| THE CEDARS OF CHAPEL HILL CLUB INC | Chapel Hill | P80 Human Services | $18.9M | 0 |
| INSIGHT HUMAN SERVICES INC | Winstonsalem | F200 Mental Health & Crisis Intervention | $18.9M | 3 |
| CABARRUS ROWAN COMMUNITY HEALTH CENTERS INC | Concord | E32 Health Care | $18.8M | 11 |
| Reinvestment Partners | Durham | S99Z Community Improvement & Capacity Building | $18.7M | 2 |
| COMMUNITY SCHOOL OF DAVIDSON INC | Davidson | B29 Education | $18.7M | 4 |
| NC FARM BUREAU FEDERATION INC | Raleigh | — | $18.6M | 4 |
| ST DAVID'S SCHOOL | Raleigh | B250 Education | $18.6M | 5 |
| Bradford Preparatory School | Charlotte | B29 Education | $18.5M | 4 |
| RESCUE MISSIONS MINISTRIES INC | Durham | — | $18.5M | 1 |
| VOYAGER ACADEMY INC | Durham | B29 Education | $18.4M | 3 |
| Lutheran Home - Hickory Inc | Salisbury | — | $18.4M | 5 |
| NATIONAL BOARD FOR CERTIFIED COUNSELORS INC | Greensboro | — | $18.3M | 7 |
| THE GAMBRELL FOUNDATION | Charlotte | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.3M | 4 |
| BONNIE CONE CLASSICAL ACADEMY INC | Huntersville | B29 Education | $18.2M | 0 |
| CAROLINA SENIORCARE | Newton | E50 Health Care | $18.2M | 8 |
| CHARLES A CANNON TRUST NO 1 | Concord | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $18.2M | 5 |
| THE FRANKLIN ACADEMY INC | Wake Forest | B24 Education | $18.1M | 1 |
| PISGAH LEGAL SERVICES | Asheville | I80Z Crime & Legal-Related | $18.1M | 8 |
| TRANSYLVANIA VOCATIONAL SERVICES IN | Brevard | B122 Education | $18M | 7 |
| Youth Enrichment Program of Wilson | Wilson | — | $18M | 0 |
| Lutheran Retirement Center - Wilmington Inc | Salisbury | — | $17.9M | 7 |
| FORSYTH COUNTRY CLUB | Winstonsalem | — | $17.9M | 8 |
| GUILFORD COUNTY PARTNERSHIP FOR CHILDREN INC | Greensboro | B012 Education | $17.9M | 2 |
| Community Affordable Housing Equity Corporation | Raleigh | L99Z Housing & Shelter | $17.8M | 10 |
| CLASSROOM CENTRAL INC | Charlotte | B112 Education | $17.7M | 1 |
| FOOD BANK OF THE ALBEMARLE | Elizabeth City | K31Z Food, Agriculture & Nutrition | $17.7M | 1 |
| WAYNE ACTION GROUP FOR ECONOMIC SOLVENCY INC | Goldsboro | P20 Human Services | $17.7M | 2 |
| MEREDITH SLANE FINCH MICHENER FOUNDATION INC | High Point | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $17.7M | 0 |
| FAMILIES AND COMMUNITIES RISING INC | Durham | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $17.6M | 5 |
| TRINITY SCHOOL OF DURHAM & CHAPEL HILL AND CHAPEL HILL INC | Durham | B20Z Education | $17.5M | 4 |
| NATIONAL COUNCIL FOR AIR AND STREAM IMPROVEMENT INC | Cary | — | $17.5M | 10 |
| CHARLOTTE SYMPHONY ORCHESTRA SOCIETY INC | Charlotte | A690 Arts, Culture & Humanities | $17.4M | 7 |
| NCHA INC | Raleigh | — | $17.4M | 15 |
| Alleghany County Memorial Hospital Inc | Sparta | E22 Health Care | $17.4M | 6 |
| LIONS SERVICES INC | Charlotte | S80Z Community Improvement & Capacity Building | $17.4M | 1 |
| LSA Management Inc | Salisbury | — | $17.4M | 9 |
| Crisis Assistance Ministry | Charlotte | P60Z Human Services | $17.3M | 6 |
| COVENANT VILLAGE INC | Gastonia | P75Z Human Services | $17.2M | 7 |
| WAKE CHRISTIAN ACADEMY INC | Raleigh | B24Z Education | $17.2M | 1 |
| INTERNATIONAL SOCIETY OF AUTOMATION | Durham | U030 Science & Technology | $17.2M | 9 |
| Aston Park Health Care Center Inc | Salisbury | T30Z Philanthropy, Voluntarism & Grantmaking Foundations | $17.1M | 9 |
| THE UNIVERSITY OF NORTH CAROLINA FOUNDATION INC | Raleigh | B99 Education | $17.1M | 7 |
| North Carolina Community Health Center Assoc Inc | Raleigh | E21Z Health Care | $17.1M | 0 |
| GHA AUTISM SUPPORTS | Albemarle | G84Z Diseases, Disorders & Medical Disciplines | $17.1M | 6 |
| LAKE PRINCE CENTER | Newton | L22 Housing & Shelter | $17M | 5 |
| DUKE INTEGRATED NETWORK INC | Durham | E60 Health Care | $16.9M | 12 |
| SOUTHEASTERN COMMUNITY ACTION PARTNERSHIP INC | Lumberton | P99 Human Services | $16.8M | 2 |
| Charlotte Preparatory School Inc | Charlotte | B24 Education | $16.8M | 6 |
| ALAMANCE EXTENDED CARE INC | Greensboro | L22 Housing & Shelter | $16.8M | 7 |
| THE NORTH CAROLINA AQUARIUM SOCIETY | Raleigh | D115 Animal-Related | $16.8M | 4 |
