| THORNWELL | Clinton | P730 Human Services | $13.8M | 7 |
| GREATER LAKE CITY ALLIANCE | Lake City | S20 Community Improvement & Capacity Building | $13.8M | 1 |
| South Carolina Legal Services | Greenville | I80Z Crime & Legal-Related | $13.8M | 8 |
| OCAB Community Action Agency Inc | Orangeburg | S200 Community Improvement & Capacity Building | $13.8M | 1 |
| RIVERBANKS SOCIETY | Columbia | D115 Animal-Related | $13.8M | 0 |
| CAROLINA COMMUNITY ACTIONS INC | Rock Hill | P20Z Human Services | $13.7M | 3 |
| COMMUNITY MEDICINE FOUNDATION INC | Rock Hill | — | $13.6M | 12 |
| Westminster Presbyterian Center Inc | Rock Hill | E91 Health Care | $13.5M | 6 |
| LIBERTY STEAM CHARTER SCHOOL | Sumter | B20 Education | $13.5M | 2 |
| SEA PINES COUNTRY CLUB INC | Hilton Head Island | — | $13.3M | 8 |
| SC Office of Rural Health Inc | Lexington | E21 Health Care | $13.2M | 2 |
| Roper St Francis Foundation | Charleston | E80 Health Care | $13.2M | 10 |
| ONE NATION INNOVATION | Columbia | U05 Science & Technology | $13M | 3 |
| YOUNG MENS CHRISTIAN ASSOCIATION of Greater Spartanburg | Spartanburg | — | $12.9M | 1 |
| SEABROOK OF HILTON HEAD | Hilton Head Island | — | $12.8M | 1 |
| CHANTICLEER ATHLETIC FOUNDATION | Conway | B42I Education | $12.8M | 0 |
| HILTON HEAD CHRISTIAN ACADEMY | Bluffton | B24Z Education | $12.6M | 0 |
| LOWCOUNTRY LAND TRUST INC | Charleston | C340 Environment | $12.6M | 1 |
| HILTON HEAD ISLAND - BLUFFTON CHAMBER OF COMMERCE | Hilton Head Island | — | $12.5M | 5 |
| SOUTHERN CAROLINA REGIONAL DEVELOPMENT ALLIANCE | Barnwell | S41Z Community Improvement & Capacity Building | $12.4M | 3 |
| LEXINGTON RICHLAND ALCOHOL & DRUG ABUSE COUNCIL INC | Columbia | F22Z Mental Health & Crisis Intervention | $12.4M | 2 |
| UNITED WAY OF GREENVILLE COUNTY INC | Greenville | — | $12.2M | 6 |
| RIVERVIEW CHARTER SCHOOL | Beaufort | B24 Education | $12.1M | 1 |
| CHARLESTON ANIMAL SOCIETY | North Charleston | D200 Animal-Related | $11.9M | 6 |
| ALSTON WILKES SOCIETY | Columbia | — | $11.9M | 1 |
| GRAY COLLEGIATE ACADEMY INC | West Columbia | B29 Education | $11.8M | 2 |
| FOOTHILLS COMMUNITY HEALTH CARE INC | Anderson | E30 Health Care | $11.8M | 9 |
| DATAW ISLAND CLUB INC | Beaufort | N50 Recreation & Sports | $11.8M | 4 |
| SOUTH CAROLINA BANKERS EMPLOYEE BENEFIT TRUST | Chapin | — | $11.7M | 1 |
| SOUTH CAROLINA BAR | Columbia | — | $11.7M | 6 |
| PALMETTO DUNES PROPERTY OWNERS ASSOCIATION INC | Hilton Head Island | P20 Human Services | $11.7M | 5 |
| CHARLESTON COUNTY HUMAN SERVICES COMMISSION INC | Charleston | P200 Human Services | $11.6M | 0 |
| THE STATE AGRICULTURAL & MECHANICAL SOCIETY OF SOUTH CAROLINA | Columbia | N520 Recreation & Sports | $11.6M | 11 |
| BREEZY HILL WATER AND SEWER CO | Graniteville | — | $11.6M | 1 |
| BEAUFORT-JASPER EOC INC | Beaufort | — | $11.6M | 0 |
| GUTHRIE RISK RETENTION GROUP | Charleston | F11 Mental Health & Crisis Intervention | $11.5M | 2 |
| THORNBLADE CLUB INC | Greer | — | $11.4M | 5 |
| OLDFIELD CLUB | Okatie | N50 Recreation & Sports | $11.4M | 0 |
| Horry County Disabilities & Special Needs Board | Conway | P820 Human Services | $11.4M | 2 |
| AMERICAN LEPROSY MISSIONS INC | Greenville | Q123 International, Foreign Affairs & National Security | $11.3M | 7 |
| UNITED HOUSING CONNECTIONS | Greenville | S20 Community Improvement & Capacity Building | $11.3M | 0 |
| CHESTERFIELD COUNTY RURAL WATER COMPANY INC | Chesterfield | — | $11.3M | 11 |
| Oconee Medical Holdings | Seneca | E220 Health Care | $11.2M | 0 |
| SPOLETO FESTIVAL USA INC | Charleston | A200 Arts, Culture & Humanities | $11.2M | 7 |
| INTERNATIONAL AFRICAN AMERICAN MUSEUM | Charleston | A50 Arts, Culture & Humanities | $11.2M | 7 |
| SEABROOK ISLAND PROPERTY OWNERS ASSOCIATION | Johns Island | S22 Community Improvement & Capacity Building | $11.1M | 4 |
| PINEWOOD PREPARATORY SCHOOL | Summerville | B24Z Education | $11.1M | 1 |
| CHARLESTON GAILLARD MANAGEMENT CORPORATION | Charleston | A02 Arts, Culture & Humanities | $11M | 2 |
| LOWCOUNTRY AIDS SERVICES CHILDS | Charleston | — | $11M | 1 |
| CAMDEN MILITARY ACADEMY | Camden | B25Z Education | $11M | 1 |
