| SC UPLIFT COMMUNITY OUTREACH | Columbia | S21 Community Improvement & Capacity Building | $881k | 1 |
| FOSTER CHILDCARE & DEELOPMENT | North Charleston | P30 Human Services | $881k | 1 |
| Faith Wins | Prosperity | X02 Religion-Related | $879k | 0 |
| SOUTH CAROLINA RURAL REHABILITATION | Gilbert | — | $878k | 7 |
| NATIONAL STATES GEOGRAPHIC | Myrtle Beach | — | $877k | 0 |
| DON RYAN CENTER FOR INNOVATION INC | Bluffton | S31 Community Improvement & Capacity Building | $876k | 1 |
| YORK COUNTY DISABILITIES FOUNDATION | York | E116 Health Care | $876k | 1 |
| Maritime Cybersecurity Institute | Beaufort | B90 Education | $875k | 0 |
| CENTRE STAGE-SOUTH CAROLINA INC | Greenville | A62 Arts, Culture & Humanities | $874k | 1 |
| COLLEGE OF CHARLESTON ALUMNI ASSOCIATION | Charleston | B84Z Education | $869k | 2 |
| HELPING HANDS MINISTRIES OF THE | Woodruff | P60Z Human Services | $869k | 2 |
| COLUMBIA STAGE SOCIETY | Columbia | A650 Arts, Culture & Humanities | $869k | 0 |
| MAN 2 MAN FATHERHOOD INITIATIVE OF | Bennettsville | A23 Arts, Culture & Humanities | $868k | 0 |
| ORANGEBURG COUNTY COUNCIL ON AGING | Orangeburg | P81Z Human Services | $867k | 2 |
| THE PALMETTO SCHOOL | Rock Hill | B29 Education | $864k | 1 |
| MCBRIDE FAMILY FOUNDATION | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $860k | 0 |
| TROY-JOHNSON LEARNING KORNER INC | Mullins | P33Z Human Services | $858k | 1 |
| MUNGO HOMES FOUNDATION INC | Irmo | P20 Human Services | $858k | 0 |
| Advanced Institute for Development and Learning | Greenville | G84 Diseases, Disorders & Medical Disciplines | $858k | 0 |
| COLUMBIA POST OFFICE CREDIT UNION | Columbia | — | $855k | 0 |
| HARVEST CHRISTIAN MINISTRIES INC | Abbeville | P99 Human Services | $851k | 0 |
| GREATER SUMMERVILLEDORCHESTER COUN | Summerville | — | $850k | 0 |
| PUBLIC EDUCATION PARTNERS | Greenville | B20A Education | $849k | 1 |
| DREAMS IMAGINATION & GIFT DEVELOPMENT PROGRAM DIG | Simpsonville | O50 Youth Development | $847k | 1 |
| South Carolina Pharmaceutical | Columbia | S41 Community Improvement & Capacity Building | $845k | 1 |
| SOUTH CAROLINA STATE FIREFIGHTERS' | Columbia | B82 Education | $844k | 0 |
| APPALACHIAN DEVELOPMENT CORPORATION | Greenville | — | $843k | 1 |
| THE HAWKINS FOUNDATION | Greenville | H50 Medical Research | $843k | 0 |
| The American Legion Dept of SC | Columbia | — | $840k | 2 |
| Palmetto Citizens Against Sexual Assault | Lancaster | — | $839k | 1 |
| FRESH FUTURE FARM INC | Charleston | K99 Food, Agriculture & Nutrition | $839k | 1 |
| CROSS OUTREACH MINISTRIES INC | Bluffton | X192 Religion-Related | $839k | 0 |
| Blue Ribbon Schools of Excellence | Chapin | B129 Education | $839k | 1 |
| SOUTH CAROLINA POLICY COUNCIL | Columbia | — | $838k | 0 |
| Coker University Foundation | Hartsville | — | $837k | 0 |
| ABUNDANCE CAPITAL | Greenville | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $837k | 2 |
| Support After Abortion Inc | Simpsonville | S20 Community Improvement & Capacity Building | $836k | 1 |
| York County Regional Chamber of Commerce | Rock Hill | — | $836k | 2 |
| MACEDONIA FIRE DISTRICT | Gaffney | M24 Public Safety, Disaster Preparedness & Relief | $835k | 0 |
| INTERNATIONAL TOWN AND GOWN ASSN | Clemson | B05 Education | $835k | 0 |
| SOUTH CAROLINA NATIONAL HERITAGE | Belton | A80 Arts, Culture & Humanities | $835k | 1 |
| UNITED WAY OF LAURENS COUNTY INC | Clinton | — | $834k | 1 |
| STAR GOSPEL MISSION | Mount Pleasant | — | $833k | 1 |
| THE GOODCOIN GIVING FUND | Charleston | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $832k | 0 |
| Carols Hope for Childhood Cancer Inc | Spartanburg | P20 Human Services | $832k | 0 |
| UWS PROPERTIES INC | Greenville | S47 Community Improvement & Capacity Building | $832k | 0 |
| OUR UPSTATE SC | Greenville | S99 Community Improvement & Capacity Building | $831k | 1 |
| FIRE PIT RANCH | Moore | O50 Youth Development | $831k | 2 |
| LOWCOUNTRY BIBLICAL COUNSELING CENTER | Charleston | F60 Mental Health & Crisis Intervention | $829k | 0 |
| GVW VOLUNTEER FIRE DEPARTMENT IN | Graniteville | M24 Public Safety, Disaster Preparedness & Relief | $829k | 0 |
