| Sweet Repeat Charitable Foundation | Lake Wylie | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $547k | 0 |
| Tara Hall School Inc | Georgetown | P730 Human Services | $545k | 1 |
| HELPING HANDS NUTRITIONAL | Aiken | K30Z Food, Agriculture & Nutrition | $545k | 0 |
| MIDLAND VALLEY FIRE DEPARTMENT INC | Bath | M24 Public Safety, Disaster Preparedness & Relief | $544k | 0 |
| COASTLINE WOMENS CENTER | Conway | P40 Human Services | $544k | 2 |
| GREENVILLE URBAN LEAGUE SENIOR | Columbia | — | $544k | 0 |
| Womens South Carolina Golf Association | Blythewood | N6A Recreation & Sports | $544k | 1 |
| NAGRODSKY FAMILY FOUNDATION | Charleston | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $542k | 0 |
| THE SHEPHERDS FOLD INC | Rock Hill | — | $542k | 0 |
| VANTAGE POINT FOUNDATION | Charleston | — | $541k | 1 |
| UNITED WAY OF OCONEE COUNTY INC | Seneca | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $541k | 1 |
| Lowcountry Food Bank Endowment Fund | Charleston | K11 Food, Agriculture & Nutrition | $540k | 0 |
| SOUTH CAROLINA ALLIANCE OF YMCAS | Rock Hill | N12 Recreation & Sports | $540k | 0 |
| POCKETS FULL OF SUNSHINE | Hilton Head | J99 Employment | $540k | 2 |
| WOMEN IN UNITY | Edgefield | P40 Human Services | $539k | 0 |
| CHARLESTON ACADEMY OF MUSIC | Charleston | A68 Arts, Culture & Humanities | $539k | 1 |
| KEVIN & BRITTANY KISNER FOUNDATION | Aiken | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $539k | 0 |
| Palmetto Foundation for Prevention | Chapin | F20 Mental Health & Crisis Intervention | $539k | 2 |
| OUR DAILY REST INC | Seneca | L41 Housing & Shelter | $538k | 1 |
| LANCASTER SPCA | Lancaster | D20 Animal-Related | $538k | 0 |
| CHARLESTON COUNTY MEDICAL SOCIETY | Charleston | — | $537k | 2 |
| KAPPA DELTA SORORITY - BETA ZETA | Columbia | — | $537k | 0 |
| SOUTH CAROLINA WILDLIFE FEDERATION | Columbia | D013 Animal-Related | $537k | 1 |
| THE RESERVE AT LAKE KEOWEE CHARITABLE FO | Sunset | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $537k | 0 |
| OFFENSE DEFENSE EDUCATIONAL | Myrtle Beach | N116 Recreation & Sports | $535k | 0 |
| SOUTH CAROLINA ASSOCATION OF VETERINARIA | Columbia | — | $535k | 0 |
| MIRACLE ACADEMY NURSERY CENTER INC | Russellville | B20 Education | $535k | 0 |
| GREENVILLE SYMPHONY ENDOWMENT | Greenville | A118 Arts, Culture & Humanities | $535k | 0 |
| BETSY M CAMPBELL FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $535k | 1 |
| WEXFORD FOUNDATION | Hilton Head Island | P99 Human Services | $534k | 0 |
| CHIEFS ATHLETIC BOOSTER CLUB | Little River | B11 Education | $534k | 0 |
| ART LEAGUE OF HILTON HEAD INC | Hilton Head Island | — | $534k | 0 |
| BULLS SOCCER CLUB INC | Aiken | N60 Recreation & Sports | $534k | 0 |
| Aiken Polo Club Inc | Aiken | N6XZ Recreation & Sports | $533k | 0 |
| FORT LAWN COMMUNITY CENTER INC | Fort Lawn | W99 Public & Societal Benefit | $532k | 1 |
| DILLON HISTORIC SCHOOL FOUNDATION | Dillon | O99 Youth Development | $531k | 0 |
| THE BAILEY FOUNDATION | Clinton | — | $531k | 1 |
| PALMETTO ASSOCIATION FOR CHILDREN | Columbia | — | $530k | 1 |
| MUMTAZ FOUNDATION | Columbia | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $530k | 0 |
| SUMMERVILLE HIGH SCHOOL ATHLETIC CLUB | Summerville | B12 Education | $529k | 0 |
| Second Chance Emergency Placement Inc | Spartanburg | — | $528k | 1 |
| LEAN ENSEMBLE THEATER | Hilton Head Island | — | $527k | 1 |
| GREENVILLE CENTER FOR CREATIVE ARTS | Greenville | A25 Arts, Culture & Humanities | $526k | 1 |
| AMERICAN CIVIL LIBERTIES UNION | Columbia | — | $524k | 2 |
| DIANNES CALL | Columbia | E198 Health Care | $524k | 0 |
| JAMES E CLYBURN SCHOLARSHIP AND RESEARCH FOUNDATION | Columbia | B82Z Education | $523k | 1 |
| THE ANGEL OUTREACH | Catawba | P99 Human Services | $523k | 0 |
| PALMETTO BOYS STATE | Spartanburg | O50 Youth Development | $523k | 0 |
| BUFFALO VOLUNTEER FIRE DEPARTMENT | Blacksburg | — | $522k | 0 |
| THE ANIMAL MISSION | Columbia | D200 Animal-Related | $522k | 1 |
