| SMALL BUSINESS INVESTMENT CORPORATION | Tijeras | S30 Community Improvement & Capacity Building | $31M | 1 |
| HOMEWISE INC | Santa Fe | — | $30.5M | 12 |
| Plumbers & Pipefitters LU No 286 H&W Fund | Albuquerque | — | $28.5M | 0 |
| AMERICAN SOCIETY OF RADIOLOGIC TECHNOLOGISTS | Albuquerque | — | $26.9M | 19 |
| PUBLIC SERVICE COMPANY OF NM BENEFIT TRUST | Albuquerque | — | $26.7M | 0 |
| Southwestern Electric Cooperative Inc | Clayton | — | $26.7M | 8 |
| SANTA FE COMMUNITY FOUNDATION | Santa Fe | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $26.2M | 5 |
| SOCORRO ELECTRIC COOPERATIVE INC | Socorro | — | $25.7M | 17 |
| EL CENTRO FAMILY HEALTH | Espanola | E39Z Health Care | $23.9M | 10 |
| ESPANOLA VALLEY HUMANE SOCIETY | Espanola | D200 Animal-Related | $23.9M | 3 |
| THE CLUB AT LAS CAMPANAS INC | Santa Fe | N20 Recreation & Sports | $23.8M | 6 |
| CREDIT UNIONS IN THE STATE OF NEW MEXICO | Santa Fe | — | $22.9M | 6 |
| HIDALGO MEDICAL SERVICES | Lordsburg | — | $22.5M | 8 |
| THE FOOD DEPOT | Santa Fe | P20Z Human Services | $22.4M | 4 |
| EL CASTILLO RETIREMENT RESIDENCES | Santa Fe | — | $21.7M | 7 |
| FIRST NATIONS COMMUNITY HEALTHSOURCE | Albuquerque | E32 Health Care | $21.6M | 5 |
| BORDER SERVANT CORPS INC | Las Cruces | — | $21.3M | 2 |
| CORIO FOUNDATION | Los Ranchos | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.2M | 0 |
| LA FAMILIA MEDICAL CENTER | Santa Fe | — | $21.1M | 10 |
| ENMRSH Inc | Clovis | J330 Employment | $21M | 2 |
| REALTY GIFT FUND | Santa Fe | C34 Environment | $20.8M | 3 |
| ALBUQUERQUE COMMUNITY FOUNDATION | Albuquerque | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $20.8M | 3 |
| TRESCO INC | Las Cruces | P700 Human Services | $20.7M | 2 |
| SPRINGER ELECTRIC COOPERATIVE INC | Springer | W80 Public & Societal Benefit | $20.3M | 11 |
| SANTA FE RECOVERY CENTER INC | Santa Fe | F22 Mental Health & Crisis Intervention | $20.2M | 7 |
| THE HORSE SHELTER | Cerrillos | D200 Animal-Related | $19.7M | 1 |
| ROOSEVELT COUNTY ELECTRIC COOPERATIVE INC | Portales | — | $19.6M | 13 |
| New Mexico Pipetrades Health & Welfare | Albuquerque | — | $19.4M | 0 |
| KROSSROADS INTEGRATIVE HEALTH AND RECOVERY SOLUTIONS INC | Santa Fe | F30 Mental Health & Crisis Intervention | $18.8M | 3 |
| Navajo Preparatory School Inc | Farmington | B25Z Education | $18.6M | 6 |
| UNITED WAY OF SOUTHWEST NM INC | Las Cruces | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $18.4M | 1 |
| Carroll Petrie Foundation | Santa Fe | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $17.8M | 2 |
| NEW MEXICO EDUCATIONAL ASSISTANCE FOUNDATION | Albuquerque | B820 Education | $17.6M | 6 |
| University of the Southwest | Hobbs | B420 Education | $17.5M | 8 |
| SANDIA SCHOOL | Albuquerque | B240 Education | $17.5M | 4 |
| ALBUQUERQUE CONVENTION & VISITORS BUREAU | Albuquerque | — | $17.4M | 5 |
| ALBUQUERQUE INTERNATIONAL BALLOON FIESTA INC | Albuquerque | N520 Recreation & Sports | $17.3M | 5 |
| HOPE CHRISTIAN SCHOOLS INC | Albuquerque | B24Z Education | $17M | 3 |
| LA VIDA LLENA | Albuquerque | — | $16.4M | 0 |
| Clayton Health Systems Inc | Clayton | E22Z Health Care | $15.7M | 6 |
| NATIVE FORWARD SCHOLARS FUND | Albuquerque | B82Z Education | $15.6M | 3 |
| COLUMBUS ELECTRIC COOPERATIVE INC | Deming | — | $15.5M | 14 |
| La Casa De Buena Salud Inc | Portales | — | $15.5M | 8 |
| LAKEVIEW CHRISTIAN HOME OF THE SOUTHWEST INC | Carlsbad | E910 Health Care | $15.3M | 1 |
| UNITED WAY OF NORTH CENTRAL NEW MEXICO | Albuquerque | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $15.2M | 5 |
| CNM INGENUITY INC | Albuquerque | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $15.2M | 3 |
| My Journey | Los Lunas | — | $15.2M | 3 |
| SUNRISE CLINICS | Santa Rosa | E22 Health Care | $15.1M | 10 |
| DREAMSPRING | Albuquerque | S43B Community Improvement & Capacity Building | $14.5M | 8 |
| CENTER FOR ACTION AND CONTEMPLATION | Albuquerque | A70 Arts, Culture & Humanities | $14.4M | 6 |
