| NEW BEGINNINGS | Lewiston | P700 Human Services | $4.1M | 3 |
| Camp Newfound Owatonna Corporation | Harrison | N200 Recreation & Sports | $4.1M | 1 |
| Central Lincoln County Young Mens Christian Association Inc | Damariscotta | P27Z Human Services | $4M | 1 |
| ADCARE EDUCATIONAL INSTITUTE | Augusta | F20 Mental Health & Crisis Intervention | $4M | 2 |
| Safe Voices | Auburn | — | $4M | 3 |
| THE SANDY RIVER CHARITABLE FOUNDATION | Farmington | J32Z Employment | $4M | 1 |
| MAINE IMMIGRANT AND REFUGEE SERVICES | Lewiston | P20 Human Services | $4M | 1 |
| DAY ONE | Windham | F20Z Mental Health & Crisis Intervention | $4M | 2 |
| SAM L COHEN FOUNDATION | Portland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 5 |
| IGNITE PRESQUE ISLE | Presque Isle | S32 Community Improvement & Capacity Building | $3.9M | 1 |
| COMMONSENSE HOUSING INC | Eddington | P730 Human Services | $3.9M | 1 |
| Acadia Center | Rockport | C350 Environment | $3.9M | 5 |
| YESTERDAY'S CHILDRENINC | Ellsworth | P73Z Human Services | $3.9M | 0 |
| SCHOODIC INSTITUTE AT ACADIA NATIONAL | Winter Harbor | C30 Environment | $3.9M | 1 |
| MAINE MATHEMATICS & SCIENCE ALLIANCE | Augusta | B90 Education | $3.9M | 2 |
| Senator George J Mitchell Scholarship | Portland | B82 Education | $3.9M | 2 |
| Maine Cancer Foundation | Falmouth | H30Z Medical Research | $3.8M | 2 |
| BOYS&GIRLS CLUBS OF KENNEBEC VALLEY | Gardiner | O20 Youth Development | $3.8M | 2 |
| YOUNG MENS CHRISTIAN ASSOCIATION | Sanford | — | $3.8M | 1 |
| THE HURRICANE ISLAND FOUNDATION | Rockland | O50 Youth Development | $3.8M | 0 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF AUBURN-LEWISTON | Auburn | P27Z Human Services | $3.8M | 1 |
| Children's Odyssey | Portland | B210 Education | $3.8M | 3 |
| THE NORTHERN LIGHTHOUSE INC | Presque Isle | P32 Human Services | $3.7M | 2 |
| Sanford-Springvale Historical Society | Springvale | A54 Arts, Culture & Humanities | $3.7M | 0 |
| THE LITTLE DOLPHIN SCHOOL FOUNDATIO | Westbrook | B21 Education | $3.7M | 2 |
| REGIONAL TRANSPORTATION PROGRAM | Westbrook | P52Z Human Services | $3.6M | 1 |
| NEW ENGLAND MUSIC CAMP ASSOCIATION | Sidney | — | $3.6M | 2 |
| ISLANDS COMMUNITY MEDICAL SERVICES | Vinalhaven | E32Z Health Care | $3.6M | 7 |
| Eastport Memorial Hospital | Eastport | E92Z Health Care | $3.6M | 4 |
| DAVIS EDUCATIONAL FOUNDATION | Yarmouth | B120 Education | $3.6M | 8 |
| Acadia Academy | Lewiston | B29 Education | $3.6M | 1 |
| WESTBROOK DEVELOPMENT CORPORATION | Westbrook | — | $3.6M | 0 |
| State Street Housing Preservation Corp | Portland | L20Z Housing & Shelter | $3.5M | 0 |
| LifeFlight Foundation | Augusta | E62 Health Care | $3.5M | 0 |
| MAINE PRIMARY CARE ASSOCIATION | Augusta | E70Z Health Care | $3.5M | 5 |
| LEGAL SERVICES FOR MAINE ELDERS | Augusta | I80Z Crime & Legal-Related | $3.5M | 2 |
| NAMI MAINE | Hallowell | F30 Mental Health & Crisis Intervention | $3.5M | 2 |
| ALFOND YOUTH & COMMUNITY CENTER | Waterville | O99 Youth Development | $3.5M | 3 |
| CAFE INC | Westbrook | P820 Human Services | $3.4M | 1 |
| Star of Hope Inc | Rockland | A99 Arts, Culture & Humanities | $3.4M | 0 |
| HABITAT FOR HUMANITY OF GREATER PORTLAND | Portland | — | $3.4M | 1 |
| The Catholic Foundation of Maine | Portland | X122 Religion-Related | $3.4M | 4 |
| CENTER FOR FURNITURE CRAFTSMANSHIP | Rockport | B99 Education | $3.4M | 1 |
| COAST LINE CREDIT UNION | South Portland | — | $3.4M | 2 |
| MAINE TOURISM ASSOCIATION | Hallowell | — | $3.4M | 1 |
| BATH HOUSING DEVELOPMENT CORPORATION | Bath | L20Z Housing & Shelter | $3.4M | 1 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION | Old Town | P270 Human Services | $3.4M | 0 |
| AMERICAN CIVIL LIBERTIES UNION | Portland | R600 Civil Rights, Social Action & Advocacy | $3.4M | 1 |
| DAVIS CONSERVATION FOUNDATION | Yarmouth | C120 Environment | $3.4M | 5 |
| MAINE ENERGY MARKETERS ASSOCIATION | Brunswick | — | $3.3M | 1 |
