| BRIDGEWAY ACADEMY | Columbus | P80 Human Services | $13.1M | 2 |
| GRAND AERIE FRATERNAL ORDER OF EAGLES | Grove City | — | $13.1M | 11 |
| LUTHERAN METROPOLITAN MINISTRY | Cleveland | X21 Religion-Related | $13.1M | 3 |
| BEECHWOOD HOME | Cincinnati | E910 Health Care | $13.1M | 7 |
| WOOD LANE RESIDENTIAL SERVICES | Bowling Green | P73Z Human Services | $13.1M | 3 |
| MEDF Physicians Corporation dba Mercer Health Medical Group | Coldwater | E30 Health Care | $13.1M | 43 |
| ORDER OF UNITED COMMERCIAL TRAVELERS OF AMERICA | Columbus | — | $13.1M | 14 |
| WESTERN WATER COMPANY | Morrow | W80Z Public & Societal Benefit | $13.1M | 10 |
| JOHN L SEVERANCE | Brooklyn | A110 Arts, Culture & Humanities | $13M | 1 |
| MENNONITE MEMORIAL HOME | Bluffton | E910 Health Care | $13M | 3 |
| OHIO TRI COUNTY FOOD ALLIANCE DBA SECOND HARVEST FOOD BANK | Springfield | K31 Food, Agriculture & Nutrition | $13M | 1 |
| WILLIAM J AND DOROTHY K O'NEILL FOUNDATION INC | Cleveland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13M | 1 |
| HANCOCK COUNTY SCHOOLS HEALTH | Findlay | — | $13M | 0 |
| STARK COUNTY COMMUNITY ACTION AGENCY | Canton | P20Z Human Services | $13M | 2 |
| GREAT RIVER CONNECTIONS ACADEMY | Columbus | B20 Education | $12.9M | 0 |
| WEST CREEK CONSERVANCY | Parma | C320 Environment | $12.9M | 2 |
| WEXNER FOUNDATION | New Albany | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.8M | 3 |
| ACHIEVEMENT CENTERS FOR CHILDREN | Highland Hills | — | $12.8M | 4 |
| SAMARITAN BEHAVIORAL HEALTH INC | Dayton | E99 Health Care | $12.8M | 13 |
| RONALD MCDONALD HOUSE CHARITIES OF GREATER CINCINNATI INC | Cincinnati | P20Z Human Services | $12.8M | 8 |
| ASHTABULA COUNTY COMMUNITY ACTION AGENCY | Ashtabula | P20Z Human Services | $12.8M | 2 |
| FAMILY HEALTH SERVICES OF ERIE COUNTY | Sandusky | E30 Health Care | $12.8M | 6 |
| THE VAN WERT COUNTY FOUNDATION | Van Wert | — | $12.7M | 3 |
| REGINA HEALTH CENTER | Richfield | E19 Health Care | $12.7M | 2 |
| SAMUEL H & MARIA MILLER FOUNDATION C/O ELEANOR FANSLAU | Cleveland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.7M | 0 |
| NEW LEAF ORGANIZATION | Port Clinton | B20 Education | $12.7M | 0 |
| GREATER DAYTON AREA HOSPITAL ASSOCIATION | Dayton | — | $12.7M | 4 |
| THE CLEVELAND PLAY HOUSE | Cleveland | A65 Arts, Culture & Humanities | $12.6M | 3 |
| The Cincinnati Ballet Company Inc | Cincinnati | A630 Arts, Culture & Humanities | $12.6M | 6 |
| HABITAT FOR HUMANITY - MIDOHIO | Columbus | — | $12.6M | 4 |
| The Veale Foundation | Pepper Pike | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.6M | 0 |
| CARDINAL LAND CONSERVANCY | Loveland | C340 Environment | $12.6M | 3 |
| RICHLAND COUNTY FOUNDATION | Mansfield | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $12.6M | 3 |
| OHIO & ERIE CANALWAY COALITION | Akron | A82Z Arts, Culture & Humanities | $12.6M | 1 |
| THE ARC OF OHIO INC | Columbus | — | $12.5M | 2 |
| MEDICAL EDUCATIONAL AND DEVELOPMENT FOUNDATION | Coldwater | — | $12.5M | 0 |
| LAKEWOOD COUNTRY CLUB COMPANY | Westlake | — | $12.5M | 5 |
| AMERICAN SOCIETY FOR NONDESTRUCTIVE TESTING | Columbus | U034 Science & Technology | $12.5M | 5 |
| COMMUNITY HEALTH PROFESSIONALS INC | Van Wert | E920 Health Care | $12.5M | 16 |
| COMMUNITY HEALTH CENTERS OF GREATER DAYTON | Dayton | E320 Health Care | $12.5M | 7 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF YOUNGSTOWN OHIO INC | Youngstown | P270 Human Services | $12.5M | 1 |
| Bethany House Services Inc | Cincinnati | L41Z Housing & Shelter | $12.4M | 2 |
| PLUMBERS & PIPEFITTERS LOCAL 162 HEALTH & INSURANCE FUND | Dayton | — | $12.4M | 0 |
| HANCOCK-HARDIN-WYANDOT-PUTNAM COMMUNITY ACTION COMMISSION | Findlay | — | $12.4M | 2 |
| SCHONWALD-ROYSE TRUST FUND (FORMERLY KNOWN AS ROYSE SCHONWALD TW) | Brooklyn | B12 Education | $12.4M | 1 |
| BEHAVIORAL HEALTHCARE PARTNERS OF CENTRAL OHIO INC | Newark | F20 Mental Health & Crisis Intervention | $12.4M | 7 |
| THE RESIDENT HOME CORPORATION | Cincinnati | P730 Human Services | $12.4M | 2 |
| Great Western Academy | Columbus | B29 Education | $12.4M | 4 |
| DAYTON REGIONAL STEM SCHOOLS INC | Kettering | B29 Education | $12.3M | 0 |
| COMPDRUG INC | Columbus | — | $12.3M | 10 |
