| NATIVE CDFI NETWORK INC | Rapid City | S30 Community Improvement & Capacity Building | $1.7M | 1 |
| INSTITUTE OF LUTHERAN THEOLOGY | Brookings | X20 Religion-Related | $1.7M | 2 |
| Tanka Fund | Rapid City | D30 Animal-Related | $1.7M | 4 |
| SOUTH DAKOTA STATE MEDICAL | Sioux Falls | — | $1.7M | 3 |
| CHRISTIAN CENTER EDUCATIONAL SERVICES | Sioux Falls | B21 Education | $1.7M | 0 |
| KARL & MARY JO WEGNER HEALTH SCIENCES | Sioux Falls | P20 Human Services | $1.7M | 0 |
| PEOPLE'S TRANSIT | Huron | P52 Human Services | $1.7M | 1 |
| Black Hills Center for American Indian | Rapid City | E052 Health Care | $1.6M | 2 |
| LUTHER HOUSE OF STUDY | Sioux Falls | B60 Education | $1.6M | 2 |
| ALPHA CENTER | Sioux Falls | R62Z Civil Rights, Social Action & Advocacy | $1.6M | 0 |
| FACE IT TOGETHER INC | Sioux Falls | F99 Mental Health & Crisis Intervention | $1.6M | 2 |
| NORTHERN HILLS ALCOHOL AND DRUG INF | Sturgis | — | $1.6M | 0 |
| Boys and Girls Club of Watertown | Watertown | O23Z Youth Development | $1.6M | 1 |
| HANSON RURAL WATER SYSTEM | Emery | — | $1.6M | 7 |
| SOUTH DAKOTA MUNICIPAL LEAGUE | Ft Pierre | — | $1.6M | 3 |
| HOT SPRINGS AMBGULANCE SERVICE | Hot Springs | M41 Public Safety, Disaster Preparedness & Relief | $1.6M | 6 |
| Opus Prize Foundation | Sioux Falls | — | $1.5M | 3 |
| SIOUX YMCA | Dupree | P27 Human Services | $1.5M | 1 |
| BLYTHE BRENDEN-MANN FOUNDATION | Sioux Falls | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $1.5M | 1 |
| MITCHELL HOSPICE HOUSE | Jefferson | P74 Human Services | $1.5M | 0 |
| LOWER BRULE COMMUNITY COLLEGE INC | Lower Brule | B99Z Education | $1.5M | 1 |
| REALTOR ASSOCIATION OF THE SIOUX EMPIRE | Sioux Falls | — | $1.5M | 1 |
| THE CASSINI TRUST FGA PRIVATE TRUST COMPANY LLC AS TRUSTEE | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $1.5M | 1 |
| ABERDEEN AREA HUMANE SOCIETY | Aberdeen | D200 Animal-Related | $1.5M | 0 |
| LIFELIGHT COMMUNICATIONS INC | Sioux Falls | X99 Religion-Related | $1.5M | 2 |
| SALT OF THE EARTH FOUNDATION | Sioux Falls | A33Z Arts, Culture & Humanities | $1.5M | 0 |
| FAMILY SERVICE INC | Sioux Falls | — | $1.5M | 1 |
| MITCHELL AREA CHAMBER OF COMMERCE | Mitchell | — | $1.5M | 3 |
| Deadwood Area Chamber & Visitor's Bureau | Deadwood | — | $1.5M | 2 |
| ADULT DAY CENTER OF THE BLACK HILLS | Rapid City | — | $1.5M | 1 |
| Yankton Transit Inc | Yankton | Z99 Unknown | $1.5M | 0 |
| UNITED SPORTS ACADEMY | North Sioux City | N40 Recreation & Sports | $1.5M | 0 |
| AXIOM FOUNDATION | Turton | — | $1.4M | 0 |
| DEADWOOD HISTORY INC | Deadwood | A54 Arts, Culture & Humanities | $1.4M | 0 |
| TEEN CHALLENGE OF THE DAKOTAS | Brookings | — | $1.4M | 1 |
| AMERICAN COALITION FOR ETHANOL | Sioux Falls | — | $1.4M | 2 |
| ONE SPIRIT | Rapid City | P84 Human Services | $1.4M | 0 |
| RONALD MCDONALD HOUSE CHARITIES OF | Sioux Falls | P99 Human Services | $1.4M | 1 |
| SOUTH DAKOTA HUMANITIES COUNCIL | Brookings | A700 Arts, Culture & Humanities | $1.4M | 0 |
| SOUTH DAKOTA SAFETY COUNCIL INC | Sioux Falls | — | $1.4M | 0 |
| South Dakota Association of Conservations Districts Inc | Pierre | C033 Environment | $1.4M | 11 |
| HUMANE SOCIETY OF THE BLACK HILLS | Rapid City | D200 Animal-Related | $1.4M | 1 |
| BRENDEN MANN FOUNDATION CO DORSEY & WHITNEY | Sioux Falls | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $1.4M | 3 |
| RAFT CHARITABLE FOUNDATION | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $1.4M | 1 |
| HOUSTON FAMILY FOUNDATION | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $1.4M | 6 |
| HAND COUNTY MEMORIAL HOSPITAL | Miller | E22 Health Care | $1.4M | 1 |
| NATIONAL FIELD ARCHERY ASSOCIATION | Yankton | — | $1.4M | 4 |
| ALPHA GAMMA ZETA HOUSE CORPORATION | Yankton | — | $1.4M | 0 |
| SANFORD HEALTH FOUNDATION WEST | Sioux Falls | E22I Health Care | $1.3M | 5 |
| SOUTH DAKOTA CROP IMPROVMENT ASSOCIATION | Brookings | — | $1.3M | 0 |
