| EAST CENTRAL MH & CD CENTER INC | Brookings | F30Z Mental Health & Crisis Intervention | $4M | 0 |
| PINE ROCK FOUNDATION INC | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 4 |
| BROOKINGS HEALTH SYSTEM INVESTMENT AUTHORITY | Brookings | E60 Health Care | $3.9M | 2 |
| SENIOR CITIZEN SERVICES INC DBA ACTIVE GENERATIONS | Sioux Falls | P81Z Human Services | $3.9M | 2 |
| YOUTH & FAMILY SERVICES FOUNDATION | Rapid City | P11 Human Services | $3.8M | 1 |
| EXPERIENCE SIOUX FALLS | Sioux Falls | S41 Community Improvement & Capacity Building | $3.8M | 1 |
| KINGSBURY ELECTRIC COOPERATIVE INC | De Smet | — | $3.8M | 8 |
| WATERTOWN DEVELOPMENT COMPANY | Watertown | — | $3.7M | 1 |
| SOUTH CENTRAL CHILD DEVELOPMENT INC | Wagner | — | $3.7M | 2 |
| TEKAKWITHA NURSING CENTER | Sisseton | — | $3.7M | 3 |
| WESKOTA MANOR INC | Wessington Springs | E910 Health Care | $3.7M | 1 |
| FRANK W VEDEN CHARITABLE TRUST | Sioux Falls | T22J Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 3 |
| NE SOUTH DAKOTA COMMUNITY ACTION PROGRAM INC | Sisseton | — | $3.7M | 5 |
| SOUTH DAKOTA ASSOCIATION OF RURAL WATER SYSTEMS | Madison | — | $3.6M | 2 |
| Clay Rural Water System Inc | Wakonda | — | $3.6M | 10 |
| LEMMON AREA MEDICAL ASSOCIATION | Lemmon | E22 Health Care | $3.6M | 1 |
| Community Transit of Watertown Sisseton Inc | Watertown | W40 Public & Societal Benefit | $3.6M | 2 |
| NORTHEAST SOUTH DAKOTA HEAD START PROGRAM INC | Aberdeen | — | $3.6M | 2 |
| South Eastern Development Foundation | Sioux Falls | S32 Community Improvement & Capacity Building | $3.6M | 0 |
| SOUTH DAKOTA RURAL ELECTRIC ASSOCIATION | Pierre | — | $3.6M | 36 |
| THE HURON CLINIC FOUNDATION LTD | Huron | E110 Health Care | $3.6M | 5 |
| SOUTH DAKOTA BEEF INDUSTRY COUNCIL INC | Pierre | — | $3.6M | 1 |
| LARSON FOUNDATION | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 1 |
| VISIT RAPID CITY | Rapid City | S41 Community Improvement & Capacity Building | $3.5M | 1 |
| ICE SPORTS ASSOCIATION DBA SCHEELS ICEPLEX | Sioux Falls | O20 Youth Development | $3.5M | 1 |
| CHRISTIAN WORSHIP HOUR | Aberdeen | — | $3.4M | 0 |
| SOUTH DAKOTA FARM BUREAU FEDERATION | Huron | — | $3.4M | 2 |
| DOUGLAS ELECTRIC COOPERATIVE INC | Armour | — | $3.4M | 6 |
| WESTERN SOUTH DAKOTA SENIOR SERVICES INC | Rapid City | — | $3.3M | 2 |
| KADOKA NURSING HOME ASSOCIATION | Kadoka | E91Z Health Care | $3.3M | 4 |
| OAHE YOUNG MEN'S CHRISTIAN ASSOCIATION | Pierre | P270 Human Services | $3.3M | 2 |
| SOUTH DAKOTA PARTNERS IN EDUCATION | Sioux Falls | B82 Education | $3.3M | 1 |
| Mni Waste' Water Company | Eagle Butte | Y11 Mutual & Membership Benefit | $3.3M | 8 |
| SUNNYCREST VILLAGE INC | Sioux Falls | L22Z Housing & Shelter | $3.3M | 2 |
| CHEYENNE RIVER YOUTH PROJECT INC | Eagle Butte | O50 Youth Development | $3.3M | 1 |
| STRIDER EDUCATION FOUNDATION INC | Rapid City | O50 Youth Development | $3.2M | 1 |
| Joint Well Field Inc | Toronto | Y22 Mutual & Membership Benefit | $3.2M | 5 |
| CH ROBINSON WORLDWIDE FOUNDATION | Sioux Falls | B82 Education | $3.2M | 0 |
| DIAMOND WILLOW MINISTRIES | Fort Thompson | P60 Human Services | $3.2M | 0 |
| CALL TO FREEDOM | Sioux Falls | P62 Human Services | $3.2M | 2 |
| OAHE CHILD DEVELOPMENT CENTER INC | Pierre | B22Z Education | $3.2M | 2 |
| LUTHERANS OUTDOORS IN SOUTH DAKOTA INC | Sioux Falls | — | $3.2M | 0 |
| SOUTH DAKOTA EDUCATION ASSOCIATION | Pierre | — | $3.1M | 4 |
| NATIONAL MUSIC MUSEUM (AMERICAS SHRINE TO MUSIC) | Vermillion | A540 Arts, Culture & Humanities | $3.1M | 0 |
| BEAR BUTTE VALLEY WATER INC | Sturgis | K20 Food, Agriculture & Nutrition | $3.1M | 0 |
| MOUNT RUSHMORE NATIONAL MEMORIAL SOCIETY | Rapid City | — | $3.1M | 3 |
| RAFT CHARITABLE FOUNDATION | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.1M | 1 |
| WILMOT CARE CENTER | Wilmot | E91 Health Care | $3.1M | 1 |
| SD ASSOCIATION OF HEALTHCARE ORGANIZATIONS | Sioux Falls | — | $3.1M | 4 |
| AURORA-BRULE RURAL WATER SYSTEM | Kimball | — | $3M | 6 |
