| TAMPA BAY WORKFORCE ALLIANCE INC | Tampa | W20 Public & Societal Benefit | $19.1M | 9 |
| SUNCOAST COMMUNITIES BLOOD BANK INC DBA SUNCOAST BLOOD CENTERS | Bradenton | E61Z Health Care | $19.1M | 3 |
| BRAVO FAMILY CHARITABLE FOUNDATION | Miami | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $19.1M | 0 |
| EVANGELICAL CHRISTIAN SCHOOL INC | Fort Myers | B24Z Education | $19M | 1 |
| BOYS & GIRLS CLUBS OF CENTRAL FLORIDA INC | Orlando | O230 Youth Development | $19M | 5 |
| SOUTH TECH CHARTER ACADEMY INC | Boynton Beach | B29 Education | $19M | 2 |
| FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION INC | Tallahassee | B110 Education | $19M | 10 |
| TIMUQUANA COUNTRY CLUB | Jacksonville | — | $18.9M | 7 |
| CENTER FOR FAMILY & CHILD ENRICHMENT INC | Miami Gardens | F30Z Mental Health & Crisis Intervention | $18.9M | 6 |
| FERD AND GLADYS ALPERT JEWISH FAMILY & CHILDREN'S SERVICE OF PBC & AFFILIATES | West Palm Beach | P20Z Human Services | $18.8M | 8 |
| SENIOR FRIENDSHIP CENTERS INC | Sarasota | — | $18.8M | 3 |
| ELMLAND COMMUNITY FOUNDATION INC | Delray Beach | L21 Housing & Shelter | $18.7M | 0 |
| Free & Accepted Masons of Florida Most Worshipful Grand Lodge | Jacksonville | Y40Z Mutual & Membership Benefit | $18.7M | 2 |
| RAY FOUNDATION INC | Naples | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.7M | 3 |
| THEODORE R AND VIVIAN M JOHNSON SCHOLARSHIP FOUNDATION INC | West Palm Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.7M | 10 |
| VIERA CHARTER SCHOOLS INC | Viera | B20 Education | $18.7M | 1 |
| AIR FORCE ENLISTED VILLAGE INC | Shalimar | L50 Housing & Shelter | $18.7M | 3 |
| BIG DOG RANCH RESCUE INC | Loxahatchee Groves | D20 Animal-Related | $18.6M | 0 |
| FLORIDA STUDIO THEATRE INC | Sarasota | A650 Arts, Culture & Humanities | $18.5M | 5 |
| THE STILES-NICHOLSON FOUNDATION | Jupiter | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.5M | 0 |
| EARLY LEARNING COALITION OF FLORIDA'S GATEWAY INC | Lake City | B012 Education | $18.5M | 2 |
| INTERNATIONAL STUDIES CHARTER HIGH SCHOOL INC | Miami | B29 Education | $18.5M | 2 |
| Orangewood Christian School Inc | Maitland | B20 Education | $18.5M | 5 |
| PAUL AND LYNN LEIGHT CHARITABLE FOUNDATION INC | Fort Lauderdale | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.4M | 0 |
| WESTMINSTER SERVICES INC | Orlando | L02 Housing & Shelter | $18.4M | 9 |
| FLORIDA ACHIEVEMENT SUPPORT TRUST | Coral Gables | O99 Youth Development | $18.4M | 1 |
| The Arc of the St Johns Inc | Saint Augustine | P820 Human Services | $18.4M | 3 |
| ST PETERSBURG COLLEGE FOUNDATION INC | Saint Petersburg | B110 Education | $18.4M | 5 |
| THE GALILEO SCHOOL FOUNDATION INC | Sanford | B99 Education | $18.3M | 2 |
| UFCW & EMPLOYERS KANSAS & MISSOURI HEALTH AND WELFARE TRUST FUND | Pembroke Pines | — | $18.3M | 2 |
| J CHRISTOPHER AND ANNE N REYES FOUNDATION | West Palm Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.2M | 0 |
| PORT OF MIAMI CRANE MANAGEMENT INC | Miami | W99 Public & Societal Benefit | $18.2M | 6 |
| CRYSTAL LAKE SUPPORTIVE ENVIRONMENTS INC | Orlando | E50Z Health Care | $18.2M | 3 |
| THE TWINEAGLES CLUB INC | Naples | N6A Recreation & Sports | $18.2M | 8 |
| DOWNTOWN DORAL CHARTER UPPER SCHOOL INC | Doral | B29 Education | $18.2M | 1 |
| Harvey & Phyllis Sandler Foundation Inc | Boca Raton | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.2M | 0 |
| PACE WATER SYSTEM INC | Pace | — | $18.1M | 2 |
| RIDGEVIEW GLOBAL STUDIES ACADEMY INC | Davenport | B29 Education | $18.1M | 0 |
| BIG CAT RESCUE CORP | Odessa | P30 Human Services | $18.1M | 3 |
| Jessie Ball duPont Religious Charitable & Educational Fund | Jacksonville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.1M | 9 |
| EASTER SEALS SOUTH FLORIDA INC | Miami | E50Z Health Care | $18M | 5 |
| Miami Rescue Mission Inc | Miami | L410 Housing & Shelter | $18M | 5 |
| JACOB ZABARA FAMILY FOUNDATION | Miami Beach | G12 Diseases, Disorders & Medical Disciplines | $17.9M | 1 |
| THE FIRST NATION GROUP FOUNDATION INC | Niceville | W30 Public & Societal Benefit | $17.9M | 0 |
| ADMIRAL FARRAGUT ACADEMY INC | St Petersburg | B250 Education | $17.9M | 6 |
| FRIENDS OF BOCA GRANDE COMMUNITY CENTER INC | Boca Grande | P28Z Human Services | $17.9M | 1 |
| TWELVE STARS FOUNDATION | Palm Beach | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $17.9M | 0 |
| North Florida Medical Centers Inc | Tallahassee | E30C Health Care | $17.9M | 8 |
| SCAIFE FAMILY FOUNDATION | West Palm Beach | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $17.8M | 5 |
| COPPERHEAD CHARITIES INC | Palm Harbor | T990 Philanthropy, Voluntarism & Grantmaking Foundations | $17.8M | 4 |
