| Middleton Place Foundation | Charleston | A540 Arts, Culture & Humanities | $2.8M | 7 |
| UNITED WAY OF THE LOWCOUNTRY | Beaufort | — | $2.8M | 1 |
| Midnight Call Inc | Lexington | — | $2.8M | 4 |
| Cure Sanfilippo Foundation | Columbia | H80 Medical Research | $2.8M | 3 |
| FAITH HOME INC | Greenwood | — | $2.8M | 1 |
| Children's Center at USC | Columbia | B21 Education | $2.8M | 0 |
| LAKE CONESTEE DAM RESTORATION FUND INC | White Stone | — | $2.8M | 0 |
| MY SISTER'S HOUSE INC | North Charleston | P430 Human Services | $2.8M | 1 |
| SCAGO EDUCATIONAL FACILITIES CORP FOR CHEROKEE SCHOOL DISTRICT | Greer | B11 Education | $2.8M | 1 |
| SOUTH CAROLINA STATE MUSEUM FOUNDATION | Columbia | A115 Arts, Culture & Humanities | $2.8M | 0 |
| C P LEGACY FOUNDATION OF SUMTER SC INC | Sumter | L22 Housing & Shelter | $2.8M | 0 |
| GREENWOOD-EDGEFIELD-MCCORMICK- ABBEVILLE COMMISSION ON ALCOHOL | Greenwood | F20 Mental Health & Crisis Intervention | $2.8M | 1 |
| EMANUEL-MORRIS BROWN-EBENEZER APARTMENTS INC | West Columbia | — | $2.7M | 0 |
| Partners In Hope Inc | Loris | L21 Housing & Shelter | $2.7M | 0 |
| DORCHESTER PAWS | Summerville | D200 Animal-Related | $2.7M | 1 |
| Sumter Two School Facilities Inc | Sumter | B11 Education | $2.7M | 0 |
| South Carolina Universities Research & Education Foundation | Aiken | — | $2.7M | 1 |
| GREENWOOD CHRISTIAN SCHOOL INC | Greenwood | — | $2.7M | 1 |
| LANCASTER CHILDRENS HOME | Lancaster | — | $2.7M | 0 |
| SELF REGIONAL HEALTHCARE FOUNDATION | Greenwood | — | $2.7M | 0 |
| UNIVERSITY CENTER FACILITIES CORPORATION V | Rock Hill | — | $2.7M | 3 |
| CHOSEN CHILDREN MINISTRIES INC | Inman | P31 Human Services | $2.7M | 1 |
| SCAGO EDUCATIONAL FACILITIES CORP FOR UNION COUNTY SCHOOL DISTRICT | Union | B11 Education | $2.7M | 0 |
| THE FULLERTON FOUNDATION | Gaffney | B82 Education | $2.7M | 14 |
| HABITAT FOR HUMANITY SPARTANBURG I | Spartanburg | L20Z Housing & Shelter | $2.7M | 1 |
| Trent Hill Center for Children & Families | Hartsville | P30 Human Services | $2.7M | 2 |
| Cannon Street YMCA (6094) | Charleston | — | $2.7M | 1 |
| GREENVILLE AREA DEVELOPMENT CORPORATION | Greenville | S113 Community Improvement & Capacity Building | $2.7M | 4 |
| WILLIAMSBURG ACADEMY INC | Kingstree | B24Z Education | $2.7M | 0 |
| SPCA ALBRECHT CENTER FOR ANIMAL WELFARE | Aiken | D200 Animal-Related | $2.7M | 0 |
| CONSERVATION VOTERS OF SC | Columbia | — | $2.7M | 1 |
| FAMILY PRESERVATION COMMUNITY SERVICES INC | Columbia | P32 Human Services | $2.6M | 1 |
| PROJECT REST | Spartanburg | P430 Human Services | $2.6M | 1 |
| The MCA Foundation | Spartanburg | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 0 |
| ROBERT S CAMPBELL FOUNDATION | Greenville | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 1 |
| CHARLESTON DEVELOPMENT ACADEMY | Charleston | B29 Education | $2.6M | 1 |
| ARRAS FOUNDATION | Lancaster | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 12 |
| NORTH CHARLESTON RENAISSANCE INC | North Charleston | L11 Housing & Shelter | $2.6M | 0 |
| HARVESTERS INTERNATIONAL MINISTRIES | Hilton Head | X21 Religion-Related | $2.6M | 2 |
| NARROWAY PRODUCTIONS INC | Fort Mill | X80 Religion-Related | $2.6M | 2 |
| GRASSY POND WATER COMPANY INC | Gaffney | — | $2.6M | 0 |
| COUNCIL OF AUTISM SERVICE PROVIDERS INC | Lexington | S46 Community Improvement & Capacity Building | $2.6M | 3 |
| THE THERAPY PLACE INC | Columbia | O50 Youth Development | $2.6M | 1 |
| The Camp Cole Foundation Inc | Columbia | P20 Human Services | $2.6M | 1 |
| TRICO WATER COMPANY INC | Dillon | — | $2.6M | 6 |
| GATEWAY HOUSE INC | Greenville | F30Z Mental Health & Crisis Intervention | $2.6M | 1 |
| LAURENS ACADEMY INC | Laurens | B20Z Education | $2.6M | 1 |
| South Carolina Association of Pregnancy Care Centers | Aiken | P45 Human Services | $2.6M | 1 |
| BAKALA FOUNDATION USA | Greenville | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 0 |
| Lutheran Homes of South Carolina Foundation | Irmo | P110 Human Services | $2.5M | 5 |
