| SECOND BAPTIST COMMUNITY | Aiken | P20 Human Services | $219k | 2 |
| NAMI LOWCOUNTRY | Hilton Head Island | F30Z Mental Health & Crisis Intervention | $219k | 1 |
| Greenville Country Club Scholarship Foundation | Greenville | B82 Education | $219k | 0 |
| THE BOWMAN LOW RENTAL HOUSING INC | Columbia | L20 Housing & Shelter | $219k | 0 |
| PMP COMMUNITY PARK INC | Greenville | — | $219k | 0 |
| ISLAND CLUB TENNIS CLUB | Hilton Head Island | — | $218k | 0 |
| 701 Center for Contemporary Art | Columbia | A20 Arts, Culture & Humanities | $218k | 0 |
| YOUTH CORPS | Columbia | O53 Youth Development | $218k | 2 |
| Palmetto City Ballet | Mt Pleasant | A63 Arts, Culture & Humanities | $218k | 2 |
| DREHER HIGH SCHOOL ATHLETIC | Columbia | — | $218k | 0 |
| TRANQUILIDAD FOUNDATION | Aiken | Q33 International, Foreign Affairs & National Security | $218k | 0 |
| HILTON HEAD CHORAL SOCIETY INC | Hilton Head Island | — | $217k | 1 |
| THE GREEN WAVE ATHLETIC BOOSTER | Easley | B12 Education | $217k | 0 |
| Sigma Chi Fraternity Gamma Nu Chapter | Columbia | — | $217k | 0 |
| ROTARY CLUB OF FIVE POINTS | Columbia | — | $217k | 0 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B012 Education | $217k | 0 |
| BLUFFTON HIGH SCHOOL ALL SPORTS BOOSTER | Bluffton | B112 Education | $217k | 0 |
| THE WILLIAM FOSS II MEMORIAL FOUNDATION | Aiken | — | $217k | 0 |
| The Creek at Mungo Park | Columbia | — | $217k | 0 |
| Timothy J Tuomey Trust | Sumter | — | $216k | 3 |
| JAPAN AMERICA ASSOCIATION OF SOUTH CAROLINA | Greenville | Q200 International, Foreign Affairs & National Security | $216k | 0 |
| HONOR HEALTH CAREER PROGRAMS | Greenville | — | $216k | 1 |
| KENNETH & JOAN L CAMPBELL FOUNDATION | Hilton Head Island | — | $216k | 0 |
| KAPPA ALPHA ORDER | Clemson | — | $215k | 0 |
| WOMEN'S ASSOCIATION OF HILTON HEAD | Hilton Head Island | — | $215k | 0 |
| MICHAEL & LOUISE LYNCH CHARITABLE | Hilton Head Island | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $215k | 0 |
| CANCER THRIFT STORE OF BEAUFORT | Beaufort | W99 Public & Societal Benefit | $215k | 0 |
| INTERNATIONAL PLANT PROPAGATORS' | Columbia | — | $215k | 3 |
| Preservation Trust for Historic | Beaufort | X11 Religion-Related | $215k | 0 |
| STAND AT THE CROSSROADS MINISTRIES | Aiken | L40 Housing & Shelter | $215k | 1 |
| GREATER COLUMBIA COMMUNITY RELATIONS | Columbia | — | $215k | 1 |
| CANAL APARTMENTS INC | Bluffton | P32 Human Services | $214k | 0 |
| FAM-REC INC | Spartanburg | — | $214k | 0 |
| PDMH Board Foundation | Florence | F11 Mental Health & Crisis Intervention | $214k | 0 |
| LOWCOUNTRY MARINE MAMMAL NETWORK | North Charleston | D30 Animal-Related | $214k | 1 |
| THE LATTA SCHOOLS EDUCATIONAL FOUNDATION INC | Latta | B82 Education | $214k | 0 |
| South Carolina Association of Criminal | Columbia | — | $214k | 1 |
| ROTARY CLUB OF HILTON HEAD ISLAND | Hilton Head Island | — | $214k | 0 |
| MINISTERIO LOGOS Y RHEMA DE DIOS CORP | North Augusta | X20 Religion-Related | $214k | 0 |
| LEXINGTON COUNTY FARM BUREAU | Lexington | — | $213k | 0 |
| SOUTH CAROLINA CROP IMPROVEMENT ASSOC | Clemson | — | $213k | 0 |
| South Carolina Native Plant Society | Conway | B80 Education | $213k | 0 |
| Richland County Bar Association | Columbia | — | $213k | 0 |
| GREENVILLE SOCIETY FOR HUMAN | Greenville | S41 Community Improvement & Capacity Building | $213k | 0 |
| HELP FOR LANDOWNERS | Conway | C34 Environment | $212k | 0 |
| Messler Family Foundation | Charleston | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $212k | 0 |
| MT PLEASANT ACADEMY PTA | Mt Pleasant | — | $212k | 0 |
| 2R3 TREASURE HOUSE | Beaufort | P29 Human Services | $212k | 0 |
| DISCOVERY THERAPIES INC | Columbia | B90 Education | $212k | 1 |
| First United Methodist Church | Marion | P330 Human Services | $212k | 1 |
