| FILECOIN FOUNDATION FOR THE | Middletown | W05 Public & Societal Benefit | $24.6M | 0 |
| James V Tigani Jr Muse Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $23.9M | 0 |
| WINSTON FAMILY INITIATIVE IN TECHNOLOGY AND | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $23.4M | 3 |
| Knobloch Family Foundation | Wilmington | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $23.1M | 0 |
| SANFORD SCHOOL | Hockessin | B24Z Education | $23M | 5 |
| JTMF Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $22.6M | 0 |
| FW Murphy Family Foundation | Wilmington | Z99 Unknown | $21.9M | 0 |
| Baracker Flynn Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.3M | 0 |
| AEC Trust | Wilmington | — | $21.3M | 1 |
| The McMurry Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.1M | 3 |
| MOT CHARTER SCHOOL INC | Middletown | B20 Education | $20.7M | 5 |
| WILMINGTON COUNTRY CLUB | Wilmington | — | $20.6M | 11 |
| THE MARY CAMPBELL CENTER INC | Wilmington | P700 Human Services | $20.6M | 5 |
| Bharat Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $20.3M | 0 |
| THE TATNALL SCHOOL INC | Wilmington | B200 Education | $18.9M | 7 |
| Exceptional Care for Children | Newark | E20 Health Care | $18.8M | 7 |
| BRANDYWINE COUNSELING & COMMUNITY | Wilmington | F220 Mental Health & Crisis Intervention | $18.3M | 2 |
| Wilson & Johnson Private Foundation | Wilmington | — | $18M | 0 |
| UNITED WAY OF DELAWARE | Wilmington | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $17.6M | 3 |
| MILTON & HATTIE KUTZ HOME INC | Wilmington | E91Z Health Care | $17.6M | 2 |
| The Henry Francis du Pont Winterthur | Winterthur | A510 Arts, Culture & Humanities | $17.4M | 12 |
| ACADEMIA ANTONIA ALONSO CHARTER SCHOOL | Newark | B29 Education | $17M | 2 |
| Adobe Foundation | Wilmington | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $16.9M | 0 |
| P-Squared Philanthropies Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $16.4M | 0 |
| Cadence Giving Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $16.3M | 0 |
| The La Vida Feliz Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $16.3M | 0 |
| Four D Charitable Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $16.2M | 0 |
| SUSSEX ACADEMY OF ARTS & SCIENCES INC | Georgetown | B24 Education | $16M | 7 |
| MT CUBA CENTER INC | Hockessin | — | $15.9M | 3 |
| Kuumba Academy Charter School Inc | Wilmington | B29 Education | $15.9M | 2 |
| Donald J Slavik Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.9M | 0 |
| Ge Li & Ning Zhao Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.8M | 0 |
| The Riedman Foundation | Wilmington | — | $15.7M | 0 |
| THE MYERS FAMILY FOUNDATION | Wilmington | — | $15.7M | 0 |
| Jack P and Anne R Smith Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $15.5M | 1 |
| LONGWOOD FOUNDATION INC | Wilmington | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $15.5M | 1 |
| JOSHUA M FREEMAN FOUNDATION | Selbyville | A60 Arts, Culture & Humanities | $15.3M | 5 |
| BAND Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.3M | 0 |
| The DeLuca Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $15.3M | 0 |
| The 297 Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.2M | 0 |
| DELAWARE STATE UNIVERSITY FOUNDATION INC | Dover | B11 Education | $15.1M | 3 |
| BUILDING DECARBONIZATION COALITION | Lewes | C01 Environment | $15M | 18 |
| CHARTER SCHOOL OF NEW CASTLE | New Castle | B29 Education | $14.9M | 3 |
| LA RED HEALTH CENTER INC | Georgetown | E30 Health Care | $14.8M | 10 |
| The Monarch Charitable Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $14.7M | 0 |
| NEMOURS NEW JERSEY PHYSICIAN PRACTICE PC | Wilmington | E60 Health Care | $14.5M | 5 |
| BEEBE MEDICAL FOUNDATION | Lewes | E110 Health Care | $14.4M | 4 |
| ROBERT AND DANA EMERY FAMILY FOUNDATION | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $14.3M | 1 |
| Louis and Anne Abrons Foundation Inc | Wilmington | — | $14M | 0 |
| Kelleher Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $14M | 0 |
