| MOBIUS INC | Damariscotta | P73 Human Services | $4.5M | 2 |
| Harrington Family Health Center Inc | Harrington | E32 Health Care | $4.5M | 7 |
| St Mary's Health System | Lewiston | E210 Health Care | $4.5M | 9 |
| BILL AND JOAN ALFOND FAMILY FOUNDATION | Portland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| MAINE JUSTICE FOUNDATION | Augusta | I800 Crime & Legal-Related | $4.4M | 1 |
| Natural Resources Council of Maine Inc | Augusta | C300 Environment | $4.4M | 5 |
| WATERVILLE CREATES | Waterville | A200 Arts, Culture & Humanities | $4.4M | 3 |
| SOUTH PORTLAND HOUSING DEVELOPMENT CORP | South Portland | L22 Housing & Shelter | $4.3M | 0 |
| Maine Audubon Society | Falmouth | C27 Environment | $4.3M | 3 |
| YESTERDAY'S CHILDRENINC | Ellsworth | P73Z Human Services | $4.3M | 0 |
| SABATTUS REGIONAL CREDIT UNION | Sabattus | — | $4.3M | 1 |
| SUNRISE COUNTY ECONOMIC COUNCIL | Machias | S31Z Community Improvement & Capacity Building | $4.3M | 2 |
| YORK GOLF AND TENNIS CLUB INC | York | — | $4.3M | 4 |
| YOUNG MENS CHRISTIAN ASSOCIATION SANFORD-SPRINGVALE | Sanford | — | $4.2M | 1 |
| FULL PLATES FULL POTENTIAL | Brunswick | K30 Food, Agriculture & Nutrition | $4.2M | 1 |
| Camp Newfound Owatonna Corporation | Harrison | N200 Recreation & Sports | $4.1M | 1 |
| Dempsey Center for Quality Cancer Care | Lewiston | E30 Health Care | $4.1M | 4 |
| Central Lincoln County Young Mens Christian Association Inc | Damariscotta | P27Z Human Services | $4M | 1 |
| ADCARE EDUCATIONAL INSTITUTE OF MAINE INC | Augusta | F20 Mental Health & Crisis Intervention | $4M | 2 |
| Safe Voices | Auburn | — | $4M | 3 |
| THE SANDY RIVER CHARITABLE FOUNDATION | Farmington | J32Z Employment | $4M | 1 |
| COAST LINE CREDIT UNION | South Portland | — | $4M | 2 |
| Maine Life and Health Insurance Guaranty Association | South China | — | $4M | 0 |
| MAINE IMMIGRANT AND REFUGEE SERVICES | Lewiston | P20 Human Services | $4M | 1 |
| DAY ONE | Windham | F20Z Mental Health & Crisis Intervention | $4M | 2 |
| HABITAT FOR HUMANITY OF GREATER PORTLAND | Portland | — | $3.9M | 1 |
| SAM L COHEN FOUNDATION | Portland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 5 |
| IGNITE PRESQUE ISLE | Presque Isle | S32 Community Improvement & Capacity Building | $3.9M | 1 |
| Acadia Center | Rockport | C350 Environment | $3.9M | 5 |
| Senator George J Mitchell Scholarship Research Institute | Portland | B82 Education | $3.9M | 2 |
| NEW ENGLAND MUSIC CAMP ASSOCIATION | Sidney | — | $3.9M | 2 |
| Maine Cancer Foundation | Falmouth | H30Z Medical Research | $3.8M | 2 |
| BOYS&GIRLS CLUBS OF KENNEBEC VALLEY | Gardiner | O20 Youth Development | $3.8M | 2 |
| THE HURRICANE ISLAND FOUNDATION | Rockland | O50 Youth Development | $3.8M | 0 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF AUBURN-LEWISTON | Auburn | P27Z Human Services | $3.8M | 1 |
| Children's Odyssey | Portland | B210 Education | $3.8M | 3 |
| THE NORTHERN LIGHTHOUSE INC | Presque Isle | P32 Human Services | $3.7M | 2 |
| MORTON-KELLY CHARITABLE TRUST | Portland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 5 |
| DAVIS FAMILY FOUNDATION | Yarmouth | T900 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 6 |
| MIDCOAST HUMANE | Brunswick | D200 Animal-Related | $3.7M | 2 |
| NAMI MAINE | Hallowell | F30 Mental Health & Crisis Intervention | $3.7M | 2 |
| REGIONAL TRANSPORTATION PROGRAM | Westbrook | P52Z Human Services | $3.6M | 1 |
| St Joseph Healthcare Foundation | Bangor | W12 Public & Societal Benefit | $3.6M | 6 |
| ISLANDS COMMUNITY MEDICAL SERVICES | Vinalhaven | E32Z Health Care | $3.6M | 7 |
| Educate Maine | Portland | B05 Education | $3.6M | 1 |
| MAINE RURAL WATER ASSOCIATION | Richmond | — | $3.6M | 1 |
| Eastport Memorial Hospital | Eastport | E92Z Health Care | $3.6M | 4 |
| COMMONSPACE | Portland | E99Z Health Care | $3.6M | 1 |
| Acadia Academy | Lewiston | B29 Education | $3.6M | 1 |
| BANGOR HOUSING DEVELOPMENT CORPORATION | Bangor | — | $3.6M | 1 |
