |
| LCL ROCKSTARS INC | Chester | O19 Youth Development | $776k | 0 |
| SC INTERNATIONAL TRADE CONFERENCE | Mount Pleasant | — | $776k | 0 |
| GOVERNOR'S MANSION FOUNDATION | Columbia | A82Z Arts, Culture & Humanities | $775k | 1 |
| FRATERNUS INC FRATERNUS | Pickens | O50 Youth Development | $773k | 5 |
| Junior League of Columbia Inc | Columbia | — | $773k | 0 |
| PEE DEE EMERGENCY MEDICAL SERVICES | Florence | — | $773k | 1 |
| HOME BUILDERS ASSOCIATION OF SC | Columbia | — | $773k | 1 |
| Bluffton Community Soup Kitchen | Bluffton | P20 Human Services | $773k | 1 |
| THE COMPLETE STUDENT | Port Royal | B24 Education | $772k | 0 |
| DREAMS IMAGINATION & GIFT DEVELOPMENT PROGRAM DIG | Simpsonville | O50 Youth Development | $772k | 1 |
| FEED & SEED CO | Greenville | B60 Education | $771k | 0 |
| Pink & Green Community Service Foundation Inc | Columbia | S20 Community Improvement & Capacity Building | $771k | 0 |
| JUNIOR JAZZ FOUNDATION INC | Hilton Head Island | A60 Arts, Culture & Humanities | $771k | 0 |
| WALLACE WATER COMPANY INCORPORATED | Wallace | — | $770k | 8 |
| GREENVILLE CONNECTS | Greenville | W80 Public & Societal Benefit | $770k | 1 |
| Impact Change | Rock Hill | K30 Food, Agriculture & Nutrition | $769k | 0 |
| LESPRI MINISTRIES | Fort Mill | Q33 International, Foreign Affairs & National Security | $768k | 1 |
| CHAPIN EAGLE CLUB | Chapin | — | $766k | 0 |
| ALSTON WILKES ASSOCIATION | Columbia | Z99Z Unknown | $765k | 0 |
| HILTON HEAD ISLAND FOUNDATION TO SUPPORT YOUTH SPORTS INC | Bluffton | N50 Recreation & Sports | $765k | 1 |
| RIZE Prevention Inc | Simpsonville | — | $765k | 1 |
| IAAM SUPPORT ORGANIZATION | Charleston | A11 Arts, Culture & Humanities | $764k | 6 |
| UNITED MINISTRIES OF CLINTON | Clinton | P20 Human Services | $763k | 1 |
| SIXTH DISTRICT OMEGA PSI PHI FRATERNITY INC | Columbia | — | $763k | 0 |
| HELP OF BEAUFORT | Beaufort | P600 Human Services | $762k | 0 |
| DIGNITY HOUSING ASSOCIATION INC | Columbia | L200 Housing & Shelter | $761k | 0 |
| DARLINGTON COUNTY HABITAT FOR HUMANITY INC | Hartsville | L20Z Housing & Shelter | $760k | 1 |
| JUNIOR LEAGUE OF GREENVILLE INC | Greenville | S810 Community Improvement & Capacity Building | $759k | 1 |
| Museum & Gallery Inc | Greenville | A510 Arts, Culture & Humanities | $759k | 1 |
| HOLY CITY CHRISTIAN ACADEMY | Huger | B24 Education | $758k | 0 |
| FRESHWATER COAST COMMUNITY FOUNDATION | Abbeville | S20 Community Improvement & Capacity Building | $758k | 0 |
| BROOKLAND ACADEMY CHILD DEVELOPMENT CENTER | Columbia | B21 Education | $758k | 1 |
| UPSTATE GREENWAYS AND TRAILS ALLIANCE | Greenville | C01 Environment | $757k | 1 |
| GERMAN RIFLE CLUB OF CHARLESTON | Charleston | — | $757k | 0 |
| WWWPILOTSNPAWSORG INC | Landrum | D20 Animal-Related | $757k | 1 |
| Kanguka | Mount Pleasant | — | $756k | 0 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS LOCAL # 470 | Graniteville | — | $756k | 2 |
| RIVER HILLS EMERGENCY SQUAD INC | Lake Wylie | E620 Health Care | $755k | 3 |
| EMERSON ROSE HEART FOUNDATION | Clemson | E12 Health Care | $755k | 1 |
| JASPER COUNTY COUNCIL ON AGING INC | Ridgeland | P81Z Human Services | $753k | 1 |
| ENOUGH IS ENOUGH | Mount Pleasant | I99Z Crime & Legal-Related | $752k | 2 |
| CHARLESTON AREA THERAPEUTIC RIDING INC | Johns Island | E50Z Health Care | $751k | 1 |
| OSWEGO RURAL WATER COMPANY | Sumter | — | $751k | 1 |
| MCCORMICK COUNTY HOUSING FOR AGINGINC | McCormick | — | $750k | 0 |
| Bethune Rural Water Company Inc | Bethune | — | $750k | 7 |
| THE GOSPEL HOUR INC | Taylors | X20Z Religion-Related | $748k | 1 |
| AMERICAN COUNCIL OF ENGINEERING COMPANIE | Columbia | — | $747k | 0 |
