| JOHN H BONER COMMUNITY CENTER INC | Indianapolis | — | $22.6M | 3 |
| Eskenazi Health Foundation Inc | Indianapolis | E02 Health Care | $22.5M | 7 |
| BOARD OF CERTIFIED SAFETY PROFESSIONALS | Indianapolis | S41Z Community Improvement & Capacity Building | $22.5M | 9 |
| INDIANA STATE TEACHERS ASSOCIATION | Indianapolis | J40 Employment | $22.2M | 10 |
| Conner Prairie Museum Inc | Fishers | A54 Arts, Culture & Humanities | $22.1M | 7 |
| LOCAL 212 IBEW HEALTH & WELFARE TRUST FUND | Indianapolis | — | $22.1M | 4 |
| KNOX COUNTY ASSOCIATION FOR REMARKABLE CITIZENS INC | Vincennes | P82Z Human Services | $22M | 3 |
| NORTHEASTERN CENTER INC | Kendallville | F30Z Mental Health & Crisis Intervention | $21.8M | 9 |
| OUR HOSPICE OF SOUTH CENTRAL INDIANA INC | Columbus | P74I Human Services | $21.7M | 6 |
| ALPHA CHI OMEGA NATIONAL HOUSING CORPORATION | Indianapolis | — | $21.7M | 2 |
| DEKKO FOUNDATION INC | Kendallville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.7M | 1 |
| FAMILY DEVELOPMENT SERVICES INC | Indianapolis | J20 Employment | $21.5M | 2 |
| Indiana State University Foundation Inc | Terre Haute | B110 Education | $21.4M | 5 |
| VISITING NURSE & HOSPICE HOME INC | Fort Wayne | E91Z Health Care | $21.4M | 9 |
| SOUTH BEND MEDICAL FOUNDATION | South Bend | E600 Health Care | $21.4M | 10 |
| SYCAMORE REHABILITATION SERVICES HENDRICKS COUNTY ARC INC | Danville | P820 Human Services | $21.2M | 4 |
| FOOD BANK OF NORTHWEST INDIANA INC | Merrillville | K31Z Food, Agriculture & Nutrition | $21.2M | 1 |
| DEACONESS SPECIALTY PHYSICIANS INC | Evansville | E32 Health Care | $21.1M | 11 |
| INTERLOCAL COMMUNITY ACTION PROGRAM INC | New Castle | P20Z Human Services | $21.1M | 1 |
| Lasting Change INC | Fort Wayne | I440 Crime & Legal-Related | $21M | 8 |
| LifeStream Services Inc | Yorktown | P810 Human Services | $21M | 2 |
| 21st Century Charter School of Gary co GEO Foundation | Indianapolis | B29 Education | $21M | 0 |
| THE VOICE OF GOD RECORDINGS INC | Jeffersonville | X800 Religion-Related | $20.8M | 2 |
| Indiana Credit Union League Inc | Indianapolis | — | $20.7M | 7 |
| FOOD FINDERS FOOD BANK INC | Lafayette | K31Z Food, Agriculture & Nutrition | $20.7M | 1 |
| EVANSVILLE GOODWILL INDUSTRIES INC | Evansville | J32Z Employment | $20.6M | 5 |
| MENTAL HEALTH ASSOCIATION IN INDIANA INC | Indianapolis | F80Z Mental Health & Crisis Intervention | $20.6M | 4 |
| INDIANA HEALTH INFORMATION EXCHANGE INC | Indianapolis | E112 Health Care | $20.4M | 17 |
| WABASH CENTER INC | Lafayette | P200 Human Services | $20.2M | 2 |
| THE DAMIEN CENTER | Indianapolis | P20 Human Services | $20.2M | 3 |
| INDIANAKENTUCKYOHIO REG COUNCIL OF CARPENTERS JT APPRENTICE & TRAINING FUND | Warsaw | B30 Education | $20.1M | 7 |
| TRADEWINDS SERVICES INC | Merrillville | E500 Health Care | $20.1M | 8 |
| HABITAT FOR HUMANITY OF GREATER INDIANAPOLIS INC | Indianapolis | L20Z Housing & Shelter | $20M | 3 |
| PALADIN INC | Michigan City | P820 Human Services | $20M | 1 |
| THE ASSOCIATION OF ILLIANA CHRISTIAN HIGH SCHOOL OF INDIANA INC | Dyer | — | $20M | 4 |
| HOOSIER UPLANDS ECONOMIC DEVELOPMENT CORPORATION | Mitchell | S32Z Community Improvement & Capacity Building | $20M | 6 |
| Hubbard Hill Estates Inc | Elkhart | L22 Housing & Shelter | $19.9M | 5 |
| PLUMBERS AND STEAMFITTERS LOCAL 166 HEALTH AND WELFARE BENEFIT PLAN | Fort Wayne | — | $19.9M | 0 |
| HERITAGE AND RESEARCH CENTER AT SAINT MARYS INC | Notre Dame | X22 Religion-Related | $19.8M | 0 |
| CALUMET COLLEGE OF ST JOSEPH | Whiting | B42Z Education | $19.7M | 9 |
| DEACONESS ILLINOIS SPECIALTY CLINIC INC | Evansville | E30 Health Care | $19.6M | 9 |
| COMMUNITY HEALTH NETWORK FOUNDATION INC | Indianapolis | E122 Health Care | $19.6M | 11 |
| INDIANA PLASTERERS & CEMENT MASONS HEALTH & WEL FUND | Indianapolis | — | $19.5M | 1 |
| Bashor Home of The United Methodist Church Inc | Goshen | P300 Human Services | $19.4M | 7 |
| HOLY CROSS VILLAGE AT NOTRE DAME INC | Notre Dame | — | $19.4M | 7 |
| CANTERBURY SCHOOL INC | Fort Wayne | B20Z Education | $19.4M | 2 |
| USA FOOTBALL INC | Indianapolis | N70 Recreation & Sports | $19.4M | 8 |
| RIGGS COMMUNITY HEALTH CENTER INC | Lafayette | E20Z Health Care | $19.4M | 7 |
| MARSHALL COUNTY RURAL ELECTRIC MEMBERSHIP CORP | Plymouth | W80 Public & Societal Benefit | $19.4M | 15 |
| Gibault Inc | Terre Haute | B280 Education | $19.3M | 4 |
