| Georgetown County Chamber of Commerce Inc | Georgetown | S41 Community Improvement & Capacity Building | $2.4M | 1 |
| RECONCILIATION MINISTRIES SC | Columbia | P30 Human Services | $2.4M | 1 |
| GOLDENCARE INC | Lancaster | E91 Health Care | $2.4M | 1 |
| FISHERS OF MEN MINISTRIES INC | Chapin | X21 Religion-Related | $2.3M | 0 |
| HIS WAY AT WORK | Spartanburg | X20 Religion-Related | $2.3M | 4 |
| FACES AND VOICES OF RECOVERY(FAVOR) UPSTATE SC | Greenville | — | $2.3M | 1 |
| JEANS ANGELS | Moncks Corner | O99 Youth Development | $2.3M | 0 |
| CONWAY CHRISTIAN SCHOOL | Conway | B24P Education | $2.3M | 1 |
| CW AND DOROTHY G LOVE FOUNDATION | McColl | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 3 |
| AIKEN COUNTY COMMISSION ON ALCOHOL | Aiken | — | $2.3M | 1 |
| The Ceres Foundation Inc | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 1 |
| UNITED WAY OF PICKENS COUNTY | Easley | — | $2.3M | 1 |
| The Turning Point of South Carolina Inc | Greenville | L41 Housing & Shelter | $2.3M | 0 |
| UNITED WAY OF AIKEN COUNTY INC | Aiken | — | $2.3M | 1 |
| NEIGHBORHOOD CANCER CONNECTION | Greenville | — | $2.3M | 1 |
| HABITAT FOR HUMANITY INTERNATIONAL OCONEE COUNTY HABITAT FOR HUMANITY | Seneca | — | $2.3M | 0 |
| PALMETTOPRIDE THE GOVERNOR'S COUNCIL ON BEAUTIFICATION & LITTER | Columbia | C015 Environment | $2.3M | 1 |
| CHESTER HEALTHCARE FOUNDATION | Chester | E129 Health Care | $2.3M | 0 |
| CAMDEN COUNTRY CLUB | Camden | — | $2.3M | 0 |
| Children's Museum of the Lowcountry | Charleston | A520 Arts, Culture & Humanities | $2.3M | 1 |
| WILDEWOOD COMMUNITY NEIGHBORHOOD INC | Columbia | — | $2.3M | 0 |
| SPRING ISLAND TRUST | Okatie | C30 Environment | $2.3M | 2 |
| NEWBERRY COUNTY COUNCIL ON AGING | Newberry | P81Z Human Services | $2.3M | 1 |
| THE SELF FOUNDATION | Greenwood | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 1 |
| PALMETTO PROJECT INC | North Charleston | — | $2.3M | 2 |
| GREENVILLE ARTS FESTIVAL | Greenville | A20 Arts, Culture & Humanities | $2.3M | 1 |
| PALMETTO EXCEL INC | North Charleston | B29 Education | $2.3M | 1 |
| Keowee Key Utility Systems Inc | Salem | — | $2.3M | 0 |
| THE TUOMEY FOUNDATION | Sumter | E21I Health Care | $2.3M | 1 |
| PARTNERS FOR ACTIVE LIVING | Spartanburg | M40 Public Safety, Disaster Preparedness & Relief | $2.2M | 1 |
| INTERNATIONAL TRANSPORTATION INNOVATION CENTER | Greenville | S30 Community Improvement & Capacity Building | $2.2M | 3 |
| PIEDMONT TECHNICAL COLLEGE FOUNDATION INC | Greenwood | B31I Education | $2.2M | 1 |
| WACCAMAW PARK PUBLIC CHARTER SCHOOLS INC | Myrtle Beach | B29 Education | $2.2M | 1 |
| CLARENDON HALL SCHOOL INC | Summerton | B24 Education | $2.2M | 0 |
| REBUILD UPSTATE | Greenville | X20 Religion-Related | $2.2M | 2 |
| WESTVIEW BEHAVIORAL HEALTH SERVICES | Newberry | — | $2.2M | 1 |
| GRAND STRAND HUMANE SOCIETY INC | Myrtle Beach | D200 Animal-Related | $2.2M | 1 |
| AMERICAN FRIENDS OF ALUMOT OR SASA-SETTON AND CFJI INC | Charleston | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 0 |
| TOGETHER WOMEN RISE | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 1 |
| MENTAL HEALTH AMERICA OF GREENVILLE COUNTY INC | Greenville | F30Z Mental Health & Crisis Intervention | $2.2M | 1 |
| The Sinclair Foundation | Rock Hill | W99 Public & Societal Benefit | $2.2M | 0 |
| SAFE PASSAGE INC | Rock Hill | — | $2.2M | 2 |
| CHARLESTON COALITION FOR KIDS | Charleston | B99 Education | $2.2M | 1 |
| Charles Towne Montessori School | Charleston | — | $2.2M | 1 |
| BARRIER ISLANDS FREE MEDICAL CLINIC | Johns Island | E32 Health Care | $2.2M | 2 |
| Homeless No More Inc | Columbia | L40 Housing & Shelter | $2.2M | 2 |
| DORCHESTER COUNTY COMMUNITY OUTREACH | Summerville | L41 Housing & Shelter | $2.2M | 1 |
| RESTORATION PROJECT FOUNDATION | Anderson | P20 Human Services | $2.2M | 0 |
| COMPETITIVE CHAMPIONS OF THE CAROLINAS | Fort Mill | N70 Recreation & Sports | $2.2M | 2 |
| The Premier Foundation | Greer | X20Z Religion-Related | $2.2M | 1 |
