| BIG BROTHERS BIG SISTERS OF THE | North Charleston | O31 Youth Development | $828k | 1 |
| VETERANS WELCOME HOME AND RESOURCE | Little River | W30 Public & Societal Benefit | $827k | 1 |
| BEAUFORT COUNTY ECONOMIC DEVELOPMENT | Hilton Head Island | S30 Community Improvement & Capacity Building | $827k | 1 |
| SHRINERS INTERNATIONAL | Mount Pleasant | — | $826k | 0 |
| INTERFAITH COMMUNITY SERVICES OF SC | Columbia | P33Z Human Services | $825k | 0 |
| GREATER FLORENCE CHAMBER OF COMMERCE | Florence | — | $824k | 1 |
| SCAGO Educational Facilities Corporation for Sumter County School District | Sumter | B11 Education | $823k | 0 |
| CAROLINA PREGNANCY CENTER | Spartanburg | E400 Health Care | $822k | 1 |
| WACCAMAW YOUTH CENTER INC | Conway | — | $821k | 1 |
| BMW CAR CLUB OF AMERICA FOUNDATION | Greer | B99 Education | $820k | 0 |
| FRIENDS OF THE AIKEN CO PUBLIC LIBRARY | Aiken | — | $820k | 0 |
| TCM ENTERPRISES LLC | Greenville | — | $820k | 0 |
| Aiken County Habitat for Humanity Inc | Aiken | — | $819k | 1 |
| GREENWOOD PATHWAY HOUSE FOUNDATION | Greenwood | T40 Philanthropy, Voluntarism & Grantmaking Foundations | $817k | 0 |
| SOUTHEAST AFFORDABLE HOUSING | Greenville | L21 Housing & Shelter | $816k | 1 |
| CHARLESTON YACHT CLUB | Charleston | — | $813k | 0 |
| Neighbors Together Inc | North Charleston | P20Z Human Services | $811k | 1 |
| Charleston Legal Access | North Charleston | I80 Crime & Legal-Related | $809k | 1 |
| Gullah Traveling Theater Inc | Beaufort | A65 Arts, Culture & Humanities | $808k | 2 |
| The Village Group | Georgetown | O20 Youth Development | $808k | 0 |
| DEWEES UTILITY CORPORATION | Dewees Island | Y22 Mutual & Membership Benefit | $805k | 0 |
| RAGIN PREPARATORY CHRISTIAN ACADEMY | Sumter | B21 Education | $805k | 0 |
| KENNEDYS S ASSISTIVE LIVING & EDUCATION | Columbia | P82 Human Services | $803k | 1 |
| KERSHAW AREA RESOURCE EXCHANGE | Kershaw | P60Z Human Services | $803k | 0 |
| ANY LENGTHS RECOVERY INC | Sumter | F20 Mental Health & Crisis Intervention | $802k | 0 |
| LITTLEJOHN COMMUNITY CENTER INC | Clemson | S24Z Community Improvement & Capacity Building | $802k | 1 |
| THE H NEEL HIPP AND SCOTT TIMMONS | Greenville | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $802k | 0 |
| IRONWORKERS JOINT APPRENTICESHIP | Charleston | — | $800k | 0 |
| SUMTER SPCA & HUMANE EDUCATION | Sumter | D200 Animal-Related | $800k | 4 |
| SIGNS 4 JESUS | Rock Hill | X20 Religion-Related | $800k | 0 |
| GREEN HEART PROJECT INC | Charleston | C42 Environment | $800k | 1 |
| TREES GREENVILLE | Greenville | C50 Environment | $799k | 2 |
| Middle East Ministries | Fairforest | Q330 International, Foreign Affairs & National Security | $799k | 2 |
| LORD BERKELEY CONSERVATION TRUST | Moncks Corner | — | $798k | 1 |
| BLACK PAGES INTERNATIONAL INC | Columbia | S31 Community Improvement & Capacity Building | $796k | 2 |
| MOUNTAIN VIEW CHRISTIAN ACADEMY | Cowpens | B20 Education | $796k | 0 |
| NOAH'S ARKS RESCUE | Okatie | D20 Animal-Related | $795k | 0 |
| GROUND ZERO MINISTRIES INC | Myrtle Beach | O55 Youth Development | $795k | 1 |
| ACX BOOSTER CLUB OF CHARLESTON | Ladson | B11 Education | $794k | 0 |
| THE HIVE COMMUNITY CIRCLE | Columbia | P80 Human Services | $793k | 5 |
| UNCOMMON CHARITABLE IMPACT INC | Charleston | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $792k | 1 |
| CORE ACADEMY | Hopkins | K12 Food, Agriculture & Nutrition | $792k | 0 |
| LIONS VISION SERVICES | Columbia | G41 Diseases, Disorders & Medical Disciplines | $792k | 1 |
| JAMES ISLAND OUTREACH | Charleston | L81Z Housing & Shelter | $790k | 1 |
| COLUMBIA JEWISH FEDERATION | Columbia | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $789k | 0 |
| ANDERSON COUNTY CONVENTION & VISITORS BUREAU | Anderson | S41 Community Improvement & Capacity Building | $788k | 1 |
| HILINSKI'S HOPE INC | Irmo | F99 Mental Health & Crisis Intervention | $788k | 0 |
| AMERICAN SHORE & BEACH | Beaufort | C300 Environment | $787k | 0 |
| GREATER THAN US INC | Lyman | S12 Community Improvement & Capacity Building | $787k | 0 |
| HALLIE HILL ANIMAL SANCTUARY | Hollywood | D20 Animal-Related | $786k | 0 |
