| BERKELEY SENIORS INC | Moncks Corner | P81 Human Services | $977k | 0 |
| CHARLES LEA INDUSTRIAL CORPORATION | Spartanburg | — | $977k | 0 |
| THE WAREHOUSE THEATRE | Greenville | A650 Arts, Culture & Humanities | $974k | 2 |
| LAST CHANCE ANIMAL RESCUE FUND INC | Carlisle | D20 Animal-Related | $973k | 2 |
| THE ORIGINAL SIX FOUNDATION | Columbia | S20 Community Improvement & Capacity Building | $971k | 2 |
| WAKE UP CAROLINA | Mount Pleasant | F20 Mental Health & Crisis Intervention | $970k | 3 |
| THE FIDUCIARY AND INVESTMENT RISK MANAGEMENT ASSOCIATION INC | Lancaster | S41 Community Improvement & Capacity Building | $969k | 1 |
| THE BRIDGE CENTER RECOVERY | Anderson | P80 Human Services | $968k | 1 |
| GOUCHER WATER COMPANY INC | Pacolet | — | $966k | 0 |
| MID COUNTY WATER COMPANY INC | Winnsboro | — | $965k | 0 |
| Help Up Works Inc | Spartanburg | B99 Education | $961k | 0 |
| MISS SOUTH CAROLINA SCHOLARSHIP ORGANIZATION INC | Hartsville | B82 Education | $958k | 0 |
| SOUTHEAST CHAPTER OF THE AMERICAN ASSOCIATION OF AIRPORT EXECUTIVES | North Charleston | — | $957k | 1 |
| BMW CAR CLUB OF AMERICA FOUNDATION | Greer | B99 Education | $954k | 0 |
| HUMANE SOCIETY OF NORTH MYRTLE BEACH INC | North Myrtle Beach | D20 Animal-Related | $953k | 0 |
| THE COURAGE CENTER | Lexington | F20 Mental Health & Crisis Intervention | $951k | 2 |
| TREES GREENVILLE | Greenville | C50 Environment | $950k | 1 |
| THE CHESTER FOUNDATION | Chester | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $949k | 6 |
| SOUTH LYNCHES FIRE DEPARTMENT INC | Lake City | M24 Public Safety, Disaster Preparedness & Relief | $948k | 0 |
| SOUTH CAROLINA ALLIANCE OF HEALTH PLANS | Columbia | — | $944k | 0 |
| CAROLINA ONE VOLLEYBALL | Simpsonville | N60 Recreation & Sports | $943k | 5 |
| LEE AND SUMTER COUNTY ALLIANCE THELINK | Sumter | S30 Community Improvement & Capacity Building | $942k | 0 |
| BERKELEY COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $941k | 1 |
| SICKLE FORWARD | Greenville | E01 Health Care | $941k | 0 |
| PS I LOVE YOU MINISTRIES | Spartanburg | P30 Human Services | $940k | 1 |
| HELP 4 KIDS | Myrtle Beach | P20 Human Services | $938k | 0 |
| Center for Independent Employees | Spartanburg | J99 Employment | $935k | 5 |
| Aiken County Habitat for Humanity Inc | Aiken | — | $935k | 1 |
| FOSTERING GREAT IDEAS | Greenville | P32 Human Services | $934k | 1 |
| THE BIRK FAMILY FOUNDATION INC | Mt Pleasant | T20J Philanthropy, Voluntarism & Grantmaking Foundations | $933k | 0 |
| LINCOLN HIGH SCHOOL PRESERVATION AL | Sumter | B84 Education | $932k | 0 |
| BULLS SOCCER CLUB INC | Aiken | N60 Recreation & Sports | $930k | 0 |
| SEA PINES MONTESSORI ACADEMY | Hilton Head Island | — | $927k | 1 |
| AMERICAN SOCIETY OF PHLEBOTOMY TECH | Summerville | — | $926k | 0 |
| CKC VOLUNTEER FIRE DEPARTMENT | Blacksburg | — | $925k | 0 |
| BEYOND ABUSE | Greenwood | — | $925k | 1 |
| USCColumbia Technology Incubator | Columbia | S20 Community Improvement & Capacity Building | $922k | 0 |
| SOUTH CAROLINA YOUTH SHOOTING FOUNDATION | Rock Hill | O50 Youth Development | $921k | 5 |
| TOGETHER SC | Columbia | S80 Community Improvement & Capacity Building | $921k | 2 |
| REACH ACROSS | Leesville | — | $920k | 1 |
| WOMENS RIGHTS AND EMPOWERMENT NETWORK | Columbia | P01 Human Services | $919k | 5 |
| DISCOVER UPCOUNTRY CAROLINA ASSOCIATION | Greenville | S41 Community Improvement & Capacity Building | $919k | 1 |
| DARLINGTON COUNTY COUNCIL ON AGING | Darlington | P81Z Human Services | $918k | 1 |
| CROSS CONNECTING NETWORK | Mount Pleasant | X20 Religion-Related | $918k | 2 |
| NEHEMIAH COMMUNITY REVITALIZATION CORPORATION | Greer | — | $917k | 1 |
| Fairfield County School District Education Foundation | Winnsboro | L20 Housing & Shelter | $917k | 0 |
| Palmetto Womens Center | Rock Hill | E400 Health Care | $916k | 1 |
| VALEO INC | Columbia | X99 Religion-Related | $915k | 2 |
| PALMETTO STRIKERS VOLLEYBALL CLUB LLC | Mount Pleasant | O50 Youth Development | $914k | 2 |
| PROVIDENCE HOME | Columbia | — | $914k | 1 |
