| Palmetto Citizens Against Sexual Assault | Lancaster | — | $673k | 1 |
| YWAM MYRTLE BEACH INC | Myrtle Beach | X99 Religion-Related | $672k | 0 |
| THE RESERVE AT LAKE KEOWEE CHARITABLE FOUNDATION | Sunset | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $672k | 0 |
| SCSDB FOUNDATION | Spartanburg | — | $671k | 1 |
| LUTHERAN SERVANTS FOR CHRIST | Goose Creek | X20 Religion-Related | $669k | 0 |
| SUPPORTERS OF SCHOOL DISTRICT NO 1 INC | Campobello | B112 Education | $669k | 0 |
| MCBRIDE FAMILY FOUNDATION | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $667k | 0 |
| FOSTERING FOSTER ANIMAL RESCUE | Camden | D20 Animal-Related | $666k | 0 |
| COASTLINE WOMENS CENTER | Conway | P40 Human Services | $665k | 2 |
| SOUTH CAROLINA OPTOMETRIC PHYSICIANS ASSOCIATION | Columbia | — | $665k | 1 |
| TRUSTUS INC | Columbia | A65Z Arts, Culture & Humanities | $665k | 0 |
| BEAUFORT REGIONAL CHAMBER OF COMMERCE | Beaufort | — | $665k | 0 |
| BOYKIN SPANIEL RESCUE INC | Boiling Springs | D20 Animal-Related | $665k | 4 |
| WILDERNESS WAY CAMP SCHOOL INC | Fair Play | P30Z Human Services | $664k | 2 |
| Trinity Educational Community Center | Columbia | P28 Human Services | $664k | 2 |
| CERAMIC TILE EDUCATION FOUNDATION INC | Anderson | J22 Employment | $662k | 2 |
| USS YORKTOWN FOUNDATION | Mt Pleasant | A54 Arts, Culture & Humanities | $661k | 0 |
| MT PISGAH APARTMENTS INC | West Columbia | — | $661k | 0 |
| MEDICINAL WHISKEY CHARITY INC | Greenville | E12 Health Care | $660k | 0 |
| Rho Chapter Kappa Alpha Housing Corp | Columbia | S47 Community Improvement & Capacity Building | $657k | 0 |
| FLORENCE-DARLINGTON TECHNICAL COLLEGE EDUCATIONAL FOUNDATION | Florence | B42I Education | $655k | 0 |
| AIKEN LAND CONSERVANCY INC | Aiken | C340 Environment | $655k | 4 |
| CAROMI RURAL VOL FIRE DEPARTME | Ladson | M24Z Public Safety, Disaster Preparedness & Relief | $655k | 0 |
| SOVEREIGN MILITARY ORDER OFTHE TEMPLE OF JERUSALEM | Murrells Inlet | — | $654k | 0 |
| PRECIOUS ONE LEARNING CENTER INC | Florence | — | $654k | 0 |
| CHEROKEE COUNTY CHAMBER OF COMMERCE | Gaffney | — | $653k | 1 |
| THE ROBERTS FOUNDATION FOUNDED BY WILLIAM C ROBERTS MD | Charleston | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $653k | 2 |
| THE REGENSIS INSTITUTE | Spartanburg | S31 Community Improvement & Capacity Building | $652k | 2 |
| MT ZION AME APARTMENTS INC SEC 1 | West Columbia | L22 Housing & Shelter | $652k | 0 |
| Rock Hill Economic Development Corporation | Rock Hill | S310 Community Improvement & Capacity Building | $651k | 0 |
| GREENVILLE LOCAL DEVELOPMENT CORPORATION | Greenville | — | $651k | 0 |
| SIX OAKS CEMETERY INC | Hilton Head | Y50 Mutual & Membership Benefit | $650k | 2 |
| THE DELANEY FAMILY FOUNDATION | Kiawah Island | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $650k | 0 |
| CHIEFS ATHLETIC BOOSTER CLUB | Little River | B11 Education | $650k | 0 |
| INCREASING HOPE | North Charleston | P51 Human Services | $649k | 1 |
| GRAND STRAND BUSINESS ALLIANCE | Myrtle Beach | S41 Community Improvement & Capacity Building | $649k | 0 |
| PIMLICO RURAL VOLUNTEER FIRE DEPARTMENT | Moncks Corner | M24 Public Safety, Disaster Preparedness & Relief | $648k | 0 |
| Friendship Place Inc | Georgetown | L410 Housing & Shelter | $646k | 1 |
| NATIONAL ASSOCIATION FOR CONTINENCE | Charleston | — | $646k | 1 |
| Carolina Childrens Home | Columbia | P70 Human Services | $645k | 1 |
| PROSPERITY CHILDCARE INC | Lamar | P33 Human Services | $643k | 2 |
| PARTRIDGE CREEK GUN CLUB INC | Ridgeville | N61 Recreation & Sports | $643k | 0 |
| ANGELS CLUB | Columbia | B80 Education | $642k | 0 |
| SMART FAMILY FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $641k | 0 |
| LEXINGTON COUNTY SOCCER CLUB | Lexington | N64 Recreation & Sports | $641k | 0 |
| SHRINERS INTERNATIONAL OMAR SHRINERS GROUP RETURN | Mount Pleasant | — | $639k | 0 |
| A FATHERS WAY | Lancaster | P400 Human Services | $638k | 1 |
| WILD HEARTS EQUINE THERAPY CENTER | Seneca | E50 Health Care | $638k | 0 |
| MEGIDDO DREAM STATION | Graniteville | P20 Human Services | $638k | 1 |
| Contoocook Housing Trust | Lyman | — | $637k | 1 |
