| MECHANICAL CONTRACTORS ASSOCIATION OF SOUTH CAROLINA | Columbia | — | $637k | 1 |
| NATIONAL AFRICAN AMERICAN RVers | Columbia | N50 Recreation & Sports | $636k | 0 |
| LILY PAD A SOFT PLACE TO LAND INC | Greer | P12 Human Services | $635k | 1 |
| Charleston Co Vol Rescue Squad Inc | North Charleston | M23Z Public Safety, Disaster Preparedness & Relief | $633k | 0 |
| FOUNTAIN INN MUSEUM INCORPORATED | Fountain Inn | A50 Arts, Culture & Humanities | $632k | 0 |
| SANDALWOOD COMMUNITY FOOD PANTRY | Hilton Head Island | K31 Food, Agriculture & Nutrition | $631k | 1 |
| DARLINGTON COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $631k | 1 |
| COASTAL EXPEDITIONS FOUNDATION | Mt Pleasant | C30 Environment | $630k | 0 |
| SOUTH CAROLINA POLICY COUNCIL EDUCATION FOUNDATION | Columbia | — | $628k | 0 |
| SUMTER BOARD OF REALTORS INC | Sumter | — | $627k | 1 |
| SC DELTA HOUSING CORPORATION | Blythewood | B83 Education | $627k | 0 |
| South Carolina Assocation of Independent Home Schools | Columbia | — | $627k | 0 |
| Flourish Adoption Ministries Inc | Greenville | B90 Education | $624k | 1 |
| OCONEE COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $624k | 1 |
| MOST WORSHIPFUL PRINCE HALL GRAND LODGE OF SOUTH CAROLINA | Columbia | — | $623k | 14 |
| SOUTH CAROLINA ASSOCIATION OF VETERINARIANS | Columbia | — | $623k | 0 |
| ANDERSON COUNTY ARTS COUNCIL | Anderson | A26Z Arts, Culture & Humanities | $623k | 1 |
| Harmony School | Columbia | — | $622k | 0 |
| AIKEN CENTER FOR THE ARTS INC | Aiken | A400 Arts, Culture & Humanities | $622k | 1 |
| LAKESIDE COUNTRY CLUB OF LAURENS COUNTY | Laurens | — | $622k | 0 |
| BEAUFORT COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $621k | 0 |
| Balmer Foundation | Spartanburg | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $621k | 0 |
| MILL TOWN PLAYERS | Pelzer | A20 Arts, Culture & Humanities | $621k | 0 |
| UNIVERSITY MEDICAL ASSOCIATES RETIREE BENEFIT TRUST | Charleston | Y43 Mutual & Membership Benefit | $621k | 1 |
| School Ministries Inc | Columbia | B99Z Education | $621k | 0 |
| SLATER MARIETTA HEALTH AND HUMAN SERVICES INC | Slater | — | $621k | 1 |
| UNION COUNTY YMCA | Union | P27Z Human Services | $620k | 1 |
| WARRIOR SURF FOUNDATION | Folly Beach | W30 Public & Societal Benefit | $619k | 1 |
| Benevolent Protective Order of Sumter 855 | Manning | — | $619k | 0 |
| FRIENDS OF THE HUNLEY INC | North Charleston | A99 Arts, Culture & Humanities | $618k | 0 |
| AMERICAN INSTITUTE OF ARCHITECTS SC CHAPTER | Columbia | — | $618k | 1 |
| Fisher House of Columbia Sc Inc | Columbia | P40 Human Services | $617k | 0 |
| LAKEVIEW CLUB INC | Hartsville | — | $615k | 2 |
| LOVE IN ACTION INTERNATIONAL MINISTRIES | Summerville | X200 Religion-Related | $615k | 0 |
| Follow Protocol Foundation | Simpsonville | W50 Public & Societal Benefit | $615k | 0 |
| HISTORIC BEAUFORT FOUNDATION | Beaufort | A82Z Arts, Culture & Humanities | $614k | 1 |
| ANIMAL PROTECTION LEAGUE OF SOUTH CAROLINA | West Columbia | D200 Animal-Related | $614k | 0 |
| FAMILY PROMISE OF THE MIDLANDS INC | Columbia | P85 Human Services | $614k | 1 |
| CHEROKEE COUNTY MEALS ON WHEELS | Gaffney | K36Z Food, Agriculture & Nutrition | $614k | 0 |
| POTTER HOUSE RECOVERY | Florence | F20 Mental Health & Crisis Intervention | $613k | 3 |
| SUMMERVILLE HOME EDUCATORS | Summerville | — | $611k | 0 |
| MCDOWELL HOUSING CORPORATION | Greenville | L20Z Housing & Shelter | $611k | 0 |
| MARLBORO COUNTY GENERAL HOSPITAL | Bennettsville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $611k | 0 |
| SANTEE ELECTRIC TRUST | Kingstree | T00Z Philanthropy, Voluntarism & Grantmaking Foundations | $610k | 0 |
| South Carolina Technical College System Foundation | Columbia | B30J Education | $609k | 1 |
| Horry-Georgetown Home Builders Assoc | Conway | — | $608k | 1 |
| LEGACY ADVANCEMENT | Greenville | B12 Education | $608k | 1 |
| ANDERSON COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $608k | 0 |
| THE FRANKLIN G BURROUGHS SIMEON B CHAPIN ART MUSEUM | Myrtle Beach | A51I Arts, Culture & Humanities | $607k | 1 |
| North Charleston Dental Outreach Inc | North Charleston | G40 Diseases, Disorders & Medical Disciplines | $607k | 1 |
