| Jewish Community Alliance | Portland | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $5.3M | 1 |
| MAINE FARMLAND TRUST | Belfast | K25 Food, Agriculture & Nutrition | $5.2M | 2 |
| Rocking Moon Foundation Inc | Yarmouth | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.2M | 0 |
| Alternative Health Services | Bangor | E92Z Health Care | $5.2M | 11 |
| MAINE MOTOR TRANSPORT ASSOCIATION | Augusta | — | $5.2M | 2 |
| Children's Center Early Intervention & | Augusta | G23Z Diseases, Disorders & Medical Disciplines | $5.1M | 1 |
| MILESTONE RECOVERY | Portland | F22Z Mental Health & Crisis Intervention | $5.1M | 1 |
| BILL AND JOAN ALFOND | Portland | — | $5.1M | 0 |
| Victoria Mansion | Portland | A82Z Arts, Culture & Humanities | $5.1M | 1 |
| CARING FAMILIES INC | Portland | L80 Housing & Shelter | $5.1M | 0 |
| Maine Workers Compensation Policyholder Trust | Augusta | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $5.1M | 1 |
| KENNEBEC MENTAL HEALTH ASSOCIATES | Waterville | F110 Mental Health & Crisis Intervention | $4.9M | 8 |
| NORTHEAST HARBOR SAILING SCHOOL | Northeast Harbor | N114 Recreation & Sports | $4.9M | 0 |
| Community Regional Charter School | Skowhegan | B20 Education | $4.9M | 1 |
| ELMHURST INC | Bath | G200 Diseases, Disorders & Medical Disciplines | $4.9M | 3 |
| Wings for Children and Families Inc | Bangor | F30 Mental Health & Crisis Intervention | $4.9M | 0 |
| Odd Fellows and Rebekahs' Home of Maine | Auburn | P750 Human Services | $4.9M | 1 |
| The Lincoln Home | Newcastle | P750 Human Services | $4.8M | 1 |
| Amicus | Bangor | P700 Human Services | $4.8M | 1 |
| SPECIAL OLYMPICS MAINE INC | South Portland | N72Z Recreation & Sports | $4.8M | 2 |
| Northern New England Employment Services | Gorham | J30 Employment | $4.8M | 0 |
| THE MAINE SPECIAL EDUCATIONMENTAL | New Gloucester | B28 Education | $4.8M | 4 |
| MOBIUS INC | Damariscotta | P73 Human Services | $4.7M | 2 |
| Great Schools Partnership Inc | Portland | B20 Education | $4.7M | 7 |
| BAXTER ACADEMIES OF MAINE | Portland | B29 Education | $4.7M | 4 |
| Greater Brunswick Housing Corporation | Brunswick | L80 Housing & Shelter | $4.7M | 2 |
| Coastal Opportunities | Camden | — | $4.7M | 2 |
| 3i Housing of Maine | Topsham | L24 Housing & Shelter | $4.6M | 2 |
| USM OSHER MAP LIBRARY FOUNDATION | Portland | — | $4.6M | 1 |
| Crossroads for Women Inc | Scarborough | F220 Mental Health & Crisis Intervention | $4.6M | 1 |
| Maine Media College | Rockport | — | $4.6M | 2 |
| DOWNEAST TRANSPORTATION INC | Ellsworth | — | $4.6M | 1 |
| MAINE MEDICAL ASSOCIATION | Manchester | — | $4.6M | 1 |
| DISABILITY RIGHTS MAINE | Augusta | I80Z Crime & Legal-Related | $4.6M | 2 |
| The Owls Head Transportation Museum | Owls Head | A570 Arts, Culture & Humanities | $4.5M | 1 |
| Maine Pretrial Services | Portland | — | $4.5M | 0 |
| Coastal Rivers Conservation Trust | Damariscotta | C320 Environment | $4.5M | 1 |
| Harrington Family Health Center Inc | Harrington | E32 Health Care | $4.5M | 7 |
| St Mary's Health System | Lewiston | E210 Health Care | $4.5M | 9 |
| MAINE JUSTICE FOUNDATION | Augusta | I800 Crime & Legal-Related | $4.4M | 1 |
| Natural Resources Council of Maine Inc | Augusta | C300 Environment | $4.4M | 5 |
| WATERVILLE CREATES | Waterville | A200 Arts, Culture & Humanities | $4.4M | 3 |
| PAN ATLANTIC FOUNDATION | Portland | Q22 International, Foreign Affairs & National Security | $4.4M | 3 |
| SOUTH PORTLAND HOUSING DEVELOPMENT CORP | South Portland | L22 Housing & Shelter | $4.3M | 0 |
| PORTLAND MAINE SYMPHONY ORCHESTRA | Portland | A690 Arts, Culture & Humanities | $4.3M | 2 |
| Maine Audubon Society | Falmouth | C27 Environment | $4.3M | 3 |
| SABATTUS REGIONAL CREDIT UNION | Sabattus | — | $4.3M | 1 |
| SUNRISE COUNTY ECONOMIC COUNCIL | Machias | S31Z Community Improvement & Capacity Building | $4.2M | 2 |
| Southern Maine Planning and Development | Saco | Z99Z Unknown | $4.1M | 1 |
| YORK GOLF AND TENNIS CLUB INC | York | — | $4.1M | 4 |
