| SOUTH CAROLINA MIDLANDS EMERGENCY MEDICAL SERVICE MANAGEMENT ASSOCIAT | West Columbia | — | $607k | 0 |
| FULLER NORMAL AND INDUSTRIAL INSTITUTE | Greenville | — | $607k | 4 |
| KEVIN & BRITTANY KISNER FOUNDATION | Aiken | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $607k | 0 |
| OCONEE ECONOMIC ALLIANCE | Seneca | S41 Community Improvement & Capacity Building | $607k | 0 |
| LOWCOUNTRY HOCKEY ASSOCIATION DBA CHARLESTON YOUTH HOCKEY ASSOC | North Charleston | N68 Recreation & Sports | $607k | 4 |
| SIGMA ALPHA EPSILON FRATERNITY | Columbia | N50 Recreation & Sports | $606k | 0 |
| Habitat For Humanity International Inc | Wando | — | $605k | 2 |
| FRIENDS OF FISHER HOUSE CHARLESTON | Charleston | E86 Health Care | $605k | 0 |
| PRISMA HEALTH BAPTIST EASLEY FOUNDATION | Easley | E22I Health Care | $604k | 1 |
| GOWER ESTATES POOL INC | Greenville | — | $603k | 0 |
| FRIENDS OF COASTAL SOUTH CAROLINA | Mt Pleasant | C60 Environment | $603k | 0 |
| GirlUp GVL | Greenville | O22 Youth Development | $603k | 1 |
| LOWCOUNTRY CHRISTIAN COMMUNITY SCHOOL | Daniel Island | B200 Education | $603k | 0 |
| FOOD FOR THE SOUL-KERSHAW COUNTY INC | Camden | B90 Education | $603k | 1 |
| PALMETTO BOYS STATE C/O BRAND R STILLE | Spartanburg | O50 Youth Development | $602k | 0 |
| BELVEDERE EARLY LEARNING CENTER INC | Columbia | — | $602k | 2 |
| SOUTH CAROLINA FREE CLINIC ASSOC | Union | E60 Health Care | $601k | 0 |
| Institute for Strategic and Equitable Development | Charleston | S30 Community Improvement & Capacity Building | $600k | 1 |
| Life Unplugged | Hardeeville | O50 Youth Development | $600k | 2 |
| CHATTOOGA CONSERVANCY | Mountain Rest | C30 Environment | $599k | 1 |
| Jewish Family Services of Greater Charleston Inc | Charleston | P50 Human Services | $599k | 1 |
| CORNERSTONE CHRISTIAN SCHOOL | Camden | B20 Education | $599k | 0 |
| THE DANIEL O MORRIS SOUTH CAROLINA LOW COUNTRY HERITAGE TRUST | Hilton Head Island | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $599k | 1 |
| DELTA CHAPTER ALUMNI HOUSE CORPORATION | Columbia | B83 Education | $599k | 0 |
| Bleeding Disorders Association of South Carolina | Greenville | L99 Housing & Shelter | $597k | 1 |
| Alliance for a Healthier South Carolina | Columbia | — | $596k | 3 |
| BETTY & JAMES K STONE FOUNDATION | Wellford | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $594k | 1 |
| CULTURAL ARTS FOUNDATION FOUNTAIN INN | Fountain Inn | A61 Arts, Culture & Humanities | $594k | 0 |
| UPPER STATE APARTMENT ASSOCIATION | Greenville | — | $594k | 1 |
| JASPER ANIMAL RESCUE MISSION | Ridgeland | D20 Animal-Related | $593k | 1 |
| NATHANS FRIENDS | Johns Island | P20 Human Services | $593k | 0 |
| FOOTLIGHT PLAYERS INC | Charleston | A650 Arts, Culture & Humanities | $592k | 0 |
| INDEPENDENT BANKS OF SOUTH CAROLINA | Chapin | — | $592k | 0 |
| 836 INC | Myrtle Beach | P80 Human Services | $591k | 0 |
| I58 INC | Chester | L40 Housing & Shelter | $590k | 1 |
| FIX HORRY ROADS | Myrtle Beach | W01 Public & Societal Benefit | $589k | 0 |
| DAYBREAK INC | Columbia | R62Z Civil Rights, Social Action & Advocacy | $588k | 2 |
| Columbia City Jazz Company | Columbia | A680 Arts, Culture & Humanities | $588k | 4 |
| MATTHEW2540 | Greenwood | X20 Religion-Related | $588k | 0 |
| PICKENS COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $587k | 1 |
| GREAT OAK EQUINE ASSISTED PROGRAMS | Aiken | P80 Human Services | $587k | 0 |
| TRIDENT LITERACY ASSOCIATION INC | North Charleston | — | $586k | 1 |
| NATIONAL SOCIETY OF THE COLONIAL DAMES OF AMERICA IN THE STATE OF SC | Charleston | A800 Arts, Culture & Humanities | $586k | 0 |
| SHARED SERVICES ALLIANCE | Greenville | F33 Mental Health & Crisis Intervention | $586k | 1 |
| EDGEFIELD COUNTY YOUTH EMPOWERMENT CENTER | Johnson | O50 Youth Development | $586k | 0 |
| BELINA LEE LAZZAR TRUST 31973785 | Fort Mill | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $585k | 1 |
| Clinical Biotechnology Research Institute at RSFH | Charleston | H99 Medical Research | $585k | 18 |
| The ARK of SC | Summerville | G83 Diseases, Disorders & Medical Disciplines | $585k | 0 |
| PLEASANT VALLEY CONNECTION | Greenville | P28 Human Services | $584k | 1 |
| CONFEDERATE HOME AND COLLEGE | Charleston | L410 Housing & Shelter | $583k | 0 |
