| STRADA PHILANTHROPY INC | Indianapolis | B02 Education | $19.2M | 7 |
| BLUE RIVER SERVICES INC | Corydon | — | $19M | 3 |
| CROSSROADS REHABILITATION CENTER INC | Indianapolis | E50Z Health Care | $18.9M | 6 |
| AGING AND IN-HOME SERVICES OF NORTHEAST INDIANA INC | Fort Wayne | P81Z Human Services | $18.9M | 2 |
| EARLY LEARNING INDIANA INC | Indianapolis | P330 Human Services | $18.9M | 7 |
| PURDUE POLYTECHNIC HIGH SCHOOL OF INDIANAPOLIS INC | Indianapolis | B29 Education | $18.8M | 8 |
| DirectEmployers Association Inc | Indianapolis | Y03 Mutual & Membership Benefit | $18.8M | 8 |
| COMMUNITY FOUNDATION ALLIANCE INC | Evansville | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $18.8M | 2 |
| Indiana University Health Blackford Hospital Inc | Indianapolis | E22 Health Care | $18.7M | 17 |
| SAM SHINE FOUNDATION INC | Greenville | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $18.7M | 1 |
| AMERICAN COLLEGE OF SPORTS MEDICINE INC | Indianapolis | B54Z Education | $18.6M | 9 |
| AWS FOUNDATION INC | Fort Wayne | P82 Human Services | $18.4M | 4 |
| LAGRANGE COUNTY RURAL ELECTRIC MEMBERSHIP CORPORATION | LaGrange | — | $18.4M | 13 |
| AHEPA AFFORDABLE HOUSING MANAGEMENT COMPANY INC | Fishers | L800 Housing & Shelter | $18.3M | 7 |
| Beacon Health Foundation Inc | South Bend | E11 Health Care | $18.3M | 3 |
| WABASH VALLEY COMMUNITY FOUNDATION INC | Terre Haute | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $18.3M | 1 |
| GRANT-BLACKFORD MENTAL HEALTH INC | Marion | — | $18.2M | 11 |
| SWISS VILLAGE INC | Berne | P75Z Human Services | $18.2M | 6 |
| FORT WAYNE ZOOLOGICAL SOCIETY INC | Fort Wayne | D115 Animal-Related | $18.2M | 7 |
| PORTER COUNTY COMMUNITY FOUNDATION INC | Valparaiso | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $18.1M | 4 |
| The Oaks Academy Inc | Indianapolis | B24 Education | $18M | 7 |
| National Federation of State High School Associations | Indianapolis | — | $18M | 10 |
| EDUCATION AT WORK INC | Indianapolis | — | $18M | 12 |
| FULTON COUNTY REMC | Rochester | Y22 Mutual & Membership Benefit | $17.8M | 14 |
| UNITED ASSOCIATION OF JOURNEYMEN PLUMBERS & STEAMFITTERS LOCAL UNION 440 | Indianapolis | — | $17.7M | 20 |
| Golden Years Homestead Inc | Fort Wayne | E91Z Health Care | $17.5M | 0 |
| VICTORY COLLEGE PREP INC | Indianapolis | B29 Education | $17.5M | 2 |
| INDIANA HISTORICAL SOCIETY | Indianapolis | A800 Arts, Culture & Humanities | $17.5M | 5 |
| HUMAN SERVICES INC | Columbus | — | $17.4M | 1 |
| PUTNAM COUNTY COMPREHENSIVE SERVICES INC | Greencastle | P20Z Human Services | $17.3M | 0 |
| BEST ONE TIRE O-K-T EMPLOYEES' BENEFICIARY TRUST AGREEMENT | Monroe | Y43 Mutual & Membership Benefit | $17.2M | 0 |
| INSIDE TRACK INC | Indianapolis | — | $17.1M | 15 |
| Noble Inc | Indianapolis | P82Z Human Services | $17.1M | 2 |
| YOUTH OPPORTUNITY CENTER INC | Muncie | I440 Crime & Legal-Related | $17.1M | 4 |
| COMMUNITY ACTION PROGRAM OF EVANSVILLE AND VANDERBURGH COUNTY INC | Evansville | P20Z Human Services | $17M | 3 |
| WOMEN'S CARE CENTER INC | South Bend | E400 Health Care | $16.9M | 4 |
| Community LTC Inc | Anderson | E910 Health Care | $16.9M | 3 |
| THE CENTER FOR HOSPICE & PALLIATIVE CARE INC | Mishawaka | P74 Human Services | $16.9M | 7 |
| Kiwanis International Inc | Indianapolis | — | $16.7M | 17 |
| HVAF OF INDIANA INC | Indianapolis | L41 Housing & Shelter | $16.7M | 3 |
| BONA VISTA PROGRAMS INC | Kokomo | I19 Crime & Legal-Related | $16.6M | 3 |
| American Legion Charities Inc | Indianapolis | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $16.6M | 3 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF SOUTHWESTERN INDIANA INC | Evansville | P27Z Human Services | $16.6M | 5 |
| ALPHA CHI OMEGA FRATERNITY INC | Indianapolis | — | $16.6M | 6 |
| RIVER HERITAGE CONSERVANCY INC | Jeffersonville | N03 Recreation & Sports | $16.5M | 3 |
| AMERICAN CAMPING ASSOCIATION INC | Martinsville | — | $16.5M | 7 |
| COMMUNITY FOUNDATION OF WABASH COUNTY INC | North Manchester | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $16.4M | 1 |
| PRAIRIE LANDING COMMUNITY INC | Indianapolis | L22 Housing & Shelter | $16.4M | 7 |
| INSTITUTE FOR QUALITY EDUCATION INC | Indianapolis | B99Z Education | $16.4M | 1 |
| VISIT INDY INC | Indianapolis | — | $16.4M | 11 |
