| Sea Island Hunger Awareness Foundation | Johns Island | K30 Food, Agriculture & Nutrition | $454k | 0 |
| FLORENCE AREA HUMANE SOCIETY | Florence | D200 Animal-Related | $454k | 0 |
| EVERYBLACKGIRL INC | Columbia | B29 Education | $453k | 1 |
| UNIVERSAL COMMUNITY IMPROVEMENT ORGANIZATION | Irmo | P20 Human Services | $453k | 0 |
| TRI-CITY VISIONARIES INC | Eastover | P20 Human Services | $453k | 0 |
| W C CHRISTIAN CHILD | Summerville | P33 Human Services | $453k | 2 |
| FOUNDATION FOR COMMUNITY IMPACT & HEALTH EQUITY | Ridgeway | E70 Health Care | $452k | 2 |
| BLACK RIVER UNITED WAY INC | Georgetown | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $452k | 1 |
| SHALOM HOUSE MINISTRIES INC | Belton | F20 Mental Health & Crisis Intervention | $451k | 1 |
| ASSOCIATION OF CANCER EXECUTIVES | Charleston | B90 Education | $451k | 0 |
| ORANGEBURG COUNTY FAIR ASSOCIATION | Orangeburg | — | $451k | 0 |
| FAMILY PROMISE OF YORK COUNTYINC | Rock Hill | P85 Human Services | $451k | 1 |
| MSPGEEK INC | Taylors | S40 Community Improvement & Capacity Building | $450k | 0 |
| LCA FOUNDATION | Ridgeland | B90 Education | $450k | 0 |
| SUMTER COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $450k | 0 |
| Palmetto Recovery of Charleston | Charleston | F20 Mental Health & Crisis Intervention | $450k | 2 |
| SOUTH CAROLINA WORKERS' COMPENSATION EDUCATIONAL ASSOCIATIO | Columbia | B60 Education | $449k | 0 |
| Come-See-Me Festival Inc | Rock Hill | W99 Public & Societal Benefit | $449k | 0 |
| Station Eight Insurance Company | Charleston | Y23 Mutual & Membership Benefit | $449k | 0 |
| VETERANS OF FOREIGN WARS OF THE | Isle Of Palms | — | $449k | 0 |
| HELPING HANDS OF GOOSE CREEK INC | Goose Creek | — | $448k | 1 |
| Spartanburg United Soccer Academy | Boiling Springs | N60 Recreation & Sports | $448k | 1 |
| JAMES F BYRNES FOUNDATION | Columbia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $448k | 0 |
| DIXIE HIGH SCHOOL FOUNDATION INC | Due West | B94 Education | $448k | 0 |
| PALMETTO ANIMAL ASSISTED LIFE SERVI | Columbia | P80 Human Services | $448k | 0 |
| CERTIFIED DEVELOPMENT CORPORATION OF SOUTH CAROLINA | Columbia | S31Z Community Improvement & Capacity Building | $447k | 13 |
| HABITAT FOR HUMANITY INTERNATIONAL KERSHAW COUNTY | Camden | — | $447k | 0 |
| AIKEN SYMPHONY ORCHESTRA | Aiken | A69 Arts, Culture & Humanities | $446k | 1 |
| SCHOOL NUTRITION ASSOCIATION OF SC | Columbia | — | $446k | 0 |
| UPSTATE INSTITUTE OF YOUTH PROGRAMS | Seneca | O50 Youth Development | $446k | 3 |
| CHARLESTON SYMPHONY ORCHESTRA LEAGUE INC | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $446k | 0 |
| CHEROKEE CREEK VOLUNTEER FIRE DEPARTMENT INC | Gaffney | M24Z Public Safety, Disaster Preparedness & Relief | $446k | 0 |
| THE VISION INSTITUTE OF SOUTH CAROLINA I | Irmo | — | $446k | 0 |
| PS BAILEY AND OUIDA C BAILEY FOUNDATION | Clinton | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $445k | 0 |
| Foundation for Reproductive Genetics Education Inc | Irmo | B90 Education | $445k | 0 |
| IRONMAN OUTDOOR MINISTRIES INC | Blythewood | X20 Religion-Related | $445k | 1 |
| Pursuit Christian Academy | Effingham | — | $445k | 0 |
| Fletcher Gwaltney Shared Services Inc | Bamberg | E92Z Health Care | $444k | 0 |
| THE HAVEN MEN'S SHELTER | Rock Hill | L41 Housing & Shelter | $444k | 0 |
| Coastal Samaritan Counseling Center | Myrtle Beach | P46Z Human Services | $444k | 2 |
| WASHINGTON LIGHT INFANTRY OF CHARLESTON INC | Charleston | — | $443k | 4 |
| Clover High School Band Boosters Club | Clover | B112 Education | $443k | 0 |
| COLLETON COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | — | $443k | 1 |
| STEPPING STONES MINISTRY INC | Columbia | J32 Employment | $442k | 5 |
| THE MARSHALL MILLER FOUNDATION | Hilton Head Island | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $442k | 0 |
| WHITE HORSE MISSIONS | Fountain Inn | X20 Religion-Related | $442k | 1 |
| SPARTANBURG ART MUSEUM | Spartanburg | — | $442k | 0 |
| ANIMAL SHELTER OF CLARENDON COUNTY INC DBA A SECOND CHANCE ANIMAL SHELTER | Manning | D20 Animal-Related | $441k | 1 |
| CROSSOVER ATHLETICS | Lexington | N60 Recreation & Sports | $440k | 0 |
| SOUTH CAROLINA RAILROAD MUSEUM INC | Columbia | — | $440k | 0 |
