| SOUTH CENTRAL CHILD DEVELOPMENT INC | Wagner | — | $3.7M | 2 |
| TEKAKWITHA NURSING CENTER | Sisseton | — | $3.7M | 3 |
| WESKOTA MANOR INC | Wessington Springs | E910 Health Care | $3.7M | 1 |
| NE SOUTH DAKOTA COMMUNITY ACTION PROGRAM INC | Sisseton | — | $3.7M | 5 |
| SOUTH DAKOTA ASSOCIATION OF RURAL WATER SYSTEMS | Madison | — | $3.6M | 2 |
| LEMMON AREA MEDICAL ASSOCIATION | Lemmon | E22 Health Care | $3.6M | 1 |
| Community Transit of Watertown Sisseton Inc | Watertown | W40 Public & Societal Benefit | $3.6M | 2 |
| NORTHEAST SOUTH DAKOTA HEAD START PROGRAM INC | Aberdeen | — | $3.6M | 2 |
| SOUTH DAKOTA RURAL ELECTRIC ASSOCIATION | Pierre | — | $3.6M | 36 |
| THE HURON CLINIC FOUNDATION LTD | Huron | E110 Health Care | $3.6M | 5 |
| EASTERN STAR HOME OF SOUTH DAKOTA INCORPORATED | Redfield | — | $3.6M | 1 |
| SOUTH DAKOTA BEEF INDUSTRY COUNCIL INC | Pierre | — | $3.6M | 1 |
| LARSON FOUNDATION | Sioux Falls | — | $3.5M | 1 |
| VISIT RAPID CITY | Rapid City | S41 Community Improvement & Capacity Building | $3.5M | 1 |
| ICE SPORTS ASSOCIATION DBA SCHEELS ICEPLEX | Sioux Falls | O20 Youth Development | $3.5M | 1 |
| SOUTH DAKOTA FARM BUREAU FEDERATION | Huron | — | $3.4M | 2 |
| DOUGLAS ELECTRIC COOPERATIVE INC | Armour | — | $3.4M | 6 |
| OAHE CHILD DEVELOPMENT CENTER INC | Pierre | B22Z Education | $3.3M | 2 |
| HANSON FAMILY FOUNDATION FOR THE WELL-BEING OF GOD'S CREATURES | Sioux Falls | D20 Animal-Related | $3.3M | 0 |
| WESTERN SOUTH DAKOTA SENIOR SERVICES INC | Rapid City | — | $3.3M | 2 |
| KADOKA NURSING HOME ASSOCIATION | Kadoka | E91Z Health Care | $3.3M | 4 |
| DELTA DENTAL OF SOUTH DAKOTA FOUNDATION | Pierre | E34K Health Care | $3.3M | 2 |
| SOUTH DAKOTA PARTNERS IN EDUCATION | Sioux Falls | B82 Education | $3.3M | 1 |
| Mni Waste' Water Company | Eagle Butte | Y11 Mutual & Membership Benefit | $3.3M | 8 |
| SUNNYCREST VILLAGE INC | Sioux Falls | L22Z Housing & Shelter | $3.3M | 2 |
| BROOKINGS HEALTH SYSTEM INVESTMENT AUTHORITY | Brookings | E60 Health Care | $3.3M | 2 |
| CHEYENNE RIVER YOUTH PROJECT INC | Eagle Butte | O50 Youth Development | $3.2M | 1 |
| CH ROBINSON WORLDWIDE FOUNDATION | Sioux Falls | B82 Education | $3.2M | 0 |
| DIAMOND WILLOW MINISTRIES | Fort Thompson | P60 Human Services | $3.2M | 0 |
| CALL TO FREEDOM | Sioux Falls | P62 Human Services | $3.2M | 2 |
| LUTHERANS OUTDOORS IN SOUTH DAKOTA INC | Sioux Falls | — | $3.2M | 0 |
| BEAR BUTTE VALLEY WATER INC | Sturgis | K20 Food, Agriculture & Nutrition | $3.1M | 0 |
| BROOKINGS AREA UNITED WAY | Brookings | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $3.1M | 0 |
| BRANCHES FOUNDATION | Sioux Falls | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.1M | 0 |
| SD ASSOCIATION OF HEALTHCARE ORGANIZATIONS | Sioux Falls | — | $3.1M | 4 |
| AURORA-BRULE RURAL WATER SYSTEM | Kimball | — | $3M | 6 |
| PONDEROSA APARTMENTS INC | Spearfish | L21 Housing & Shelter | $3M | 0 |
| DAKOTA PLAINS LEGAL SERVICES | Mission | — | $3M | 3 |
| MOUNT RUSHMORE NATIONAL MEMORIAL SOCIETY | Rapid City | — | $3M | 2 |
| MENNO-OLIVET CARE CENTER INC | Menno | P750 Human Services | $3M | 1 |
| VERMILLION AREA CHAMBER OF COMMERCE AND DEVELOPMENT COMPANY | Vermillion | — | $3M | 0 |
| VIA-BRADLEY COLLEGE OF ENGINEERING FOUND C/O FIRST PREMIER BANK TRUST DEPARTMENT | Sioux Falls | B120 Education | $3M | 0 |
| WAKONDA HERITAGE MANOR | Wakonda | P750 Human Services | $3M | 1 |
| FARMERS EDUCATIONAL & COOPERATIVE UNION | Huron | — | $2.9M | 2 |
| MAKE-A-WISH FOUNDATION OF SOUTH DAKOTA & MONTANA | Sioux Falls | — | $2.9M | 3 |
| SOUTH DAKOTA NETWORK AGAINST FAMILY VIOLENCE AND SEXUAL ASSAULT INC | Sioux Falls | — | $2.9M | 1 |
| ST FRANCIS HOUSE OF SIOUX FALLS | Sioux Falls | — | $2.8M | 1 |
| SPECIAL OLYMPICS SOUTH DAKOTA INC | Sioux Falls | N72Z Recreation & Sports | $2.8M | 0 |
| SOUTH DAKOTA EDUCATION ASSOCIATION | Pierre | — | $2.8M | 4 |
| Strand-Kjorsvig Community Rest Home | Roslyn | E91Z Health Care | $2.8M | 0 |
