| COLUMBIA CHILDRENS THEATRE | Columbia | A65 Arts, Culture & Humanities | $472k | 0 |
| HOSPICE CARE FOUNDATION OF THE PIEDMONT | Greenwood | E11 Health Care | $472k | 0 |
| OCEAN VIEW MEMORIAL FOUNDATION INC | Myrtle Beach | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $472k | 0 |
| CATAWBA REGIONAL DEVELOPMENT CORPORATION | Rock Hill | — | $471k | 0 |
| BETHEL CHRISTIAN CAMP AND RETREAT C | Gaston | — | $471k | 0 |
| TRI-COUNTY COMMUNITY FOUNDATION | Barnwell | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $471k | 1 |
| UNITED WAY OF LANCASTER COUNTY INC | Lancaster | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $470k | 0 |
| LAKE WYLIE ATHLETIC ASSOCIATION INC | Clover | N99 Recreation & Sports | $470k | 0 |
| SOLOMONS HOME FOR THE AGED | Sumter | E91Z Health Care | $469k | 0 |
| THE LIVITY FOUNDATION INC | Charleston | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $469k | 1 |
| CAROLINA WILDLIFE CARE INC | Columbia | D340 Animal-Related | $468k | 0 |
| RICHLAND COUNTY COURT APPOINTED SPECIAL ADVOCATES | Columbia | — | $468k | 0 |
| TOTAL MINISTRIES OF SPARTANBURG COUNTY INC | Spartanburg | — | $467k | 1 |
| TOTT SOCIAL CLUB | Clemson | — | $466k | 0 |
| REBEL BAND BOOSTER CLUB | Duncan | A11 Arts, Culture & Humanities | $466k | 0 |
| NATIONAL GUARD ASSOCIATION OF SC | Columbia | W30 Public & Societal Benefit | $466k | 1 |
| PALMETTO GUN CLUB INC | Summerville | — | $466k | 0 |
| BIRTHRIGHT OF GREENVILLE INC | Greenville | — | $464k | 1 |
| PLEASANT GROVE ACADEMY | Marion | B21 Education | $464k | 2 |
| Mill Town Foundation | Fort Mill | O50 Youth Development | $464k | 1 |
| S C HUNTERS AND LANDOWNERS FOR THE HUNGRY | Spartanburg | P40 Human Services | $463k | 0 |
| THE WORKMAN FAMILY CHARITABLE TRUST | Columbia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $463k | 0 |
| WESTVIEW FOUNDATION | Conway | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $462k | 1 |
| YWCA OF GREATER CHARLESTON | Charleston | P27Z Human Services | $462k | 0 |
| CLEMSON ANDERSON SOCCER ALLIANCE | Seneca | N64 Recreation & Sports | $462k | 0 |
| SOUTH CAROLINA ALLIANCE OF YMCAS | Rock Hill | N12 Recreation & Sports | $462k | 1 |
| PAWLEYS ISLAND FESTIVAL OF MUSIC AND ART INC | Pawleys Island | A67Z Arts, Culture & Humanities | $461k | 2 |
| PALMETTO ELECTRIC TRUST | Ridgeland | — | $461k | 0 |
| CLARENCE H & ANNA E LUTZ FOUNDATION | Chester | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $460k | 3 |
| DORN RESEARCH INSTITUTE INC | Columbia | H99Z Medical Research | $460k | 2 |
| C4 MINISTRIES INC | Union | X20 Religion-Related | $460k | 3 |
| RUTH'S GLEANINGS | Spartanburg | P80 Human Services | $459k | 5 |
| SUMMERVILLE ORCHESTRA | Summerville | A69 Arts, Culture & Humanities | $459k | 0 |
| South Carolina Chiropractic Association | Columbia | — | $459k | 0 |
| ORCHARD HOUSE CLUB INC | Sunset | N50 Recreation & Sports | $459k | 0 |
| Silver Lining Arts Foundation Inc | Myrtle Beach | — | $458k | 0 |
| SOUTH CAROLINA ASSOCIATION OF SCHOOL BUSINESS OFFICIALS | Columbia | — | $458k | 2 |
| SIOP FOUNDATION INC | Drayton | B82 Education | $458k | 0 |
| SECOND CHANCE SHOP | Summerville | P29 Human Services | $458k | 0 |
| SOUTH CAROLINA HUMAN SERVICES PROVIDERS INC | Winnsboro | S41 Community Improvement & Capacity Building | $458k | 0 |
| CAREFIRST CAROLINA FOUNDATION | Hartsville | E70 Health Care | $457k | 1 |
| Conway Downtown Alive Inc | Conway | S200 Community Improvement & Capacity Building | $457k | 1 |
| Gullah Geechee Chamber Foundation | Georgetown | P20 Human Services | $457k | 0 |
| HOPE REMAINS YOUTH RANCH INC | Wellford | O50 Youth Development | $457k | 0 |
| PHILLIPS-AMICK FOUNDATION FOR CANCER RESEARCH | Greenville | H30 Medical Research | $457k | 0 |
| Chapin American Legion Post 193 | Chapin | — | $457k | 0 |
| NATIVE ISLAND BUSINESS & COMMUNITY AFFAIRS ASSOCIATION INC | Hilton Head Island | S30 Community Improvement & Capacity Building | $456k | 0 |
| NEW BEGINNING OF CHARLESTON INC | Summerville | F99 Mental Health & Crisis Intervention | $456k | 3 |
| CHATTOOGA LAKE CLUB INC | Mountain Rest | — | $455k | 0 |
| NAVIGATING FROM GOOD TO GREAT FOUNDATION | Columbia | S20 Community Improvement & Capacity Building | $454k | 1 |
