| SCAGO EFC BEAUFORT COUNTY SCHOOL | Beaufort | B11 Education | $2.5M | 2 |
| EMANUEL-MORRIS BROWN-EBENEZER | West Columbia | — | $2.5M | 0 |
| VERITAS PREPARATORY SCHOOL INC | Greenville | B99 Education | $2.5M | 1 |
| CALHOUN FALLS CHARTER SCHOOL | Calhoun Falls | B29 Education | $2.5M | 1 |
| THE NORTH EASTERN STRATEGIC ALLIANCEINC | Florence | S30 Community Improvement & Capacity Building | $2.5M | 1 |
| Tap Cancer Out Inc | Indian Land | N12 Recreation & Sports | $2.5M | 3 |
| Tamassee DAR School Inc | Tamassee | — | $2.5M | 1 |
| DORCHESTER SENIORS INC | Summerville | P810 Human Services | $2.5M | 2 |
| THE CHURCH MOUSE THRIFT SHOP INC | Hilton Head Island | S12 Community Improvement & Capacity Building | $2.5M | 0 |
| CENTER FOR DEVELOPMENTAL SERVICES | Greenville | P110 Human Services | $2.5M | 1 |
| Charleston Library Society | Charleston | — | $2.5M | 1 |
| HIGH HILLS RURAL WATER CO INC | Dalzell | W80 Public & Societal Benefit | $2.5M | 1 |
| COLUMBIA HOUSING AUTHORITY DEVELOPMENT | Columbia | — | $2.5M | 0 |
| LOWCOUNTRY DAY SCHOOL INC | Pawleys Island | B24Z Education | $2.5M | 1 |
| CAPE ROMAIN ENVIRONMENTAL EDUCATION | McClellanville | B29 Education | $2.5M | 1 |
| Sowing Circle | Greenville | X20M Religion-Related | $2.5M | 4 |
| MARY BLACK FOUNDATION INC | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 2 |
| The Premier Foundation | Greer | X20Z Religion-Related | $2.5M | 1 |
| Clapham Education Group | North Charleston | B24 Education | $2.5M | 1 |
| Hope Inc | Rock Hill | P600 Human Services | $2.5M | 1 |
| AIKEN COUNTY COMMISSION ON ALCOHOL | Aiken | — | $2.5M | 1 |
| GREENWOOD-EDGEFIELD-MCCORMICK- | Greenwood | F20 Mental Health & Crisis Intervention | $2.5M | 1 |
| PET HELPERS INC | Charleston | D200 Animal-Related | $2.4M | 1 |
| WALNUT GROVE CHRISTIAN SCHOOL | Fort Mill | B21 Education | $2.4M | 1 |
| INDIAN WATERS COUNCIL | Columbia | O410 Youth Development | $2.4M | 1 |
| SOUTH CAROLINA MANUFACTURERS ALLIANCE | Columbia | — | $2.4M | 3 |
| ASSOCIATION FOR THE BLIND AND | Charleston | — | $2.4M | 1 |
| HILTON HEAD SYMPHONY ORCHESTRA INC | Hilton Head Island | A690 Arts, Culture & Humanities | $2.4M | 1 |
| Chickasaw Association Inc | Westminster | — | $2.4M | 0 |
| Oakland Club | Pineville | — | $2.4M | 0 |
| DARKNESS TO LIGHT INC | Mt Pleasant | I72 Crime & Legal-Related | $2.4M | 1 |
| The Movement Foundation Inc | Fort Mill | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $2.4M | 4 |
| Dorchester Academy Inc | Saint George | — | $2.4M | 1 |
| Community Development And Improvement | Graniteville | L21 Housing & Shelter | $2.4M | 1 |
| NORTH FLINT REINVESTMENT | Columbia | P20 Human Services | $2.4M | 1 |
| FRONTLINE MISSIONS INTERNATIONAL | Taylors | X21 Religion-Related | $2.4M | 1 |
| PIEDMONT AGENCY ON AGING INC | Greenwood | P81Z Human Services | $2.4M | 1 |
| SC VOCATIONS AND INDIVIDUAL ADVANCEMENT | Greenville | J20 Employment | $2.4M | 3 |
| CONWAY HOSPITAL COMMUNITY SERVICES | Conway | E30 Health Care | $2.4M | 6 |
| MERCY MEDICAL FREE CLINICS | Florence | E30 Health Care | $2.4M | 1 |
| Vital Connections of the Midlands | Columbia | P33 Human Services | $2.4M | 1 |
| SOUTH CAROLINA FARM BUREAU LAND | Cayce | K25 Food, Agriculture & Nutrition | $2.4M | 3 |
| SOUTH CAROLINA ASSOCIATION OF | Cayce | — | $2.4M | 2 |
| The Rebecca C Parsons Foundation | Pawleys Island | — | $2.4M | 3 |
| FREE MEDICAL CLINIC INC | Columbia | E32Z Health Care | $2.4M | 1 |
| Georgetown County Chamber of Commerce Inc | Georgetown | S41 Community Improvement & Capacity Building | $2.4M | 1 |
| GOLDENCARE INC | Lancaster | E91 Health Care | $2.4M | 1 |
| SEA PINES MONTESSORI ACADEMY | Hilton Head Island | — | $2.3M | 1 |
| FACES AND VOICES OF RECOVERY(FAVOR) | Greenville | — | $2.3M | 1 |
| JEANS ANGELS | Moncks Corner | O99 Youth Development | $2.3M | 0 |
