| JOHN WINTHROP CHARITABLE TRUST | Charleston | — | $325k | 0 |
| ROBERTA B SENN FOUNDATION | Spartanburg | X90 Religion-Related | $325k | 1 |
| DAD TIRED | Blufton | P46 Human Services | $324k | 1 |
| WACCAMAW HIGH SCHOOL ATHLETIC BOOSTER CLUB | Pawleys Island | N41Z Recreation & Sports | $323k | 0 |
| Save Our Saluda | Marietta | C32 Environment | $323k | 1 |
| KINGSTREE LODGE NO 1886 LOYAL ORDER OF MOOSE | Kingstree | — | $323k | 0 |
| Focused Living Ministries | Columbia | X21 Religion-Related | $323k | 4 |
| HILTON HEAD ISLAND SWIM TEAM | Hilton Head Island | — | $322k | 1 |
| BOOST BY HINGE | Greenville | P20 Human Services | $322k | 0 |
| South Carolina Association for | Columbia | — | $322k | 0 |
| MYRTLE BEACH HIGH SCHOOL ALL SPORTS | Myrtle Beach | B112 Education | $322k | 0 |
| KNOW2 | Gaffney | O50 Youth Development | $321k | 2 |
| TEACHING-FAMILY ASSOCIATION | Anderson | — | $321k | 0 |
| WWWPILOTSNPAWSORG INC | Landrum | D20 Animal-Related | $321k | 1 |
| CHARLES E HARWOOD TRUST | Bluffton | — | $321k | 2 |
| MARLBORO COUNTY COUNCIL ON AGING | Bennettsville | P81Z Human Services | $321k | 1 |
| Hilton Head Island All Sports | Hilton Head | B11 Education | $320k | 1 |
| CAROLINA HONDURAS HEALTH FOUNDATION | Conway | E30 Health Care | $319k | 0 |
| GREATER GREENVILLE SCOTTISH | Greenville | N32 Recreation & Sports | $319k | 0 |
| GirlUp GVL | Greenville | O22 Youth Development | $319k | 1 |
| WE3 MISSIONS INC | Boiling Springs | P99 Human Services | $319k | 0 |
| DISTRICT ALPHA OF THE CLEMSON | Clemson | B84 Education | $319k | 1 |
| BLUFFTON RUSH FOUNDATION LLC | Bluffton | N12 Recreation & Sports | $318k | 1 |
| DANIEL-EDWARDS BAND BOOSTERS | Central | B122 Education | $318k | 0 |
| Students in the Word Inc | Pawleys Island | X20 Religion-Related | $318k | 1 |
| GREENWOOD AREA CHAMBER OF COMMERCE | Greenwood | — | $317k | 1 |
| NATIONAL STEEPLECHASE MUSEUM INC | Camden | A50 Arts, Culture & Humanities | $317k | 0 |
| THE FOUR BEES FOUNDATION | Greenville | — | $317k | 0 |
| MID-CAROLINA ELECTRIC TRUST INC | Lexington | T21Z Philanthropy, Voluntarism & Grantmaking Foundations | $316k | 0 |
| FAIR HAVEN HOME FOR MEN INC | Saint Stephen | L20 Housing & Shelter | $316k | 0 |
| LOW COUNTRY VOLLEYBALL CLUB | Bluffton | N60 Recreation & Sports | $315k | 4 |
| BURTON CENTER FOUNDATION | Greenwood | — | $315k | 0 |
| GOOD SAMARITAN MEDICAL CLINIC INC | Chester | P20 Human Services | $315k | 1 |
| AMERICAN POSTAL WORKERS UNION | Columbia | — | $315k | 9 |
| RIDEABILITY THERAPEUTIC RIDING CENTER INC | Clover | P80 Human Services | $315k | 1 |
| THE WLT FOUNDATION | Greenville | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $314k | 0 |
| YOUTHBASE INC | Greenville | O50 Youth Development | $314k | 1 |
| SEA TURTLE PATROL HILTON HEAD | Hilton Head | — | $314k | 2 |
| United Way of Greater Hartsville | Hartsville | — | $314k | 1 |
| MEALS ON WHEELS OF SUMMERVILLE INC | Summerville | K36Z Food, Agriculture & Nutrition | $314k | 0 |
| FOUNDATION FOR SPIRITUALITY AND THE | Charleston | A99 Arts, Culture & Humanities | $314k | 2 |
| THE SUSAN MORROW LEGACY FOUNDATION | Okatie | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $313k | 0 |
| THE ANIMAL ADVOCATES | Barnwell | D11 Animal-Related | $313k | 0 |
| SOUTH CAROLINA LAW ENFORCEMENT | Columbia | — | $312k | 0 |
| WINYAH RIVERS FOUNDATION INC | Conway | C30 Environment | $312k | 0 |
| GREENVILLE CIVIC CHORALE | Greenville | — | $312k | 1 |
| CANTERBURY COUNSELING CENTER | Greenville | F32 Mental Health & Crisis Intervention | $312k | 1 |
| IOSH USA CHAPTER - SOUTHEAST PRIORY INC | Charleston | N50 Recreation & Sports | $312k | 0 |
| LEO SANTA | Greenville | P58 Human Services | $312k | 0 |
| THE HERITAGE LIBRARY FOUNDATION INC | Hilton Head Island | B70 Education | $311k | 1 |
