| MaineHealth | Portland | E220 Health Care | $4.1B | 18 |
| Eastern Maine Medical Center Northern Light Eastern Maine Medical Cen | Bangor | E200 Health Care | $1.1B | 29 |
| Martin's Point Generations Advantage Inc | Portland | E99 Health Care | $745.8M | 7 |
| MaineGeneral Health and Affiliates | Augusta | — | $743.2M | 13 |
| MAINE EDUCATION ASSOCIATION BENEFITS TRUST | Augusta | — | $591.8M | 1 |
| The Jackson Laboratory | Bar Harbor | H920 Medical Research | $572.8M | 14 |
| Martin's Point Health Care Inc | Portland | E320 Health Care | $550.1M | 18 |
| CENTRAL MAINE MEDICAL CENTER | Lewiston | E220 Health Care | $513.4M | 20 |
| EASTERN MAINE HEALTHCARE SYSTEMS NORTHERN LIGHT HEALTH | Brewer | — | $440.7M | 66 |
| PRESIDENT & TRUSTEES OF COLBY COLLEGE | Waterville | B420 Education | $379.6M | 19 |
| Bowdoin College | Brunswick | B420 Education | $369.8M | 20 |
| Mercy Hospital Northern Light Mercy Hospital | Portland | E220 Health Care | $328.2M | 22 |
| MAINE COMMUNITY HEALTH OPTIONS | New Gloucester | Y20 Mutual & Membership Benefit | $303.8M | 10 |
| University of New England | Biddeford | B430 Education | $303.4M | 10 |
| St Joseph Hospital | Bangor | E220 Health Care | $238.2M | 12 |
| St Mary's Regional Medical Center | Lewiston | E220 Health Care | $236.2M | 10 |
| Employees of Municipal & Other Public Employers of Maine Health Ins Trust | Augusta | — | $213.4M | 0 |
| York Hospital | York | E220 Health Care | $210.4M | 11 |
| PRESIDENT AND TRUSTEES OF BATES COLLEGE | Lewiston | B420 Education | $192.8M | 16 |
| CIEE Inc | South Portland | Q22 International, Foreign Affairs & National Security | $187.7M | 10 |
| HAROLD ALFOND FOUNDATION | Portland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $171M | 0 |
| THE AROOSTOOK MEDICAL CENTER NORTHERN LIGHT AR GOULD HOSPITAL | Presque Isle | E200 Health Care | $168.5M | 24 |
| REDINGTON-FAIRVIEW GENERAL HOSPITAL | Skowhegan | E220 Health Care | $158.9M | 11 |
| Maine Community Foundation Inc | Ellsworth | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $138.8M | 13 |
| New England Life Care Inc | Scarborough | — | $135.2M | 7 |
| Maine Coast Regional Health Facilities Northern Light Maine Coast Hospital | Ellsworth | E220 Health Care | $117.8M | 22 |
| Mount Desert Island Hospital | Bar Harbor | E22Z Health Care | $114.7M | 10 |
| NorDx | Scarborough | E99 Health Care | $106.8M | 17 |
| Maine Veterans Home | Augusta | E910 Health Care | $106.7M | 8 |
| KahleAustin Family Foundation | Biddeford | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $102.9M | 0 |
| Penobscot Community Health Center | Bangor | E32 Health Care | $102.9M | 12 |
| THE BLUE HORIZONS FOUNDATION | Gorham | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $100.8M | 0 |
| Good Shepherd Food Bank | Auburn | K31Z Food, Agriculture & Nutrition | $99.7M | 6 |
| Maine Guaranteed Access Reinsurance Association | Portland | E800 Health Care | $94.9M | 0 |
| Spurwink Services Inc | Portland | — | $90M | 11 |
| Acadia Hospital Corp Northern Light Acadia Hospital | Brewer | E200 Health Care | $87.9M | 18 |
| Unity Environmental University | New Gloucester | B42Z Education | $86.7M | 7 |
| Husson University | Bangor | B500 Education | $86.2M | 9 |
| JOHN F MURPHY HOMES INC | Auburn | P82Z Human Services | $79.2M | 7 |
| INLAND HOSPITAL NORTHERN LIGHT INLAND HOSPITAL | Waterville | E200 Health Care | $76.9M | 21 |
| MRH Corp Northern Light Mayo Hospital | Brewer | E20 Health Care | $73.7M | 17 |
| NORTHERN MAINE MEDICAL CENTER | Fort Kent | E20Z Health Care | $70.6M | 10 |
| PENQUIS CAP INC | Bangor | P20 Human Services | $66.5M | 8 |
| CENTRAL MAINE HEALTHCARE CORPORATION | Lewiston | E210 Health Care | $66.5M | 22 |
| Sebasticook Valley Health Northern Light Sebasticook Valley Hosp | Pittsfield | E200 Health Care | $62.5M | 18 |
| Down East Community Hospital | Machias | E22 Health Care | $62.3M | 10 |
| University of Maine Foundation | Orono | B110 Education | $60.4M | 7 |
| BRIDGTON HOSPITAL | Bridgton | E220 Health Care | $59M | 11 |
| Androscoggin Home Health Services Inc | Lewiston | E92Z Health Care | $58.7M | 7 |
| Houlton Regional Hospital | Houlton | E22Z Health Care | $58.4M | 10 |
