| Simba Educational Ministries | Garretson | B24 Education | $361k | 2 |
| DEUEL COUNTY MEMORIAL HOSPITAL | Clear Lake | — | $360k | 0 |
| WILD HORSES BUILDING CHAMPIONS INC | Eagle Butte | B99 Education | $359k | 1 |
| SIOUX FALLS TENNIS ASSOCIATION | Sioux Falls | N66Z Recreation & Sports | $358k | 1 |
| UNITED FAMILIES NONPROFIT CORPORATION | Rapid City | P40 Human Services | $355k | 2 |
| SCANDINAVIAN FARM MUTUAL INSURANCE | Langford | — | $355k | 0 |
| SOUTH DAKOTA OPTOMETRIC SOCIETY | Pierre | — | $355k | 1 |
| SOUTH DAKOTA TRUCKING ASSOCIATION | Sioux Falls | — | $354k | 0 |
| SHELDON F REESE FOUNDATION | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $353k | 1 |
| SOUTH DAKOTA BIOTECHNOLOGY ASSOCIATION | Sioux Falls | S41 Community Improvement & Capacity Building | $352k | 1 |
| NEW HAVEN | Sioux Falls | P46 Human Services | $352k | 2 |
| BADLANDS LITTLE BRITCHES RODEO FRANCHISE | Kadoka | O50 Youth Development | $352k | 0 |
| OLIVE GROVE GOLF COURSE INC | Groton | — | $351k | 0 |
| AMERICAN LEGION 229 GERTJE VANLITH | Big Stone City | — | $351k | 0 |
| First Baptist Church Foundation | Sioux Falls | X112 Religion-Related | $349k | 0 |
| SOUTH DAKOTA CPA SOCIETY | Sioux Falls | — | $349k | 1 |
| LAWRENCE COUNTY COALITION | Spearfish | S21 Community Improvement & Capacity Building | $348k | 0 |
| DIRECT LINE | Sioux Falls | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $348k | 0 |
| WE CARE RAPID CITY INC | Rapid City | P29 Human Services | $348k | 0 |
| FISH LAKE COUNTRY CLUB INC | Plankinton | — | $347k | 0 |
| CODINGTON COUNTY AMERICAN LEGION POST 17 | Watertown | — | $347k | 0 |
| SOUTH DAKOTA ASSOCIATION OF COOPERATIVES | Pierre | — | $346k | 1 |
| FORT RANDALL RECREATION INC | Pickstown | — | $345k | 0 |
| MILBANK AREA CHAMBER OF COMMERCE | Milbank | — | $345k | 1 |
| SOUTH DAKOTA CHAPTER INC - ACPA | Sioux Falls | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $345k | 0 |
| WICONI WAWOKIYA INC | Fort Thompson | — | $345k | 1 |
| Black Hills Juniors Volleyball Club | Rapid City | — | $345k | 3 |
| REGIONAL TECHNICAL EDUCATION CENTER INC | Yankton | B90 Education | $344k | 1 |
| Aberdeen Youth Soccer Association | Aberdeen | N64Z Recreation & Sports | $343k | 6 |
| PARKVIEW APARTMENTS INC | Arlington | — | $343k | 11 |
| MIDWEST EVANGELISTIC ASSOCIATION | Watertown | X20 Religion-Related | $342k | 0 |
| BEACON HILL RIFLE AND PISTOL CLUB | Volga | — | $341k | 0 |
| Faulkton Area Out of School Program | Faulkton | P33 Human Services | $341k | 1 |
| United States Bowling Congress 80475 South Dakota State USBC | Rapid City | — | $341k | 0 |
| HUMAN SERVICE AGENCY FOUNDATION | Watertown | — | $341k | 0 |
| JUSTICE THROUGH EMPOWERMENT NETWORK SOUTH DAKOTA FOUNDATION | Sioux Falls | P12 Human Services | $341k | 0 |
| PHILIP AMBULANCE SERVICE | Philip | E62 Health Care | $341k | 0 |
| BEADLE AND SPINK ENTERPRISE COMMUNITY INC | Doland | S320 Community Improvement & Capacity Building | $340k | 1 |
| WATERTOWN HOCKEY ASSOCIATION INC | Watertown | — | $340k | 0 |
| Western Hills Humane Society | Spearfish | — | $339k | 0 |
| FRATERNAL ORDER OF EAGLES | Vermillion | — | $339k | 0 |
| TWIN TOWNSHIP CEMETERY ASSOCIATION | Rosholt | Z99 Unknown | $338k | 0 |
| ASTORIA VOLUNTEER FIRE DEPARTMENT INC | Astoria | M24 Public Safety, Disaster Preparedness & Relief | $337k | 0 |
| NDN FUND INC | Rapid City | S12 Community Improvement & Capacity Building | $337k | 1 |
| Groundworks Connect | Sioux Falls | K19 Food, Agriculture & Nutrition | $337k | 0 |
| SOUTH DAKOTA MUNICIPAL LEAGUE GROUP RETURN | Ft Pierre | — | $337k | 0 |
| HAITI ALIVE INC | Tea | Q33 International, Foreign Affairs & National Security | $336k | 0 |
| DONALD STIP CHARITABLE REMAINDER | Sioux Falls | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $336k | 1 |
| FRATERNAL ORDER OF EAGLES RAPID CITY 3555 | Rapid City | Y82 Mutual & Membership Benefit | $335k | 2 |
| EYES UP SPORTS MINISTRIES | Sioux Falls | N11 Recreation & Sports | $333k | 4 |
