| FEIGIN FOUNDATION | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $30M | 0 |
| ASPIRA OF DELAWARE CHARTER OPERATIONS IN | Newark | B29 Education | $29.6M | 5 |
| Ge Li & Ning Zhao Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $29.6M | 0 |
| Jaggers Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $29.1M | 0 |
| Corbett Community Partnership Foundation aka Corbett Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $28.7M | 1 |
| THE SINGER FAMILY CHARITABLE FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $28.4M | 0 |
| The Giving Bee Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $28.2M | 0 |
| Zia & Rabia Bhatti Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $27.9M | 0 |
| GOLDEY-BEACOM COLLEGE | Wilmington | B43 Education | $26.3M | 11 |
| The White Horse Group Foundation Inc | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $26.2M | 0 |
| DELAWARE HOSPICE INC | Newark | P74Z Human Services | $25.8M | 13 |
| Burnham Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $25.1M | 0 |
| LEE INC | Wilmington | B90 Education | $24.9M | 11 |
| FILECOIN FOUNDATION FOR THE DECENTRALIZED WEB | Middletown | W05 Public & Societal Benefit | $24.6M | 0 |
| WINSTON FAMILY INITIATIVE IN TECHNOLOGY AND | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $23.4M | 3 |
| BAND Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $23.3M | 0 |
| SANFORD SCHOOL | Hockessin | B24Z Education | $23M | 5 |
| UNITED WAY OF DELAWARE | Wilmington | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $22.8M | 3 |
| GRANT-MAKING FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $22.8M | 0 |
| The McMurry Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.1M | 3 |
| MOT CHARTER SCHOOL INC | Middletown | B20 Education | $20.7M | 5 |
| WILMINGTON COUNTRY CLUB | Wilmington | — | $20.6M | 11 |
| THE MARY CAMPBELL CENTER INC | Wilmington | P700 Human Services | $20.6M | 5 |
| ROBERT AND DANA EMERY FAMILY FOUNDATION ROCKEFELLER TRUST COMPANY | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $20.6M | 1 |
| MT CUBA CENTER INC | Hockessin | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $20.3M | 3 |
| Bharat Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $20.3M | 0 |
| The Knobloch Family Foundation | Wilmington | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $20.1M | 0 |
| The Timothy and Susanne Sullivan Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $20.1M | 0 |
| EXCEPTIONAL CARE FOR CHILDREN | Newark | E20 Health Care | $19.8M | 8 |
| AURORA FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $19.3M | 1 |
| LOCAL JOBS & ECONOMIC DEVELOPMENT FUND INC | Dover | — | $19.2M | 0 |
| The Morgridge Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $19M | 4 |
| NEMOURS NEW JERSEY PHYSICIAN PRACTICE PC | Wilmington | E60 Health Care | $18.5M | 4 |
| THE MARY PARKER FOUNDATION 157823-000 | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.3M | 4 |
| BRANDYWINE COUNSELING & COMMUNITY SERVICES INC | Wilmington | F220 Mental Health & Crisis Intervention | $18.3M | 2 |
| HEAD & HEART FOUNDATION TR 12319 | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18M | 1 |
| THE TATNALL SCHOOL INC | Wilmington | B200 Education | $17.9M | 7 |
| MILTON & HATTIE KUTZ HOME INC | Wilmington | E91Z Health Care | $17.6M | 2 |
| ACADEMIA ANTONIA ALONSO CHARTER SCHOOL | Newark | B29 Education | $17M | 2 |
| FONDO CENTROAMERICANO DE MUJERES FOUNDATION | Dover | R24 Civil Rights, Social Action & Advocacy | $16.9M | 0 |
| Adobe Foundation | Wilmington | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $16.9M | 0 |
| P-Squared Philanthropies Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $16.4M | 0 |
| ANTHONY N FUSCO SR CHARITABLE FOUNDATION TRUST | Wilmington | P20 Human Services | $16.3M | 1 |
| The La Vida Feliz Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $16.3M | 0 |
| SUSSEX ACADEMY OF ARTS & SCIENCES INC | Georgetown | B24 Education | $16M | 7 |
| Donald J Slavik Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.9M | 0 |
| The Passport Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.7M | 0 |
| THE MYERS FAMILY FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.7M | 0 |
| LONGWOOD FOUNDATION INC | Wilmington | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $15.5M | 1 |
| CHARTER SCHOOL OF NEW CASTLE | New Castle | B29 Education | $15.4M | 5 |
