| National Foundation Inc | Colorado Springs | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $4.3M | 5 |
| New Legacy Charter School | Aurora | B29 Education | $4.3M | 1 |
| GLOBAL DOWN SYNDROME FOUNDATION | Denver | E12 Health Care | $4.3M | 2 |
| DOCTORS CARE | Littleton | E30Z Health Care | $4.3M | 1 |
| Entrust | Colorado Springs | X20Z Religion-Related | $4.3M | 2 |
| SINGER FAMILY FOUNDATION | Denver | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $4.3M | 0 |
| COLORADO OUTWARD BOUND SCHOOL | Leadville | C600 Environment | $4.3M | 1 |
| ROOTED | Denver | B90 Education | $4.3M | 4 |
| AXIS International Academy | Fort Collins | B29 Education | $4.3M | 1 |
| United Way of Pueblo County Colorado Inc | Pueblo | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $4.3M | 1 |
| Paragon Behavioral Health Connections | Lakewood | F30 Mental Health & Crisis Intervention | $4.3M | 9 |
| Homeward Pikes Peak | Colorado Springs | L41 Housing & Shelter | $4.2M | 2 |
| FRANCIS HEIGHTS INC | Denver | — | $4.2M | 8 |
| Colorado International Language Academy | Colorado Springs | B29 Education | $4.2M | 0 |
| GES COALITION INC | Denver | S20 Community Improvement & Capacity Building | $4.2M | 2 |
| RINO ART DISTRICT | Denver | S41 Community Improvement & Capacity Building | $4.2M | 1 |
| HOSPICE OF THE VALLEY INC | Glenwood Springs | P74 Human Services | $4.2M | 5 |
| American Academy of Forensic Sciences | Colorado Spgs | I99Z Crime & Legal-Related | $4.2M | 1 |
| THE GREELEY COUNTRY CLUB | Greeley | — | $4.2M | 1 |
| BOULDER COUNTY UNITED FKA FC BOULDER | Lafayette | N64Z Recreation & Sports | $4.2M | 0 |
| SAN LUIS VALLEY LOCAL FOODS COALITION | Alamosa | K40 Food, Agriculture & Nutrition | $4.2M | 0 |
| St Vrain Community Montessori School | Longmont | B29 Education | $4.2M | 1 |
| KNOPH FAMILY FOUNDATION | Greeley | A20 Arts, Culture & Humanities | $4.2M | 0 |
| ST ELIZABETH'S SCHOOL | Denver | B20 Education | $4.2M | 1 |
| TEAM SUMMIT | Copper Mountain | N60 Recreation & Sports | $4.2M | 1 |
| NATIONAL CENTER FOR WOMEN AND INFORMATION TECHNOLOGY | Boulder | O53 Youth Development | $4.2M | 1 |
| Garden of the Gods Foundation | Colorado Springs | C11 Environment | $4.2M | 1 |
| NATIVE AMERICAN FISH & WILDLIFE SOCIETY | Northglenn | D033 Animal-Related | $4.2M | 1 |
| MOVEMENT ADVANCEMENT PROJECT | Boulder | R26 Civil Rights, Social Action & Advocacy | $4.2M | 7 |
| ONWARD A LEGACY FOUNDATION | Cortez | B82 Education | $4.2M | 1 |
| PEMA FOUNDATION INC | Denver | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.2M | 0 |
| ACADEMY 360 | Denver | B29 Education | $4.1M | 1 |
| ASSISI HOMES-BATAVIA APARTMENTS INC | Denver | L210 Housing & Shelter | $4.1M | 7 |
| SENIORS' RESOURCE CENTER INC | Denver | P81Z Human Services | $4.1M | 1 |
| PROJECT WORTHMORE | Aurora | P20 Human Services | $4.1M | 3 |
| MT CARMEL VETERANS SERVICE CENTER | Colorado Springs | J20 Employment | $4.1M | 0 |
| Wish of a Lifetime | Denver | P60 Human Services | $4.1M | 9 |
| CHAMPION MINISTRIES INC | Castle Rock | O55 Youth Development | $4.1M | 1 |
| ASSISI HOMES - COLONY PARK INC | Denver | — | $4.1M | 7 |
| Montbello Organizing Committee | Denver | B19 Education | $4.1M | 2 |
| Yagan Family Foundation | Boulder | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| SPRING INSTITUTE FOR INTERCULTURAL LEARNING | Denver | — | $4.1M | 1 |
| COMPASS MONTESSORI SCHOOL | Wheat Ridge | B20Z Education | $4.1M | 0 |
| Copper Mountain Resort Association | Copper Mountain | — | $4.1M | 0 |
| WIDE HORIZON INC | Wheat Ridge | E91Z Health Care | $4.1M | 1 |
| LEPTAS FOUNDATION TRUST | Denver | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| GROWING HOME INC | Westminster | X20 Religion-Related | $4.1M | 2 |
| COLORADO UPLIFT INC | Denver | B900 Education | $4.1M | 2 |
| COLORADO SOCIETY OF CPA'S | Englewood | — | $4.1M | 3 |
| Bethesda Associates | Colorado Springs | X120 Religion-Related | $4.1M | 11 |
