| IBU Foundation | Charleston | Q12 International, Foreign Affairs & National Security | $913k | 1 |
| PSL FOUNDATION | Columbia | W05 Public & Societal Benefit | $913k | 0 |
| HEALTHY SMILES OF SPARTANBURG INC | Spartanburg | E32 Health Care | $912k | 0 |
| FOSTER CHILDCARE & DEELOPMENT | North Charleston | P30 Human Services | $908k | 1 |
| GRAND LODGE OF ANCIENT FREE MASONS OF SC INC | Lexington | — | $908k | 2 |
| MIRACLE ACADEMY NURSERY CENTER INC | Russellville | B20 Education | $904k | 0 |
| ORANGEBURG CHRISTIAN ACADEMY INC | Orangeburg | B20 Education | $902k | 0 |
| AIKEN TECHNICAL COLLEGE FOUNDATION | Aiken | — | $902k | 1 |
| CAROLINA INTERNATIONAL PREP SCHOOL | Greenville | B24 Education | $901k | 1 |
| HELPING HANDS MINISTRIES OF THE WOODRUFF AREA INC | Woodruff | P60Z Human Services | $901k | 2 |
| JAMES ISLAND OUTREACH | Charleston | L81Z Housing & Shelter | $901k | 1 |
| WORLD PARROT TRUST USA INC | Travelers Rest | D30Z Animal-Related | $900k | 2 |
| Evangelical Institute of Greenville | Greenville | — | $899k | 0 |
| HERITAGE CHRISTIAN ACADEMY | Lexington | B99 Education | $899k | 0 |
| Timmonsville Rescue Squad | Timmonsville | M20Z Public Safety, Disaster Preparedness & Relief | $898k | 3 |
| THE HAWKINS FOUNDATION | Greenville | H50 Medical Research | $898k | 0 |
| SPARTANBURG AREA CONSERVANCY INC | Spartanburg | — | $898k | 1 |
| COLLINS HOME FAMILY MINISTRIES | Seneca | — | $897k | 1 |
| JAMES R CLARK MEMORIAL SICKLE CELL FOUNDATION INC | Columbia | G22Z Diseases, Disorders & Medical Disciplines | $896k | 1 |
| CHILD DEVELOPMENT CENTER RBC | Columbia | O50 Youth Development | $894k | 0 |
| CENTER FOR COURAGE & RENEWAL | Greenville | B60 Education | $893k | 2 |
| SEEDS OF LIFE INC | Mount Pleasant | F30 Mental Health & Crisis Intervention | $893k | 0 |
| JOHN T STEVENS FOUNDATION | Kershaw | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $892k | 4 |
| SOUTH CAROLINA BEER WHOLESALERS ASSN | Columbia | — | $890k | 0 |
| THE BARGAIN BOX | Hilton Head Island | — | $888k | 0 |
| LAURENS MEMORIAL HOME FOR THE AGED INC | Laurens | P75Z Human Services | $884k | 0 |
| YAGER FREEDOM FOUNDATION | Fort Mill | X20 Religion-Related | $881k | 0 |
| SC UPLIFT COMMUNITY OUTREACH | Columbia | S21 Community Improvement & Capacity Building | $881k | 1 |
| NANCY K PERRY CHILDRENS SHELTER | Lexington | — | $879k | 1 |
| SOUTH CAROLINA JUNIOR GOLF ASSOCIATION | Irmo | — | $876k | 1 |
| GOOD NEIGHBOR FREE MEDICAL CLINIC OF BEAUFORT | Beaufort | E322 Health Care | $876k | 3 |
| YORK COUNTY DISABILITIES FOUNDATION | York | E116 Health Care | $876k | 1 |
| SHEET METAL AIR RAIL & TRANSPORTATION WORKERS LOCAL #399 | Charleston | J40 Employment | $875k | 9 |
| THE CHARLES W & ELIZABETH H COKER FOUNDATION | Hartsville | — | $875k | 0 |
| Maritime Cybersecurity Institute | Beaufort | B90 Education | $875k | 0 |
| CENTRE STAGE-SOUTH CAROLINA INC | Greenville | A62 Arts, Culture & Humanities | $874k | 1 |
| GREATER FLORENCE HABITAT FOR HUMANITY | Florence | — | $873k | 2 |
| BEAUFORT COUNTY BLACK CHAMBER OF | Beaufort | S20 Community Improvement & Capacity Building | $873k | 1 |
| BRAVO ZULU RETREAT INC | Columbia | W30 Public & Societal Benefit | $872k | 0 |
| COLLEGE OF CHARLESTON ALUMNI ASSOCIATION | Charleston | B84Z Education | $869k | 2 |
| COLUMBIA STAGE SOCIETY | Columbia | A650 Arts, Culture & Humanities | $869k | 0 |
| MAN 2 MAN FATHERHOOD INITIATIVE OF | Bennettsville | A23 Arts, Culture & Humanities | $868k | 0 |
| INTERNATIONAL TOWN AND GOWN ASSN | Clemson | B05 Education | $867k | 0 |
| ORANGEBURG COUNTY COUNCIL ON AGING | Orangeburg | P81Z Human Services | $867k | 2 |
| NATIONAL STATES GEOGRAPHIC INFORMATION COUNCIL | Myrtle Beach | — | $866k | 1 |
| DISCIPLES VILLAGE | Lexington | Q33 International, Foreign Affairs & National Security | $864k | 3 |
| COMPASS OF CAROLINA INC | Greenville | B99Z Education | $859k | 2 |
| MUNGO HOMES FOUNDATION INC | Irmo | P20 Human Services | $858k | 0 |
| Advanced Institute for Development and Learning | Greenville | G84 Diseases, Disorders & Medical Disciplines | $858k | 0 |
| INTERFAITH COMMUNITY SERVICES OF SC | Columbia | P33Z Human Services | $857k | 0 |
