| UNIVERSITY OF SOUTH CAROLINA BUSINESS PARTNERSHIP FOUNDATION | Columbia | — | $19.4M | 5 |
| SALUDA NURSING CENTER | Saluda | — | $19.3M | 1 |
| PROJECT HOPE FOUNDATION INC | Greenville | P820 Human Services | $19.2M | 2 |
| HERITAGE CLASSIC FOUNDATION | Hilton Head Island | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $19M | 5 |
| PALMETTO GOODWILL SERVICES | North Charleston | J320 Employment | $18.8M | 9 |
| PEE DEE COMMUNITY ACTION PARTNERSHIP INC | Florence | — | $18.8M | 0 |
| Connie Maxwell Children's Ministries | Greenwood | P730 Human Services | $18.8M | 6 |
| HOLLINGSWORTH FUNDS INC | Greenville | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $18.6M | 15 |
| BRIDGES PREPARATORY SCHOOL | Beaufort | B29 Education | $18.6M | 1 |
| SHERMAN COLLEGE OF STRAIGHT CHIROPRACTIC | Spartanburg | B500 Education | $18.6M | 9 |
| ST LUKES FREE MEDICAL CLINIC OF SPARTANBURG INC | Spartanburg | E30Z Health Care | $17.9M | 2 |
| Medical Society of South Carolina | Charleston | E110 Health Care | $17.7M | 2 |
| WATERFRONT EMPLOYERS - ILA WELFARE PL | Charleston | — | $17.6M | 3 |
| SOUTH CAROLINA CHRISTIAN FOUNDATION | Spartanburg | X20 Religion-Related | $17.5M | 1 |
| ST JOHN'S WATER COMPANY INC | Johns Island | — | $17.5M | 0 |
| HORSE CREEK ACADEMY | Aiken | B29 Education | $17.4M | 2 |
| ROAD2HIRE | Fort Mill | B30 Education | $17.2M | 0 |
| HIGH POINT ACADEMY INC | Spartanburg | B29 Education | $16.9M | 1 |
| WACCAMAW ECONOMIC OPPORTUNITY INC | Conway | S200 Community Improvement & Capacity Building | $16.9M | 2 |
| BLUE RIDGE RURAL WATER CO INC | Greer | — | $16.8M | 1 |
| MCLEOD HEALTH FOUNDATION | Florence | E22I Health Care | $16.7M | 2 |
| Community Foundation of the Lowcountry | Hilton Head Island | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $16.7M | 3 |
| BERKELEY CITIZENS INC | Moncks Corner | P82Z Human Services | $16.6M | 1 |
| BUILDING EQUITY SOONER FOR TOMORROW | Greenville | B11 Education | $16.5M | 2 |
| EPWORTH CHILDREN'S HOME | Columbia | P70 Human Services | $16.4M | 7 |
| SOUTH CAROLINA RESEARCH AUTHORITY | Columbia | U40 Science & Technology | $16.2M | 10 |
| St Josephs Catholic School Inc | Greenville | — | $16.2M | 4 |
| BROOKGREEN GARDENS | Pawleys Island | C410 Environment | $16M | 2 |
| Municipal Association of South Carolina | Columbia | — | $15.6M | 12 |
| NATIONAL WILD TURKEY FEDERATION INC | Edgefield | C300 Environment | $15.3M | 0 |
| SOUTH CAROLINA AUTOMOBILE DEALERS EMPLOYEE BENEFIT TRUST | Columbia | — | $15.1M | 0 |
| GEORGETOWN KRAFT CREDIT UNION | Georgetown | — | $15M | 3 |
| United Methodist Manor of the Pee Dee | Florence | P110 Human Services | $15M | 3 |
| SPRING ISLAND CLUB | Okatie | N6A Recreation & Sports | $14.7M | 12 |
| GAMECOCK CLUB OF THE UNIVERSITY OF SOUTH CAROLINA | Columbia | — | $14.6M | 1 |
| PEE DEE MEDICAL AND HEALTH SCIENCES EDUCATION CONSORTIUM | Florence | B99 Education | $14.6M | 1 |
| VISITGREENVILLESC | Greenville | — | $14.6M | 4 |
| TMPC Nonprofit Holdings Inc | Columbia | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $14.4M | 0 |
| SPARTANBURG DAY SCHOOL | Spartanburg | — | $14.4M | 5 |
| SPARTANBURG ACADEMIC MOVEMENT | Spartanburg | B90 Education | $14.4M | 1 |
| GBSC FOUNDATION | Charleston | N31 Recreation & Sports | $14.3M | 0 |
| Medical Services of America Inc Employee Health Benefit Plan Trust | Lexington | — | $14.2M | 0 |
| ELECTRIC COOPERATIVES OF SOUTH CAROLINA | Cayce | — | $14.2M | 6 |
| HOSPICE OF THE UPSTATE INC | Anderson | — | $14.1M | 1 |
| NATIONAL HONORARY BETA CLUB | Spartanburg | O50Z Youth Development | $14.1M | 21 |
| UNITED WAY OF THE MIDLANDS | Columbia | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $14.1M | 6 |
| ETV Endowment of South Carolina Inc | Spartanburg | A120 Arts, Culture & Humanities | $14M | 2 |
| ONE-EIGHTY PLACE | Charleston | L410 Housing & Shelter | $14M | 6 |
| EASTERN CAROLINA HOMELESSNESS ORG INC ECHO | Myrtle Beach | L41 Housing & Shelter | $13.9M | 2 |
| FOREST LAKE CLUB | Columbia | N50 Recreation & Sports | $13.8M | 1 |
