| Focused Living Ministries | Columbia | X21 Religion-Related | $323k | 4 |
| HILTON HEAD ISLAND SWIM TEAM | Hilton Head Island | — | $322k | 1 |
| BOOST BY HINGE | Greenville | P20 Human Services | $322k | 0 |
| South Carolina Association for Educational Technology | Columbia | — | $322k | 0 |
| MYRTLE BEACH HIGH SCHOOL ALL SPORTS BOOSTER CLUB | Myrtle Beach | B112 Education | $322k | 0 |
| Clover Choraliers Booster Club | Clover | A11 Arts, Culture & Humanities | $322k | 0 |
| KNOW2 | Gaffney | O50 Youth Development | $321k | 2 |
| TEACHING-FAMILY ASSOCIATION | Anderson | — | $321k | 0 |
| CHARLES E HARWOOD TRUST C/O JANICE W SINCLAIR - CO-TRUSTEE | Bluffton | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $321k | 2 |
| Edward & Dorothy Kendall Foundation | Eastover | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $321k | 0 |
| MARLBORO COUNTY COUNCIL ON AGING | Bennettsville | P81Z Human Services | $321k | 1 |
| KATIE'S KROPS | Summerville | K30 Food, Agriculture & Nutrition | $321k | 2 |
| YEARGIN FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $320k | 0 |
| Hilton Head Island All Sports Booster Club | Hilton Head | B11 Education | $320k | 1 |
| CAROLINA TEEN CENTER | Summerville | E70 Health Care | $319k | 1 |
| CAROLINA HONDURAS HEALTH FOUNDATION | Conway | E30 Health Care | $319k | 0 |
| GREATER GREENVILLE SCOTTISH GAMES & HIGHLAND FESTIVAL | Greenville | N32 Recreation & Sports | $319k | 0 |
| Ann Brodies Carolina Ballet | Columbia | — | $319k | 1 |
| BLUFFTON RUSH FOUNDATION LLC | Bluffton | N12 Recreation & Sports | $318k | 1 |
| DANIEL-EDWARDS BAND BOOSTERS | Central | B122 Education | $318k | 0 |
| The Brotherton Foundation | Easley | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $318k | 0 |
| MID-CAROLINA ELECTRIC TRUST INC ATTN THERESA CREPES | Lexington | T21Z Philanthropy, Voluntarism & Grantmaking Foundations | $318k | 0 |
| APPLEWHITE ADOPTIONS | Florence | P31 Human Services | $318k | 2 |
| SOUTH CAROLINA ALLIANCE OF BLACK SCHOOL EDUCATORS | Columbia | B03 Education | $318k | 2 |
| GREENWOOD AREA CHAMBER OF COMMERCE | Greenwood | — | $317k | 1 |
| HAITI GOSPEL FUND | Fountain Inn | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $317k | 0 |
| Aquatic Booster Club of the Southern Marlins Racing Team | Charleston | N67 Recreation & Sports | $317k | 0 |
| NATIONAL STEEPLECHASE MUSEUM INC | Camden | A50 Arts, Culture & Humanities | $317k | 0 |
| ST GEORGE AREA HOUSING CORPORATION | St George | — | $317k | 0 |
| Kappa Sigma Fraternity Chi Omega Ch | Columbia | — | $316k | 0 |
| INDIA ASSOCIATION OF GREENVILLEINC | Greenville | A23 Arts, Culture & Humanities | $315k | 0 |
| COUCHTON VOLUNTEER FIRE AND RESCUE | Aiken | M24 Public Safety, Disaster Preparedness & Relief | $315k | 0 |
| LOW COUNTRY VOLLEYBALL CLUB | Bluffton | N60 Recreation & Sports | $315k | 4 |
| BURTON CENTER FOUNDATION | Greenwood | — | $315k | 0 |
| AMERICAN POSTAL WORKERS UNION aka Columbia SC Area Local 807 | Columbia | — | $315k | 9 |
| GOOD SAMARITAN MEDICAL CLINIC INC | Chester | P20 Human Services | $315k | 0 |
| YOUTHBASE INC | Greenville | O50 Youth Development | $314k | 1 |
| NOTUS SPORTS | Greenville | N72 Recreation & Sports | $314k | 1 |
| SEA TURTLE PATROL HILTON HEAD ISLAND | Hilton Head | — | $314k | 2 |
| United Way of Greater Hartsville | Hartsville | — | $314k | 1 |
| MEALS ON WHEELS OF SUMMERVILLE INC | Summerville | K36Z Food, Agriculture & Nutrition | $314k | 0 |
| FOUNDATION FOR SPIRITUALITY AND THE ARTS INC | Charleston | A99 Arts, Culture & Humanities | $314k | 2 |
| THE SUSAN MORROW LEGACY FOUNDATION | Okatie | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $313k | 0 |
| MCCORMICK COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $313k | 1 |
| THE ANIMAL ADVOCATES | Barnwell | D11 Animal-Related | $313k | 0 |
| BACKPACK BUDDIES OF GREATER BLUFFTON AND HARDEEVILLE | Bluffton | J20 Employment | $313k | 0 |
| ORANGEBURG CALHOUN FREE MEDICAL CLINIC INC | Orangeburg | E32 Health Care | $313k | 0 |
| WINYAH RIVERS FOUNDATION INC | Conway | C30 Environment | $312k | 0 |
| GREENVILLE CIVIC CHORALE ASSOCIATION | Greenville | — | $312k | 1 |
| EDISTO HABITAT FOR HUMANITY INTERNATIONAL INC | Orangeburg | — | $312k | 0 |
