| CONWAY CHRISTIAN SCHOOL | Conway | B24P Education | $2.3M | 1 |
| CW AND DOROTHY G LOVE FOUNDATION | McColl | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 3 |
| The Ceres Foundation Inc | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 1 |
| PALMETTO GOLF CLUB | Aiken | — | $2.3M | 2 |
| UNITED WAY OF PICKENS COUNTY | Easley | — | $2.3M | 1 |
| NEWBERRY COUNTY COUNCIL ON AGING | Newberry | P81Z Human Services | $2.3M | 1 |
| CITY OF FLORENCE PUBLIC FACILITIES CORPORATION | Florence | S02 Community Improvement & Capacity Building | $2.3M | 0 |
| FISHERS OF MEN MINISTRIES INC | Chapin | X21 Religion-Related | $2.3M | 2 |
| SOUTH CAROLINA FIRST STEPS TO SCHOOL READINESS - LANCASTER COUNTY | Greenwood | B012 Education | $2.3M | 0 |
| MENTAL HEALTH AMERICA OF GREENVILLE COUNTY INC | Greenville | F30Z Mental Health & Crisis Intervention | $2.3M | 1 |
| CHESTER HEALTHCARE FOUNDATION | Chester | E129 Health Care | $2.3M | 0 |
| Habitat for Humanity for Georgetown County SC Inc | Georgetown | L20Z Housing & Shelter | $2.3M | 1 |
| WILDEWOOD COMMUNITY NEIGHBORHOOD INC | Columbia | — | $2.3M | 0 |
| SPRING ISLAND TRUST | Okatie | C30 Environment | $2.3M | 2 |
| CHARLESTON DIGITAL CORRIDOR FOUNDATION | Charleston | S41 Community Improvement & Capacity Building | $2.3M | 1 |
| GREENVILLE ARTS FESTIVAL | Greenville | A20 Arts, Culture & Humanities | $2.3M | 1 |
| THE MARTHA AND JOHN M RIVERS PERFORMANCE HALL FOUNDATION | Charleston | A12 Arts, Culture & Humanities | $2.3M | 1 |
| THE THERAPY PLACE INC | Columbia | O50 Youth Development | $2.3M | 1 |
| THE TUOMEY FOUNDATION | Sumter | E21I Health Care | $2.3M | 1 |
| INTERNATIONAL TRANSPORTATION INNOVATION CENTER | Greenville | S30 Community Improvement & Capacity Building | $2.2M | 3 |
| Penn Center Inc | St Helena Is | — | $2.2M | 2 |
| FAITH HOME INC | Greenwood | — | $2.2M | 1 |
| BLUFFTON-JASPER COUNTY VOLUNTEERS IN MEDICINE INC | Bluffton | E30 Health Care | $2.2M | 2 |
| CLARENDON HALL SCHOOL INC | Summerton | B24 Education | $2.2M | 0 |
| Keowee Key Utility Systems Inc | Salem | — | $2.2M | 0 |
| REBUILD UPSTATE | Greenville | X20 Religion-Related | $2.2M | 2 |
| WESTVIEW BEHAVIORAL HEALTH SERVICES | Newberry | — | $2.2M | 1 |
| CHARLESTON CHAMBER FOUNDATION | North Charleston | S114 Community Improvement & Capacity Building | $2.2M | 1 |
| AMERICAN FRIENDS OF ALUMOT OR SASA-SETTON AND CFJI INC | Charleston | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 0 |
| TOGETHER WOMEN RISE | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 1 |
| GREENVILLE AREA DEVELOPMENT CORPORATION | Greenville | S113 Community Improvement & Capacity Building | $2.2M | 4 |
| BOYS AND GIRLS CLUB OF THE GRAND STRAND INC | Myrtle Beach | O23 Youth Development | $2.2M | 1 |
| CHOSEN CHILDREN MINISTRIES INC | Inman | P31 Human Services | $2.2M | 1 |
| The Sinclair Foundation | Rock Hill | W99 Public & Societal Benefit | $2.2M | 0 |
| HABITAT FOR HUMANITY SPARTANBURG I | Spartanburg | L20Z Housing & Shelter | $2.2M | 1 |
| CHARLESTON COALITION FOR KIDS | Charleston | B99 Education | $2.2M | 1 |
| Homeless No More Inc | Columbia | L40 Housing & Shelter | $2.2M | 2 |
| Walhalla Civic Auditorium INC | Walhalla | S20 Community Improvement & Capacity Building | $2.2M | 1 |
| DORCHESTER COUNTY COMMUNITY OUTREACH | Summerville | L41 Housing & Shelter | $2.2M | 1 |
| CAMDEN COUNTRY CLUB | Camden | — | $2.2M | 0 |
| COMPETITIVE CHAMPIONS OF THE CAROLINAS | Fort Mill | N70 Recreation & Sports | $2.2M | 2 |
| PARTNERS FOR ACTIVE LIVING | Spartanburg | M40 Public Safety, Disaster Preparedness & Relief | $2.2M | 1 |
| UNIVERSITY CENTER FACILITIES CORPORATION III | Rock Hill | S19 Community Improvement & Capacity Building | $2.2M | 3 |
| OPERATION PATRIOTS FOB INC | Okatie | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 2 |
| CLARENDON FACILITIES CORPORATION | Manning | W20 Public & Societal Benefit | $2.1M | 0 |
| THE MONTESSORI SCHOOL OF CAMDEN | Camden | B29 Education | $2.1M | 1 |
| ARRHYTHMIA TECHNOLOGIES INSTITUTE INC | Greenville | — | $2.1M | 2 |
| EDUCATIONAL FACILITIES CORPORATION FOR LEXINGTON SCHOOL DISTRICT NO 2 | West Columbia | T990 Philanthropy, Voluntarism & Grantmaking Foundations | $2.1M | 3 |
| MEALS ON WHEELS INC | Anderson | — | $2.1M | 1 |
| FAIR PLAY CAMP SCHOOL INC | Westminster | F33Z Mental Health & Crisis Intervention | $2.1M | 1 |
