| Palmetto Community Health Care | Rock Hill | E300 Health Care | $426k | 1 |
| HALTER (HEALING AND LEARNING | Spartanburg | — | $426k | 1 |
| PATHWAY MENTAL WELLNESS | Greer | W70 Public & Societal Benefit | $426k | 0 |
| Justice Ministries | Clover | I73 Crime & Legal-Related | $426k | 4 |
| GREENVILLE HURRICANES INC | Greer | N60 Recreation & Sports | $426k | 0 |
| Barnabas Horse Foundation Inc | Murrells Inlet | F60 Mental Health & Crisis Intervention | $424k | 2 |
| CHARLESTON OPERA THEATER INC | Charleston | A6A Arts, Culture & Humanities | $424k | 3 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B012 Education | $424k | 1 |
| CAROLINA WINTER ENSEMBLE ASSOCIATION INC | Rock Hill | O99 Youth Development | $423k | 3 |
| NATIONAL FEDERATION OF THE BLIND OF SC | Columbia | G41Z Diseases, Disorders & Medical Disciplines | $423k | 0 |
| MAGNOLIA CEMETERY TRUST | Charleston | — | $423k | 0 |
| Florence Downtown Development Corporation Inc | Florence | C50 Environment | $422k | 0 |
| AMERICAN LEGION NORTH STRAND POST 186 | Little River | — | $422k | 0 |
| YORK SENIOR PROPERTIES INC | Rock Hill | L22Z Housing & Shelter | $422k | 0 |
| SOUTH CAROLINA ARTS ALLIANCE | Spartanburg | — | $421k | 0 |
| PALMETTO ELECTRIC TRUST | Ridgeland | — | $421k | 0 |
| SWITCH | Greenville | P20 Human Services | $421k | 1 |
| PICKENS COUNTY HUMANE SOCIETY | Liberty | D200 Animal-Related | $421k | 1 |
| SOLOMONS HOME FOR THE AGED | Sumter | E91Z Health Care | $421k | 0 |
| BIBLE WAY CHURCH OF GEORGETOWN | Georgetown | P330 Human Services | $421k | 3 |
| The St James Learning Center | Marion | B11 Education | $420k | 0 |
| Clover High School Band Boosters Club | Clover | B112 Education | $420k | 0 |
| EXCELSIOR ACADEMY | Irmo | B20 Education | $420k | 0 |
| COLLETON COUNTY COUNCIL ON AGING | Walterboro | P81Z Human Services | $420k | 1 |
| PALMETTO FARMS FOUNDATION | Greenville | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $420k | 0 |
| HOLLY SPRINGS CENTER | Pickens | A90 Arts, Culture & Humanities | $419k | 2 |
| AHEPA 284 II INC | Columbia | L20 Housing & Shelter | $418k | 0 |
| TRUST UW OF HC GRAHAM | Marion | — | $418k | 1 |
| THE AIKEN CORPORATION OF SOUTH CAROLINA | Aiken | A65 Arts, Culture & Humanities | $417k | 0 |
| FACES AND VOICES OF RECOVERY TRI-COUNTY INC | Lake Wylie | P20 Human Services | $416k | 1 |
| Palmetto Family Council | Columbia | P20Z Human Services | $415k | 1 |
| Jubilee Academy Inc | Columbia | P80 Human Services | $415k | 1 |
| A Moment of Hope | Columbia | X99 Religion-Related | $414k | 2 |
| LEXINGTON COUNTY SCHOOL DISTRICT | Lexington | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $414k | 0 |
| GREENWOOD COMMUNITY THEATRE INC | Greenwood | A650 Arts, Culture & Humanities | $414k | 0 |
| AMERICAN LEGION POST 166 | Goose Creek | — | $413k | 0 |
| ALPHA SOCCER ACADEMY | Fort Mill | O50 Youth Development | $413k | 2 |
| ABC Crisis Pregnancy Center Inc | Florence | P40 Human Services | $413k | 1 |
| PI KAPPA PHI FRATERNITY SIGMA | Columbia | B83 Education | $412k | 0 |
| OLD TOWN ASSOCIATION | Rock Hill | S20 Community Improvement & Capacity Building | $412k | 0 |
| CAROLINAS COUNCIL OF HOUSING REDEVELOPMENT & CODES OFFICIALS | Marion | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $412k | 0 |
| CARVER APARTMENTS INC | West Columbia | L25 Housing & Shelter | $411k | 0 |
| Coventry Foundation Inc | Columbia | A80 Arts, Culture & Humanities | $411k | 0 |
| Miss Ruby's Kids | Georgetown | B21 Education | $410k | 1 |
| THE CHARLES LEA CENTER FOUNDATION INC | Spartanburg | — | $410k | 1 |
| NOTUS SPORTS | Greenville | N72 Recreation & Sports | $409k | 1 |
| All Things Possible Medical Fundraising | Fort Mill | P50 Human Services | $409k | 2 |
| SOUTH CAROLINA BOATING AND FISHING | Chapin | — | $409k | 1 |
| PERFORMING ARTS AND SCIENCE ACADEMY PASA | Marion | A20 Arts, Culture & Humanities | $409k | 0 |
| FLORENCE AREA HUMANE SOCIETY | Florence | D200 Animal-Related | $408k | 0 |
