| CHRISTIAN COALITION | Charleston | — | $349k | 1 |
| Greater Hartsville Chamber of Commerce | Hartsville | — | $348k | 0 |
| NEIGHBORHOOD FOCUS | Greenville | P20 Human Services | $348k | 1 |
| CAINHOY ATHLETIC SOCCER CLUB | Charleston | N64 Recreation & Sports | $348k | 0 |
| OSPREY VILLAGE THRIFT STORES LLC | Hilton Head Island | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $348k | 1 |
| HISTORIC PARADISE FOUNDATION NFP | Fort Mill | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $348k | 3 |
| COMMUNITY KITCHEN INC OF MYRTLE BEACH | Myrtle Beach | K31Z Food, Agriculture & Nutrition | $347k | 0 |
| SIDEWALK HOPE INC | Spartanburg | O50 Youth Development | $347k | 0 |
| HELPING FLORENCE FLOURISH | Florence | S80 Community Improvement & Capacity Building | $347k | 0 |
| LOCAL 470 APPRENTICESHIP FUND | Graniteville | J22 Employment | $346k | 1 |
| REMNANT HOUSE OUTREACH MINISTRY INC | Moncks Corner | X20 Religion-Related | $346k | 1 |
| Coastal Crisis Chaplaincy | Charleston | S80Z Community Improvement & Capacity Building | $346k | 0 |
| University of South Carolina Theta Chi Fraternity | Columbia | — | $345k | 0 |
| HARVEST FREE MEDICAL CLINIC | North Charleston | E30 Health Care | $345k | 2 |
| SOUTH CAROLINA HIGH SCHOOL RODEO ASSOCIATION | Anderson | N70 Recreation & Sports | $344k | 0 |
| Columbia Parks & Recreation Foundation | Columbia | N32 Recreation & Sports | $344k | 0 |
| THE AIKEN CORPORATION OF SOUTH CAROLINA | Aiken | A65 Arts, Culture & Humanities | $344k | 0 |
| SC Women's Leadership Network | Columbia | W70 Public & Societal Benefit | $344k | 0 |
| CATAWBA AREA COALITION FOR THE HOMELESS | Rock Hill | L01 Housing & Shelter | $344k | 1 |
| SAINT HELENA ISLAND GULLAH COMMUNITY HOUSING PROJECT | Okatie | L80 Housing & Shelter | $344k | 0 |
| ALLIANCE FOR FULL ACCEPTANCE | Charleston | R26 Civil Rights, Social Action & Advocacy | $343k | 2 |
| JOHN A WHITE FAMILY FOUNDATION INC | Hilton Head | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $343k | 0 |
| BEAUFORT WOMENS CENTER | Beaufort | — | $343k | 1 |
| SUZERAIN | Lexington | P80 Human Services | $342k | 1 |
| THE FOUR BEES FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $342k | 0 |
| GREENWOOD COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | — | $341k | 1 |
| HISTORIC BLUFFTON FOUNDATION | Bluffton | — | $341k | 0 |
| 721 MINISTRIES INC | Columbia | X03 Religion-Related | $340k | 1 |
| MERE CHRISTIANITY FORUM INC | Travelers Rest | X20 Religion-Related | $340k | 0 |
| Brown Family Ministries Inc | Travelers Rest | X20 Religion-Related | $340k | 2 |
| WILBUR S SMITH AND SALLY J SMITH FOUNDATION INC | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $340k | 0 |
| The Laura E DuPont Foundation | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $339k | 0 |
| TEACHERS SUPPLY CLOSET | Charleston | P58 Human Services | $339k | 1 |
| SOAR Special Recreation of the Lowcountr | Hilton Head Island | N72 Recreation & Sports | $338k | 1 |
| SCOTTISH RITE ORIENT | Columbia | Y40Z Mutual & Membership Benefit | $338k | 0 |
| THE OUTSIDE FOUNDATION | Hilton Head Island | C60 Environment | $338k | 1 |
| BEAUFORT AREA HOSPITALITY ASSOCIATION INC | Beaufort | S41 Community Improvement & Capacity Building | $338k | 0 |
| GIRLS ON THE RUN TRI COUNTY SC | Rock Hill | O50 Youth Development | $338k | 1 |
| SCOTTISH RITE BODIES IN THE VALLEY OF SPARTANBURG | Spartanburg | — | $337k | 0 |
| SRS HERITAGE FOUNDATION INC | Aiken | A80 Arts, Culture & Humanities | $337k | 1 |
| Clemson Paw Partners | Clemson | D20 Animal-Related | $337k | 0 |
| CHI OMEGA FRATERNITY-PSI KAPPA CHAP | Clemson | — | $337k | 0 |
| THE MASTERS MISSIONS INC | North Myrtle Beach | Q330 International, Foreign Affairs & National Security | $336k | 1 |
| NORTH MYRTLE BEACH RESCUE SQUAD INC | North Myrtle Beach | — | $336k | 1 |
| HARRY H GIBSON FAMILY FOUNDATION | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $336k | 0 |
| CHRISTIAN REVIVAL CHURCH ASSOCIATION | Greenville | X20 Religion-Related | $336k | 0 |
| HILINSKI'S HOPE INC | Irmo | F99 Mental Health & Crisis Intervention | $335k | 0 |
| SEA ISLAND YACHT CLUB | Wadmalaw Island | N50 Recreation & Sports | $335k | 0 |
| PALMETTO INNOVASPHERE INC | Piedmont | U03 Science & Technology | $335k | 2 |
| GULLAH FESTIVAL OF SOUTH CAROLINA | Beaufort | A99 Arts, Culture & Humanities | $334k | 0 |
