| FORSYTH COUNTRY CLUB | Winstonsalem | — | $16.2M | 6 |
| CORVIAN COMMUNITY SCHOOL INC | Charlotte | B29 Education | $16.2M | 3 |
| Lutheran Home at Trinity Oaks Inc | Salisbury | — | $16.2M | 7 |
| Lutheran Home - Hickory West Inc | Salisbury | — | $16M | 6 |
| NORTH CAROLINA INSURANCE GUARANTY ASSOCI | Raleigh | — | $16M | 7 |
| Carolina Golf Club Inc | Charlotte | — | $16M | 3 |
| NORTH CAROLINA MUSEUM OF LIFE & | Durham | A560 Arts, Culture & Humanities | $15.9M | 5 |
| COASTAL COMMUNITY ACTION INC | Newport | — | $15.9M | 0 |
| Thomas Jefferson Classical Academy | Mooresboro | B20 Education | $15.8M | 3 |
| Yadkin Valley Economic Development District Inc | Boonville | P20 Human Services | $15.8M | 1 |
| NEW YORK UNIVERSITY SCHOOL OF MEDICINE | Charlotte | — | $15.8M | 1 |
| Gaston County Family YMCA | Gastonia | — | $15.7M | 2 |
| Cornerstone Charter Academy A Challenge Foundation Academy Inc | Greensboro | B29 Education | $15.7M | 3 |
| UNITED WAY OF NORTH CAROLINA | Cary | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $15.7M | 1 |
| INVEST COLLEGIATE IMAGINE INC | Asheville | B29 Education | $15.7M | 1 |
| ELDERHAUS INC | Wilmington | — | $15.6M | 6 |
| Leadership Schools of Johnston County | Clayton | B29 Education | $15.6M | 0 |
| Cabarrus Cooperative Christian Ministry | Concord | — | $15.5M | 1 |
| IMPACT HEALTH | Asheville | E60 Health Care | $15.5M | 9 |
| Columbus Regional Health Network | Whiteville | E30 Health Care | $15.5M | 3 |
| COMMUNITY FOUNDATION OF GREATER | Greensboro | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $15.4M | 7 |
| STANLEY TOTAL LIVING CENTER INC | Stanley | P75Z Human Services | $15.4M | 2 |
| PI KAPPA PHI PROPERTIES INC | Charlotte | — | $15.4M | 3 |
| God's World Publications Inc | Asheville | X830 Religion-Related | $15.3M | 10 |
| DUKE INTEGRATED NETWORK INC | Durham | E60 Health Care | $15.3M | 12 |
| The Asha and Sajjan Agarwal Foundation | Raleigh | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $15.1M | 0 |
| CAPE FEAR COMMUNITY COLLEGE | Wilmington | B20 Education | $15.1M | 0 |
| ARMC PHYSICIANS CARE INC | Greensboro | E22 Health Care | $15M | 11 |
| NORTH CAROLINA SYMPHONY SOCIETY INC | Raleigh | A690 Arts, Culture & Humanities | $14.9M | 7 |
| Triad Adult & Pediatric Medicine Inc | Greensboro | E30Z Health Care | $14.8M | 9 |
| MERANCAS FOUNDATION INC | Charlotte | — | $14.8M | 1 |
| ANGEL MINISTRIES | Raleigh | X20Z Religion-Related | $14.8M | 3 |
| UNITY CLASSICAL CHARTER SCHOOL | Charlotte | B29 Education | $14.7M | 0 |
| SPOTSWOOD CHARITABLE FOUNDATION INC | Morehead City | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $14.6M | 1 |
| HOT SPRINGS HEALTH PROGRAM | Marshall | — | $14.6M | 9 |
| ISOTHERMAL PLANNING AND DEVELOPMENT | Rutherfordton | U00J Science & Technology | $14.6M | 1 |
| COOPERRIIS INC | Mill Spring | F33 Mental Health & Crisis Intervention | $14.5M | 6 |
| Triangle Education Organization | Holly Springs | B29 Education | $14.5M | 3 |
| DOROTHEA DIX PARK CONSERVANCY | Raleigh | N32 Recreation & Sports | $14.5M | 2 |
| NORTH CAROLINA ZOOLOGICAL SOCIETY INC | Asheboro | D50 Animal-Related | $14.5M | 2 |
| Young Mens Christian Association of High Point Inc | High Point | P27Z Human Services | $14.5M | 5 |
| HEALING TRANSITIONS INC | Raleigh | F200 Mental Health & Crisis Intervention | $14.5M | 0 |
| LOOMIS FAMILY FOUNDATION INC | Greensboro | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $14.4M | 1 |
| EASTERN CAROLINA VOCATIONAL CENTER | Greenville | J300 Employment | $14.4M | 10 |
| MIRACLES IN SIGHT | Winston Salem | — | $14.3M | 5 |
| DIVERS ALERT NETWORK | Durham | N67C Recreation & Sports | $14.3M | 3 |
| QUEEN'S GRANT COMMUNITY SCHOOL INC | Mint Hill | B24 Education | $14.3M | 0 |
| LOUISBURG COLLEGE | Louisburg | — | $14.2M | 2 |
| CALDWELL ACADEMY | Greensboro | B21Z Education | $14.2M | 2 |
| BRIDGE TO TURKIYE | Chapel Hill | M20 Public Safety, Disaster Preparedness & Relief | $14.2M | 0 |
