| LOWCOUNTRY CHRISTIAN COMMUNITY SCHOOL | Daniel Island | B200 Education | $603k | 0 |
| AIKEN CENTER FOR THE ARTS INC | Aiken | A400 Arts, Culture & Humanities | $602k | 1 |
| SOUTH CAROLINA FREE CLINIC ASSOC | Union | E60 Health Care | $601k | 0 |
| HEALTHY SMILES OF SPARTANBURG INC | Spartanburg | E32 Health Care | $601k | 0 |
| Institute for Strategic and Equitable Development | Charleston | S30 Community Improvement & Capacity Building | $600k | 1 |
| Life Unplugged | Hardeeville | O50 Youth Development | $600k | 2 |
| Jewish Family Services of | Charleston | P50 Human Services | $599k | 1 |
| DELTA CHAPTER ALUMNI HOUSE CORPORATION | Columbia | B83 Education | $599k | 0 |
| COLLEGE PANHELLENIC ASSOCIATION | Columbia | N50 Recreation & Sports | $599k | 0 |
| LOCAL BOYS DO GOOD | Greenville | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $597k | 0 |
| Alliance for a Healthier South Carolina | Columbia | — | $596k | 3 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B012 Education | $595k | 1 |
| NATIONAL GUARD ASSOCIATION OF SC | Columbia | W30 Public & Societal Benefit | $594k | 0 |
| PLEASANT VALLEY CONNECTION | Greenville | P28 Human Services | $593k | 1 |
| JASPER ANIMAL RESCUE MISSION | Ridgeland | D20 Animal-Related | $593k | 1 |
| NATHANS FRIENDS | Johns Island | P20 Human Services | $593k | 0 |
| 836 INC | Myrtle Beach | P80 Human Services | $591k | 0 |
| SOUTH CAROLINA HEALTH | Columbia | — | $591k | 0 |
| I58 INC | Chester | L40 Housing & Shelter | $590k | 1 |
| FIX HORRY ROADS | Myrtle Beach | W01 Public & Societal Benefit | $589k | 0 |
| BELVEDERE EARLY LEARNING CENTER INC | Columbia | — | $588k | 1 |
| BAPTIST EDUCATIONAL AND MISSIONARY | Columbia | — | $588k | 0 |
| Columbia City Jazz Company | Columbia | A680 Arts, Culture & Humanities | $588k | 4 |
| MATTHEW2540 | Greenwood | X20 Religion-Related | $588k | 0 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B012 Education | $587k | 0 |
| NATIONAL SOCIETY OF THE COLONIAL | Charleston | A800 Arts, Culture & Humanities | $586k | 0 |
| EDGEFIELD COUNTY YOUTH EMPOWERMENT CENTER | Johnson | O50 Youth Development | $586k | 0 |
| Clinical Biotechnology Research Institute at RSFH | Charleston | H99 Medical Research | $585k | 18 |
| CONFEDERATE HOME AND COLLEGE | Charleston | L410 Housing & Shelter | $583k | 0 |
| AMAZING GRACE PARK CLEMENTA | Marion | N32 Recreation & Sports | $582k | 0 |
| Charleston Apartment Association | Charleston | — | $582k | 0 |
| TRIDENT LITERACY ASSOCIATION INC | N Charleston | — | $582k | 0 |
| CONGAREE VISTA GUILD | Columbia | S41 Community Improvement & Capacity Building | $581k | 1 |
| LANCASTER COUNTY SOCIETY FOR HISTORICAL PRESERVATION INC | Lancaster | — | $581k | 0 |
| FORT MILL UNITED INC | Fort Mill | N64 Recreation & Sports | $581k | 2 |
| UNION COUNTY COUNCIL ON AGING | Union | P81Z Human Services | $581k | 0 |
| PHIFERJOHNSON FOUNDATION | Spartanburg | — | $580k | 0 |
| FAMILY PROMISE OF BEAUFORT COUNTY | Bluffton | P20 Human Services | $579k | 1 |
| BRICE-SANDERS FOUNDATION | Greenville | X20 Religion-Related | $579k | 1 |
| KAPPA ALPHA ORDER | Columbia | — | $577k | 0 |
| HATCHER GARDEN AND WOODLAND PRESERVE IN | Spartanburg | C36 Environment | $577k | 0 |
| SOUTH CAROLINA COUNCIL ON ECONOMIC | Columbia | — | $576k | 2 |
| WORLD YOUTH GROUP | Westminster | X20 Religion-Related | $576k | 0 |
| ANDERSON COUNTY HUMANE SOCIETY | Anderson | D200 Animal-Related | $576k | 0 |
| LET THERE BE MOM INC | Greenville | P40 Human Services | $576k | 1 |
| INDEPENDENT BANKS OF SOUTH CAROLINA | Chapin | — | $575k | 0 |
| DICK HORNE FOUNDATION | Orangeburg | — | $575k | 3 |
| SPANISH WELLS POA | Hilton Head Island | — | $573k | 0 |
| LANGSTON FOUNDATION INC | Greenville | B21 Education | $573k | 0 |
| Spartanburg Area Housing Corporation | Spartanburg | L20 Housing & Shelter | $572k | 0 |
