| Saint Francis Hospital Inc | Tulsa | E220 Health Care | $1.8B | 11 |
| INTEGRIS Baptist Medical Center Inc | Oklahoma City | E220 Health Care | $1.2B | 13 |
| MERCY HOSPITAL OKLAHOMA CITY | Oklahoma City | E220 Health Care | $810.2M | 20 |
| George Kaiser Family Foundation | Tulsa | T110 Philanthropy, Voluntarism & Grantmaking Foundations | $549.7M | 10 |
| COMMUNITYCARE GOVERNMENT PROGRAMS INC | Tulsa | — | $475.4M | 7 |
| INTEGRIS Health INC | Oklahoma City | E210 Health Care | $437.7M | 31 |
| FEED THE CHILDREN INC | Oklahoma City | Q330 International, Foreign Affairs & National Security | $408.9M | 12 |
| The University of Tulsa | Tulsa | B42 Education | $330.3M | 14 |
| TULSA COMMUNITY FOUNDATION | Tulsa | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $329.5M | 7 |
| INTEGRIS So Oklahoma City Hosp Corp dba INTEGRIS Southwest Medical Center I nc | Oklahoma City | E220 Health Care | $317M | 15 |
| INTEGRIS Rural Health Inc | Oklahoma City | E200 Health Care | $307.1M | 15 |
| DELTA DENTAL PLAN OF OKLAHOMA | Oklahoma City | — | $296.1M | 31 |
| Charles and Lynn Schusterman Family Foundation | Tulsa | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $294.6M | 0 |
| INTEGRIS Ambulatory Care Corp | Oklahoma City | E320 Health Care | $275.1M | 12 |
| COMMUNITY STRATEGIES INC DBA EPIC CHARTER SCHOOLS | Oklahoma City | W19 Public & Societal Benefit | $266.3M | 5 |
| Oklahoma State University Foundation | Stillwater | B110 Education | $242.7M | 12 |
| Saint Francis Hospital South LLC | Tulsa | E20 Health Care | $227.2M | 10 |
| Warren Clinic Inc | Tulsa | E32Z Health Care | $224.5M | 10 |
| UNIVERSITY OF OKLAHOMA FOUNDATION INC | Norman | B110 Education | $218.7M | 12 |
| Saint Francis Hospital Muskogee Inc | Tulsa | E20 Health Care | $218.6M | 11 |
| MERCY CLINIC OKLAHOMA COMMUNITIESINC | Oklahoma City | E30 Health Care | $215.9M | 18 |
| Duncan Regional Hospital | Duncan | E220 Health Care | $214.3M | 13 |
| GRAND LAKE MENTAL HEALTH CENTER INC | Tulsa | F30Z Mental Health & Crisis Intervention | $206.9M | 24 |
| MERCY HOSPITAL ARDMORE | Ardmore | E20 Health Care | $202.4M | 10 |
| ORAL ROBERTS UNIVERSITY | Tulsa | B430 Education | $192.9M | 10 |
| Oklahoma Blood Institute | Oklahoma City | E61Z Health Care | $146.2M | 27 |
| INTEGRIS Health Edmond Inc | Oklahoma City | E22 Health Care | $138.8M | 13 |
| MERCY HOSPITAL ADA INC | Ada | — | $138.3M | 11 |
| FAMILY & CHILDRENS SERVICES INC | Tulsa | P400 Human Services | $134.1M | 8 |
| Oklahoma Medical Research Foundation | Oklahoma City | H920 Medical Research | $132.3M | 17 |
| The Children's Center Inc | Bethany | E910 Health Care | $131.5M | 12 |
| OKLAHOMA CITY UNIVERSITY | Oklahoma City | B430 Education | $122M | 18 |
| REGIONAL FOOD BANK OF OKLAHOMA INC | Oklahoma City | K310 Food, Agriculture & Nutrition | $115.6M | 8 |
| THE SAMUEL ROBERTS NOBLE FOUNDATION | Ardmore | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $114.2M | 17 |
| OKLAHOMA CITY COMMUNITY FOUNDATION INC | Oklahoma City | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $107M | 12 |
| TRI-COUNTY ELECTRIC COOPERATIVE INC | Hooker | — | $103.8M | 21 |
| ASBJORNSON FOUNDATION | Tulsa | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $101.6M | 0 |
| CREOKS MENTAL HEALTH SERVICES | Tulsa | F30Z Mental Health & Crisis Intervention | $98.3M | 14 |
| VARIETY CARE INC | Oklahoma City | E32Z Health Care | $97.8M | 16 |
| Oklahoma Baptist University | Shawnee | B420 Education | $96.6M | 8 |
| VERDIGRIS VALLEY ELECTRIC COOPERATIVE INC | Collinsville | — | $93.6M | 20 |
| CENTRAL OKLAHOMA AMERICAN INDIAN HEALTH COUNCIL INC | Oklahoma City | E320 Health Care | $92.6M | 16 |
| NORTHEAST OKLAHOMA ELECTRIC COOPERATIVE INC | Vinita | — | $90.2M | 16 |
| CKENERGY ELECTRIC COOPERATIVE INC | Binger | — | $88.6M | 22 |
| COTTON ELECTRIC COOPERATIVE INC | Walters | — | $83.2M | 18 |
| Canadian Valley Electric Cooperative Inc | Seminole | — | $81.9M | 16 |
| CENTRAL RURAL ELECTRIC COOPERATIVE INC | Stillwater | — | $77.6M | 17 |
| CIMARRON ELECTRIC COOPERATIVE INC | Kingfisher | — | $76M | 19 |
| LAKE REGION ELECTRIC COOPERATIVE INC | Hulbert | — | $74.4M | 16 |
| Citgo Petroleum Corporation Employees' Benefit Trust | Tulsa | — | $73.8M | 1 |
