| BAC LOCAL UNION 15 WELFARE FUND | Kansas City | — | $10.6M | 0 |
| Carmelite Sisters of the Divine Heart of Jesus | St Louis | E91Z Health Care | $10.6M | 1 |
| CEMENT MASONS LOCAL 527 HEALTH & WELFARE TRUST FUND | Bridgeton | — | $10.6M | 0 |
| ASCENSION WISCONSIN FOUNDATION INC | St Louis | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $10.6M | 8 |
| Hospital Industry Data Institute | Jefferson City | — | $10.6M | 9 |
| MOBIUS | Columbia | B70 Education | $10.5M | 1 |
| MERCY HEALTH FOUNDATION ST LOUIS | St Louis | E11 Health Care | $10.5M | 7 |
| International Union Intl UAW Local 249 | Pleasant Valley | — | $10.5M | 20 |
| ROMAN CATHOLIC FOUNDATION OF EASTERN MISSOURI | St Louis | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $10.5M | 2 |
| ROSE BROOKS CENTER INC | Kansas City | Z99Z Unknown | $10.5M | 5 |
| HABITAT FOR HUMANITY OF KANSAS CITY | Kansas City | L20Z Housing & Shelter | $10.5M | 3 |
| CITY GARDEN MONTESSORI SCHOOL | Saint Louis | B99Z Education | $10.5M | 4 |
| PROGRESS IN EDUCATION INC | St Louis | B29 Education | $10.5M | 6 |
| VIA CHRISTI VILLAGE PITTSBURG INC | St Louis | — | $10.5M | 9 |
| COMMUNITY PARTNERSHIP OF THE OZARKS INC | Springfield | S20 Community Improvement & Capacity Building | $10.5M | 2 |
| SAVE INC | Kansas City | — | $10.4M | 3 |
| KANSAS CITY PET PROJECT | Kansas City | D20 Animal-Related | $10.4M | 5 |
| Healthcare Services of the Ozarks Inc | Springfield | E92Z Health Care | $10.3M | 5 |
| VETERANS UNITED FOUNDATION | Columbia | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $10.3M | 0 |
| BOYS CLUB OF GREATER KANSAS CITY | Kansas City | O230 Youth Development | $10.3M | 3 |
| ST LOUIS COMMUNITY FOUNDATION | St Louis | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $10.3M | 9 |
| THE BELLWETHER FOUNDATION | St Louis | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $10.3M | 0 |
| WAYSIDE WAIFS INC | Kansas City | D200 Animal-Related | $10.3M | 6 |
| JOHNSON ROBERT K FOUNDATION-MAIN | Saint Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.3M | 1 |
| PULITZER ARTS FOUNDATION | St Louis | S21Z Community Improvement & Capacity Building | $10.2M | 2 |
| ASCENSION LIVING-LAKESHORE AT SIENA INC | St Louis | — | $10.2M | 8 |
| INTERNATIONAL UNION OF OPERATING ENGINEERS LOCAL 513 | Bridgeton | — | $10.2M | 20 |
| MO-KAN TEAMSTERS HEALTH AND WELFARE FUND | Kansas City | — | $10.2M | 0 |
| KANSAS CITY STREETCAR AUTHORITY | Kansas City | W40 Public & Societal Benefit | $10.2M | 3 |
| Employee Benefit Trust for Retirees of Spire MO Inc Covered by a Collective Bargaining Agr | St Louis | — | $10.1M | 0 |
| ASCENSION ST JOHN FOUNDATION | St Louis | E11 Health Care | $10.1M | 7 |
| Greater Horizons Trust | Kansas City | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $10.1M | 0 |
| Heartland Long Term Acute Care Hospital | St Joseph | E22 Health Care | $10.1M | 11 |
| AMANDA LUCKETT MURPHY HOPEWELL CENTER INC | St Louis | F30Z Mental Health & Crisis Intervention | $10.1M | 10 |
| WORLD WIDE TECHNOLOGY FOUNDATION | St Louis | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10M | 0 |
| LOU FUSZ SOCCER CLUB | Earth City | N60Z Recreation & Sports | $10M | 3 |
| Big Brothers Big Sisters Kansas City | Kansas City | — | $10M | 5 |
| PAINTERS DISTRICT COUNCIL #58 | St Louis | — | $9.9M | 20 |
| FOX PERFORMING ARTS CHARITABLE FOUNDATION | St Louis | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $9.9M | 1 |
| WHIMSADOODLE INC | Kansas City | A20 Arts, Culture & Humanities | $9.9M | 3 |
| MAKE-A-WISH FOUNDATION OF MISSOURI AND KANSAS | Ballwin | P99Z Human Services | $9.9M | 4 |
| NATIONAL RURAL HEALTH ASSOCIATION | Kansas City | — | $9.9M | 8 |
| MISSION ST LOUIS | St Louis | S20 Community Improvement & Capacity Building | $9.9M | 3 |
| METROPOLITAN LUTHERAN MINISTRY | Kansas City | — | $9.8M | 2 |
| CATHOLIC CHARITIES OF SOUTHERN MISSOURI INC | Springfield | P20 Human Services | $9.8M | 3 |
| NOVA CENTER INC | Kansas City | P80Z Human Services | $9.8M | 3 |
| LIFE INC | Farmington | P30 Human Services | $9.8M | 1 |
| CREATIVE CONCEPTS FOR LIVING INC | Hazelwood | P80 Human Services | $9.7M | 0 |
| DELLA LAMB COMMUNITY SERVICES | Kansas City | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $9.7M | 2 |
| MOTHER OF PERPETUAL HELP RESIDENCE INC | St Louis | — | $9.7M | 4 |
