| Charleston Legal Access | North Charleston | I80 Crime & Legal-Related | $809k | 1 |
| Gullah Traveling Theater Inc | Beaufort | A65 Arts, Culture & Humanities | $808k | 2 |
| The Village Group | Georgetown | O20 Youth Development | $808k | 0 |
| LIGHTHOUSE MINISTRIES FLORENCE | Florence | P60Z Human Services | $807k | 0 |
| DEWEES UTILITY CORPORATION | Dewees Island | Y22 Mutual & Membership Benefit | $805k | 0 |
| RADIANT ACADEMY | Charleston | P33 Human Services | $805k | 0 |
| KENNEDYS S ASSISTIVE LIVING & EDUCATION | Columbia | P82 Human Services | $803k | 1 |
| AMERICAN WATER WORKS ASSOCIATION SOUTH CAROLINA SECTION | Lexington | W038 Public & Societal Benefit | $803k | 1 |
| KERSHAW AREA RESOURCE EXCHANGE | Kershaw | P60Z Human Services | $803k | 0 |
| ANY LENGTHS RECOVERY INC | Sumter | F20 Mental Health & Crisis Intervention | $802k | 0 |
| ALPHA GAMMA DELTA FRATERNITY THETA OMEGA CHAPTER | Columbia | — | $801k | 0 |
| IRONWORKERS JOINT APPRENTICESHIP IRONWORKERS LOCAL 848 | Charleston | — | $800k | 0 |
| SUMTER SPCA & HUMANE EDUCATION CENTER INC | Sumter | D200 Animal-Related | $800k | 4 |
| SIGNS 4 JESUS | Rock Hill | X20 Religion-Related | $800k | 0 |
| GREEN HEART PROJECT INC | Charleston | C42 Environment | $800k | 1 |
| Middle East Ministries | Fairforest | Q330 International, Foreign Affairs & National Security | $799k | 2 |
| LITTLEJOHN COMMUNITY CENTER INC | Clemson | S24Z Community Improvement & Capacity Building | $798k | 1 |
| LORD BERKELEY CONSERVATION TRUST | Moncks Corner | — | $798k | 1 |
| All About Change Inc | Greenville | P46 Human Services | $797k | 0 |
| BLACK PAGES INTERNATIONAL INC | Columbia | S31 Community Improvement & Capacity Building | $796k | 2 |
| MOUNTAIN VIEW CHRISTIAN ACADEMY | Cowpens | B20 Education | $796k | 0 |
| SOUTH CAROLINA ECONOMIC DEVELOPERS' ASSOCIATION | Charleston | — | $796k | 0 |
| NOAH'S ARKS RESCUE | Okatie | D20 Animal-Related | $795k | 0 |
| Boys & Girls Clubs of the Lakelands Region | Greenwood | O21 Youth Development | $795k | 1 |
| GROUND ZERO MINISTRIES INC | Myrtle Beach | O55 Youth Development | $795k | 1 |
| BARNWELL COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $794k | 0 |
| ACX BOOSTER CLUB OF CHARLESTON | Ladson | B11 Education | $794k | 0 |
| FLORENCE COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $794k | 1 |
| AREA 18 CUTTING HORSE ASSOC INC | Estill | — | $793k | 0 |
| THE HIVE COMMUNITY CIRCLE | Columbia | P80 Human Services | $793k | 5 |
| UPSTATE EMS COUNCIL INC | Greenville | — | $793k | 1 |
| The Childrens Council | Lancaster | — | $792k | 2 |
| CORE ACADEMY | Hopkins | K12 Food, Agriculture & Nutrition | $792k | 0 |
| LOCAL BOYS DO GOOD | Greenville | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $792k | 0 |
| ANDERSON COUNTY CONVENTION & VISITORS BUREAU | Anderson | S41 Community Improvement & Capacity Building | $788k | 1 |
| AMERICAN SHORE & BEACH PRESERVATION ASSOCIATION | Beaufort | C300 Environment | $788k | 0 |
| GREATER THAN US INC | Lyman | S12 Community Improvement & Capacity Building | $787k | 0 |
| COMMUNITY ASSISTANCE AND MENTORING PROGRAM | Hopkins | S20 Community Improvement & Capacity Building | $786k | 0 |
| Kappa Sigma Fraternity Housing Corp of Columbia | Columbia | — | $786k | 0 |
| EMPLOYERS NETWORK | Spartanburg | S31Z Community Improvement & Capacity Building | $786k | 1 |
| JUST SAY SOMETHING INC | Greenville | P400 Human Services | $785k | 1 |
| SPARTANBURG RECREATIONAL FACILITIES CORPORATION | Spartanburg | S20 Community Improvement & Capacity Building | $783k | 3 |
| GREENVILLE LITERACY ASSOCIATION | Greenville | B920 Education | $783k | 1 |
| AIKEN ASSOCIATION OF REALTORS | Aiken | Y03 Mutual & Membership Benefit | $781k | 0 |
| Arthur Bailey Ministries International | Fort Mill | X20 Religion-Related | $781k | 1 |
| WEXFORD FOUNDATION | Hilton Head Island | P99 Human Services | $781k | 0 |
| OSPREY VILLAGE INC | Hilton Head Island | L20 Housing & Shelter | $780k | 4 |
| Trinity Classical Academy of Summerville | Summerville | B20 Education | $779k | 4 |
| Lighthouse for Life | Irmo | — | $778k | 2 |
| CHAPMAN FOUNDATION INC | Greenville | B82 Education | $777k | 1 |
