| COOPERATIVA DE AHORRO Y CREDITO DR M ZENO GANDIA | Arecibo | — | $16.4M | 3 |
| COOPERATIVA DE AHORRO Y CREDITO SAN RAFAEL | Quebradillas | — | $15.7M | 3 |
| THE BALDWIN SCHOOL OF PUERTO RICO | Bayamon | B20 Education | $15.6M | 2 |
| ATLANTIC UNIVERSITY INC | Guaynabo | B43 Education | $15.5M | 7 |
| SAINT JOHN'S SCHOOL | San Juan | B20Z Education | $15.4M | 1 |
| COOPERATIVA DE AHORRO Y CREDITO MAUNABO | Maunabo | — | $15.2M | 12 |
| COOPERATIVA DE AHORRO Y CREDITO DE LARES y REGION CENTRAL | Lares | — | $15M | 9 |
| ASOCIACION HOSPITAL DEL MAESTRO INC | San Juan | E20 Health Care | $14.9M | 0 |
| FONDO PERMANENTE PARA LA ADMINISTRA | Salinas | N40 Recreation & Sports | $13.9M | 0 |
| ACCION SOCIAL DE PUERTO RICO INC | Guaynabo | J20Z Employment | $13.4M | 4 |
| Robinson School Inc | San Juan | B25 Education | $13.3M | 2 |
| HABITAT FOR HUMANITY INTERNATIONAL | San Juan | — | $13.3M | 6 |
| DEWEY UNIVERSITY INC | San Juan | B300 Education | $13M | 15 |
| Saint Francis School | Carolina | B20 Education | $12.9M | 3 |
| ALIANZA DE CENTROS DE SALUD COMUNITARIA INC | Guaynabo | S41 Community Improvement & Capacity Building | $12.6M | 2 |
| COOPERATIVA DE AHORRO Y CREDITO DE AIBONITENA | Aibonito | — | $12.5M | 3 |
| COMITE OLIMPICO DE PR INC | San Juan | — | $12.3M | 1 |
| INSTITUTO MODELO ENSENANZA INDIVIDUALIZADA INC | San Juan | B20 Education | $12.2M | 5 |
| CORPORACION EDUCATIVA RAMON BARQUIN | Guaynabo | Z99Z Unknown | $12.2M | 4 |
| CARIBBEAN CONSOLIDATED SCHOOLSINC | San Juan | B25 Education | $12.1M | 3 |
| ALIANZA PARA LA EDUCACION ALTERNATIVA INC | San Juan | B90 Education | $12M | 1 |
| PLATFORM FOR SOCIAL IMPACT INC | Carolina | S31 Community Improvement & Capacity Building | $10.9M | 2 |
| COLEGIO CATOLICO NOTRE DAME CORP | Caguas | B25 Education | $10.5M | 1 |
| GRUPO NEXOS INC | San Juan | V05 Social Science | $10.3M | 0 |
| COOPERATIVA DE AHORRO Y CREDITO CRISTOBAL RODRIGUEZ HIDALGO | Coamo | — | $10.2M | 3 |
| COOPERATIVA DE AHORRO Y CREDITO HATILLO | Hatillo | — | $10.1M | 3 |
| CENTRO DE AYUDA Y TERAPIA AL NINO CON IMPEDIMENTO INC | Moca | E500 Health Care | $9.7M | 1 |
| UNIVERSIDAD CENTRAL DE BAYAMON INC | Bayamon | — | $9.3M | 27 |
| CENTRO PARA LA RECONSTRUCCION DEL HABITAT | San Juan | S20 Community Improvement & Capacity Building | $9.1M | 0 |
| CORPORACION LA FONDITA DE JESUS | San Juan | — | $9.1M | 1 |
| FONDOS UNIDOS DE PUERTO RICO INC & UNITED WAY PUERTO RICO | San Juan | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $8.8M | 5 |
| INSTITUTO NUEVA ESCUELA | San Juan | B90 Education | $8.6M | 0 |
| HOGAR CREA INC | Trujillo Alto | P20 Human Services | $8.2M | 4 |
| INVEST PUERTO RICO INC | San Juan | S30 Community Improvement & Capacity Building | $8.1M | 0 |
| PROGRAMA DE EDUCACION COMUNAL DE ENTREGA Y SERVICIO INC | Humacao | P20Z Human Services | $8M | 9 |
| SOCIEDAD DE EDUCACION Y REHABILITACION SER DE P R | San Juan | E50 Health Care | $7.6M | 1 |
| Cdt Gmsp Inc | Bayamon | E30 Health Care | $7.2M | 1 |
| COMMUNITY HEALTH FOUNDATION OF PUERTO RICO | Bayamon | E30 Health Care | $7.1M | 0 |
| COOPERATIVA DE AHORRO Y CREDITO DE FLORIDA | Florida | — | $6.8M | 3 |
| COOPERATIVA DE AHORRO Y CREDITO MOROVENA | Morovis | — | $6.7M | 4 |
| VOCES COALICION DE INMUNIZACION Y PROMOCIION DE LA SALUD INC | Guaynabo | Q33 International, Foreign Affairs & National Security | $6.7M | 3 |
| HABITAT FOR HUMANITY OF PUERTO RICO INC | San Juan | — | $6.6M | 1 |
| ASPIRA INC DE PUERTO RICO | San Juan | — | $6.6M | 0 |
| AMERICAN COLLEGE OF PUERTO RICO INC | Bayamon | B42Z Education | $6.3M | 1 |
| MUSEO DE ARTE DE PUERTO RICO INC | San Juan | A510 Arts, Culture & Humanities | $6M | 0 |
| COOPERATIVA AHORRO Y CREDITO PEPINIANA | San Sebastian | — | $5.9M | 3 |
| COLEGIO DE INGENIEROS Y | San Juan | — | $5.8M | 2 |
| COLEGIO SAN JOSE MARIANIST CORP | San Juan | B25 Education | $5.7M | 3 |
| PEQUENO CAMPEON DE JESUS INC | Barceloneta | B28 Education | $5.7M | 1 |
| Atenas University Dr Maria Luisa Hernandez Inc | Manati | B40 Education | $5.6M | 1 |
