| RED CLOUD RENEWABLE | Pine Ridge | C35 Environment | $2.8M | 4 |
| Denny Sanford Foundation | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 0 |
| SACRED HEART CENTER | Eagle Butte | P43Z Human Services | $2.8M | 1 |
| BLACK HILLS WORKS FOUNDATION INC | Rapid City | J00I Employment | $2.7M | 0 |
| MCCROSSAN FOUNDATION INC | Sioux Falls | — | $2.7M | 0 |
| HABITAT FOR HUMANITY | Sioux Falls | — | $2.7M | 1 |
| SIOUX EMPIRE FAIR ASSOCIATION INC | Sioux Falls | N52 Recreation & Sports | $2.7M | 1 |
| AsOne Ministries | Sioux Falls | P60 Human Services | $2.7M | 1 |
| LUTHERAN SOCIAL SERVICES OF SD | Sioux Falls | — | $2.7M | 2 |
| DAKOTA BIOWORX | Brookings | S30 Community Improvement & Capacity Building | $2.6M | 0 |
| SOUTHERN PLAINS BEHAVIORAL | Winner | — | $2.6M | 2 |
| LINCOLN CNTY RURAL WATER SYSTEM INC | Sioux Falls | — | $2.6M | 8 |
| ONEHEART | Rapid City | L41 Housing & Shelter | $2.5M | 2 |
| WATERTOWN AREA COMMUNITY FOUNDATION | Watertown | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 0 |
| WILMOT CARE CENTER | Wilmot | E91 Health Care | $2.5M | 1 |
| Edwards Family Foundation | Aberdeen | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 0 |
| SICANGU OWAYAWA OTI | Mission | B90 Education | $2.5M | 8 |
| LIVE CENTER INC | Lemmon | — | $2.5M | 2 |
| South Eastern Development Foundation | Sioux Falls | S32 Community Improvement & Capacity Building | $2.4M | 0 |
| Area IV Senior Citizens Planning Council | Aberdeen | P810 Human Services | $2.4M | 2 |
| WORKING AGAINST VIOLENCE INC | Rapid City | — | $2.4M | 2 |
| St Francis Mission | St Francis | X220 Religion-Related | $2.4M | 2 |
| ABBOTT HOUSE FOUNDATION INC | Mitchell | P34J Human Services | $2.4M | 0 |
| SOUTH DAKOTA HISTORICAL SOCIETY | Pierre | A80 Arts, Culture & Humanities | $2.4M | 1 |
| NATIONAL MUSIC MUSEUM | Vermillion | A540 Arts, Culture & Humanities | $2.4M | 0 |
| UNITED WAY OF THE BLACK HILLS | Rapid City | T00J Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 2 |
| Community Indoor Tennis Center | Sioux Falls | N66 Recreation & Sports | $2.3M | 1 |
| RURAL ELECTRIC ECONOMIC DEVELOPMENT INC | Madison | S32 Community Improvement & Capacity Building | $2.3M | 0 |
| INTERNATIONAL BROTHERHOOD OF | Sioux Falls | — | $2.3M | 5 |
| DONNA M RASMUSSEN IRREV TR FBO DOW RUMMEL | Sioux Falls | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 1 |
| DONNA M RASMUSSEN IRREV TR FBO ZION LUTHERAN | Sioux Falls | Z99 Unknown | $2.2M | 1 |
| INSTITUTE OF THE RANGE & THE | Hot Springs | D340 Animal-Related | $2.2M | 1 |
| ASSOCIATED SCHOOL BOARDS OF | Pierre | — | $2.2M | 20 |
| SOUTH DAKOTA RETAILERS ASSOCIATION | Pierre | — | $2.2M | 1 |
| MARGARET CHRISTOPHERSON CHARITABLE TR | Sioux Falls | — | $2.2M | 1 |
| ATM INDUSTRY ASSOCIATION | Sioux Falls | S41 Community Improvement & Capacity Building | $2.2M | 6 |
| CHILDREN'S MUSEUM OF SOUTH DAKOTA | Brookings | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 1 |
| COLLISION MINISTRIES INC | Sioux Falls | O50 Youth Development | $2.2M | 0 |
| COMPASSION CHILD CARE | Sioux Falls | P3 Human Services | $2.2M | 0 |
| OYATE TECA PROJECT INC | Kyle | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 1 |
| JOHN D & EDNA HOFER TRUST | Mitchell | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 1 |
| BOYS AND GIRLS CLUB OF THE CAPITAL AREA | Pierre | O23 Youth Development | $2.2M | 1 |
| SOUTH DAKOTA PARKS AND WILDLIFE | Pierre | — | $2.1M | 1 |
| SOUTH DAKOTA BLACK HILLS BADLANDS | Rapid City | — | $2.1M | 1 |
| MISSION HAITI | Sioux Falls | X99 Religion-Related | $2.1M | 2 |
| MAZASKA OWECASO OTIPI FINANCIAL INC | Pine Ridge | L82 Housing & Shelter | $2.1M | 5 |
| ADDICTION RECOVERY CENTERS | Rapid City | F22Z Mental Health & Crisis Intervention | $2.1M | 1 |
| Monument Health Inc | Rapid City | E21 Health Care | $2.1M | 7 |
| THE LOST AND FOUND ASSOCIATION | Sioux Falls | F40 Mental Health & Crisis Intervention | $2.1M | 1 |
| MOCCASIN CREEK COUNTRY CLUB | Aberdeen | — | $2.1M | 0 |
