| PEQUENO CAMPEON DE JESUS INC | Barceloneta | B28 Education | $5.7M | 1 |
| Atenas University Dr Maria Luisa Hernandez Inc | Manati | B40 Education | $5.6M | 1 |
| VOCES COALICION DE INMUNIZACION Y PROMOCIION DE LA SALUD INC | Guaynabo | Q33 International, Foreign Affairs & National Security | $5.5M | 3 |
| ATENAS COMMUNITY HEALTH CENTER ACHC INC | Manati | E210 Health Care | $5.4M | 10 |
| COLEGIO RADIANS INC | Cayey | B200 Education | $5.3M | 1 |
| COOPERATIVA DE AHORRO Y CREDITO INDUSTRIA BIOFARMACEUTICA | Carolina | — | $5.2M | 5 |
| THE LUIS A FERRE FOUNDATION INC | San Juan | A510 Arts, Culture & Humanities | $5.2M | 3 |
| ALIANZA PARA UN PUERTO RICO SIN DROGAS INC | San Juan | P50Z Human Services | $5.2M | 1 |
| ASOCIACION PRO JUVENTUD Y COMUNIDAD DE BARRIO PALMAS INC | Catano | S20M Community Improvement & Capacity Building | $5M | 1 |
| COLEGIO PUERTORRIQUEO DE NIAS | Guaynabo | B20 Education | $4.9M | 0 |
| PLATFORM FOR SOCIAL IMPACT INC | Carolina | S31 Community Improvement & Capacity Building | $4.9M | 3 |
| ACS OF PUERTO RICO INC | Hato Rey | — | $4.9M | 2 |
| HEALTHCARE INTEGRATED PROGRAM SERVICES INC | Humacao | E30 Health Care | $4.7M | 0 |
| HOGAR RUTH PARA MUJERES MALTRATADAS INC | Vega Alta | — | $4.7M | 1 |
| FOUNDATION FOR PUERTO RICO INC | San Juan | S20 Community Improvement & Capacity Building | $4.5M | 4 |
| SOCIAL HOLDING FOUNDATION CORPORATION | San Juan | O11 Youth Development | $4.5M | 0 |
| TALLER SALUD INC | Loiza | Z99Z Unknown | $4.5M | 3 |
| COMPREHENSIVE HUMAN SERVICES CORPORATION | Guaynabo | E320 Health Care | $4.4M | 10 |
| COOPERATIVA DE AHORRO Y CREDITO DE FLORIDA | Florida | — | $4.3M | 3 |
| Teen Challenge de Puerto Rico Inc | Bayamon | O50 Youth Development | $4.3M | 1 |
| HABITAT FOR HUMANITY INTERNATIONAL PR LLC | San Juan | — | $4.3M | 6 |
| HOGAR MANUEL MEDIAVILLA NEGRON INC | Humacao | L22 Housing & Shelter | $4.2M | 1 |
| CARIBBEAN SCHOOL INC CARIBBEAN SCHOOL INC | Ponce | — | $4.1M | 2 |
| FUNDACION SILA M CALDERON INC | San Juan | P052 Human Services | $4.1M | 7 |
| CENTRO DE ECONOMIA CREATIVA INC | San Juan | S02 Community Improvement & Capacity Building | $4.1M | 2 |
| FUNDACION STEFANO STEENBAKKERS BETANCOURT CORP | Bayamon | P20 Human Services | $4.1M | 0 |
| MUSEO DE ARTE CONTEMPORANEO DE PUERTO RICO INC | San Juan | — | $4M | 1 |
| KINESIS INC | San Juan | O50 Youth Development | $4M | 1 |
| PUERTO RICO COLLEGE OF PHYSICIANS AND SURGEONS | San Juan | E03 Health Care | $4M | 1 |
| ASOCIACION DE INDUSTRIALES DE PUERTO RICO | San Juan | S41 Community Improvement & Capacity Building | $3.9M | 2 |
| CENTRO DE ADULTOS Y NINOS CON IMPEDIMENTOS INC | Isabela | P30 Human Services | $3.8M | 1 |
| CENTRO MARGARITA INC | Cidra | P80 Human Services | $3.8M | 1 |
| LA PERLA DE GRAN PRECIO INC | San Juan | F22Z Mental Health & Crisis Intervention | $3.7M | 6 |
| CARAS OF THE AMERICAS | San Juan | Q20 International, Foreign Affairs & National Security | $3.7M | 1 |
| INSTITUTO PREVOCACIONAL E INDUSTRIAL DE PUERTO RICO | Arecibo | — | $3.7M | 0 |
| FUNDACION PUERTORRIQUEA DE LAS HUMANIDADES INC | San Juan | A20 Arts, Culture & Humanities | $3.6M | 1 |
| PUERTO RICO MANUFACTURING EXTENSION PRIMEX INC | San Juan | S43 Community Improvement & Capacity Building | $3.6M | 1 |
| THE YOUNG MENS CHRISTIAN ASSOCIATION OF SAN JUAN | San Juan | N30 Recreation & Sports | $3.5M | 1 |
| PROTECTORES DE CUENCAS INC | Yauco | C32 Environment | $3.5M | 0 |
| COLEGIO DE APRENDIZAJE Y DESARROLLO EDUCATIVO INTEGRADO CORP | Moca | B99 Education | $3.5M | 0 |
| ONE STOP CAREER CENTER OF PR INC | San Juan | B90 Education | $3.4M | 2 |
| World Boxing Organization Inc | San Juan | — | $3.3M | 2 |
| ECOEXPLORATORIO INC | San Juan | A50 Arts, Culture & Humanities | $3.2M | 0 |
| COLEGIO DE EDUCACION ESPECIAL Y REHABILITACION INTEGRAL INC | San Juan | B28 Education | $3.2M | 3 |
| CAMARA DE MERCADEO INDUSTRIA Y DISTRIBUCION DE ALIMENTOS INC | Guaynabo | S46 Community Improvement & Capacity Building | $3.1M | 1 |
| UNIVERSAL TECHNOLOGY COLLEGE OF PR INC | Aguadilla | B30 Education | $3.1M | 1 |
| National Talent Academy Inc | San Juan | B25 Education | $3.1M | 1 |
| MULE FAMILY FOUNDATION | Dorado | T99Z Philanthropy, Voluntarism & Grantmaking Foundations | $3M | 0 |
| CARIBBEAN COASTAL OCEAN OBSERVING SYSTEM INC | Lajas | U21 Science & Technology | $3M | 3 |
| CENTRO UNIDO DE DETALLISTAS DE PR | San Juan | S40 Community Improvement & Capacity Building | $2.8M | 0 |
