| WELLS RURAL ELECTRIC COMPANY | Wells | — | $50.2M | 23 |
| ALEXANDER DAWSON FOUNDATION | Las Vegas | B200 Education | $49.5M | 11 |
| MATER ACADEMY OF NEVADA | Las Vegas | B29 Education | $49.2M | 3 |
| LAS VEGAS SUPER BOWL HOST COMMITTEE | Las Vegas | — | $47.6M | 3 |
| GREAT BASIN INSTITUTE | Reno | C60 Environment | $45.9M | 1 |
| THE SMITH CENTER FOR THE PERFORMING ARTS | Las Vegas | A61 Arts, Culture & Humanities | $44.8M | 11 |
| Tahoe Community Foundation | Incline Village | B120 Education | $44.2M | 2 |
| BIT HOLDINGS THREE INC | Las Vegas | — | $43.3M | 0 |
| MT WHEELER POWER INC | Ely | — | $42.7M | 18 |
| ALLIANCE FOR CHILDHOOD DISEASES | Las Vegas | E32 Health Care | $41.8M | 10 |
| BPS FOUNDATION | Las Vegas | — | $41.3M | 0 |
| LEGAL AID CENTER OF SOUTHERN | Las Vegas | R20 Civil Rights, Social Action & Advocacy | $39.6M | 7 |
| BOULDER DAM CREDIT UNION | Boulder City | — | $38.8M | 8 |
| Catholic Charities of Southern Nevada | Las Vegas | P200 Human Services | $38.7M | 8 |
| Community Foundation of Northern Nevada | Reno | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $38.4M | 4 |
| NEVADA AFFORDABLE HOUSING | Las Vegas | L20 Housing & Shelter | $37.9M | 1 |
| TEAMSTERS SECURITY FUND FOR SOUTHERN | Las Vegas | — | $37.4M | 1 |
| COMMUNITY HEALTH ALLIANCE | Reno | — | $37M | 6 |
| OPPORTUNITY VILLAGE | Las Vegas | J330 Employment | $36.9M | 10 |
| Nathan Adelson Hospice Inc | Las Vegas | P74 Human Services | $35.1M | 7 |
| UNITE HERE LOCAL UNION 226 | Las Vegas | — | $35M | 19 |
| Boulder City Hospital Inc | Boulder City | E220 Health Care | $33.2M | 9 |
| LAS VEGAS EVENTS INC | Las Vegas | — | $33.2M | 7 |
| RITE OF PASSAGE ADOLESCENT TREATMENT CENTERS AND S | Minden | — | $32.5M | 6 |
| ENGELSTAD FAMILY FOUNDATION | Las Vegas | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $32.3M | 5 |
| CONSTRUCTION INDUSTRY AND LABORERS HEALTH AND WELFARE PLAN | Las Vegas | — | $31.1M | 1 |
| SIERRA MEDICAL SERVICES ALLIANCE | Reno | E62 Health Care | $30.8M | 8 |
| The Meadows School | Las Vegas | B200 Education | $30.7M | 6 |
| HELP OF SOUTHERN NEVADA | Las Vegas | P200 Human Services | $30.1M | 4 |
| SCHOOL ADMINISTRATOR'S WELFARE TRUST | Las Vegas | — | $29.7M | 0 |
| WVC | Las Vegas | D024 Animal-Related | $28.4M | 30 |
| SAGEBRUSH HEALTH SERVICES | Las Vegas | P20 Human Services | $27.3M | 1 |
| BOYS AND GIRLS CLUB OF TRUCKEE MEADOWS | Reno | O23I Youth Development | $26.8M | 7 |
| OPPORTUNITY VILLAGE FOUNDATION | Las Vegas | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $26.7M | 3 |
| THE VILLAGE SOUTH INC | Las Vegas | F320 Mental Health & Crisis Intervention | $26.4M | 5 |
| NEVADA CHARTER ACADEMIES | Las Vegas | B29 Education | $26.3M | 2 |
| UNIVERSITY STUDIES ABROAD CONSORTIUM | Reno | B99 Education | $25.1M | 4 |
| HEMOSTASIS AND THROMBOSIS CENTER OF | Las Vegas | G80 Diseases, Disorders & Medical Disciplines | $24.1M | 8 |
| LAS VEGAS CLARK COUNTY | Las Vegas | B117 Education | $24M | 0 |
| NEVADA VIRTUAL CHARTER SCHOOL | Las Vegas | B29 Education | $23.7M | 2 |
| WESTCARE FOUNDATION INC | Las Vegas | P43 Human Services | $23.5M | 5 |
| THE JUST ONE PROJECT | Las Vegas | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $22.6M | 1 |
| THE NICHOLAS & DOROTHY CUMMINGS | Reno | B82Z Education | $21.6M | 1 |
| UBC NATIONAL JOB CORPS TRAINING | Las Vegas | J22 Employment | $21.5M | 6 |
| GAY & LESBIAN COMMUNITY CENTER | Las Vegas | P99Z Human Services | $21M | 8 |
| NEW GENERATION FOUNDATION INC | Las Vegas | — | $20.9M | 5 |
| CORAL ACADEMY OF SCIENCE RENO | Reno | B29 Education | $20.9M | 5 |
| DR MIRIAM AND SHELDON G ADELSON | Las Vegas | — | $20.5M | 9 |
| The Skip Viragh Foundation Inc | Reno | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $20.4M | 3 |
| NORTHERN NEVADA OPERATING ENGINEERS | Reno | — | $20.3M | 0 |
