| GOLDEN TRIANGLE PLANNING | Starkville | — | $10M | 6 |
| COMMUNITY HEALTH CENTER ASSOC OF MS | Jackson | E02 Health Care | $9.9M | 3 |
| CONVERGE INC | Ridgeland | E60 Health Care | $9.8M | 3 |
| MISSISSIPPI HIGHER EDUCATION ASSISTANCE | Jackson | W60 Public & Societal Benefit | $9.8M | 3 |
| OKTIBBEHA EDUCATIONAL FOUNDATION | Starkville | — | $9.7M | 1 |
| GREENWOOD LEFLORE EDUCATIONAL FOUND | Greenwood | B21Z Education | $9.6M | 1 |
| MISSISSIPPI HOSPITAL ASSOCIATION | Madison | — | $9.2M | 8 |
| Dr Arenia C Mallory Community Health Center Inc | Lexington | — | $9M | 7 |
| UNITED METHODIST SENIOR SERVICES OF | Tupelo | E910 Health Care | $9M | 7 |
| Jefferson Comprehensive Health Center | Fayette | E32Z Health Care | $9M | 9 |
| ELECTRIC COOPERATIVES OF | Ridgeland | — | $9M | 5 |
| MISSISSIPPI PUBLIC HEALTH INSTITUTE | Madison | E99 Health Care | $8.9M | 4 |
| South Central Community Action Agency Inc | Jackson | P20 Human Services | $8.8M | 2 |
| MR & MRS E H SUMNERS FOUNDATION | Ridgeland | B120 Education | $8.8M | 1 |
| Greater Meridian Health Clinic Inc | Meridian | E320 Health Care | $8.8M | 9 |
| MISSISSIPPI AQUARIUM | Gulfport | D50 Animal-Related | $8.7M | 4 |
| BAPTIST HOMES INC | Ridgeland | P73 Human Services | $8.7M | 6 |
| THE BOWER FOUNDATION | Ridgeland | G440 Diseases, Disorders & Medical Disciplines | $8.6M | 6 |
| LARRY WIGGERS OVERBY FOUNDATION | Brandon | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.5M | 0 |
| NORTH DELTA PLANNING AND DEV DIST | Batesville | W20 Public & Societal Benefit | $8.4M | 2 |
| UNIVERSITY OF MISSISSIPPI | University | B190 Education | $8.4M | 4 |
| BAPTIST MEDICAL & DENTAL MISSION | Hattiesburg | Q300 International, Foreign Affairs & National Security | $8.4M | 3 |
| Coahoma Opportunities Inc | Clarksdale | — | $8.4M | 5 |
| INTERNATIONAL BROTHERHOOD OF | Byram | — | $8.4M | 5 |
| BOLIVAR MEDICAL CENTER FOUNDATION | Cleveland | E11 Health Care | $8.3M | 0 |
| Warren-Washington-Issaquena-Sharkey Community Action Agency | Greenville | — | $8.3M | 3 |
| NORTHEAST MS COMMUNITY SVCS INC | Booneville | P200 Human Services | $8.2M | 2 |
| COMMUNITY PLACE | Brandon | E22Z Health Care | $8.2M | 0 |
| My Brother's Keeper Inc | Ridgeland | G058 Diseases, Disorders & Medical Disciplines | $8.1M | 5 |
| MARTHA COKER HOME INC | Tupelo | E91 Health Care | $8M | 6 |
| NORTHEAST MISSISSIPPI PLANNING AND DEVELOPMENT DIS | Booneville | S200 Community Improvement & Capacity Building | $8M | 2 |
| EAST CENTRAL PLANNING AND | Newton | — | $7.9M | 4 |
| MISSISSIPPI UNIVERSITY FOR WOMEN | Columbus | — | $7.9M | 1 |
| DELTA REGIONAL FOUNDATION INC | Olive Branch | P20 Human Services | $7.8M | 1 |
| FRIENDS OF THE RUSSELL C DAVIS | Jackson | U99 Science & Technology | $7.7M | 0 |
| MIDTOWN PARTNERS INC | Jackson | P20Z Human Services | $7.7M | 1 |
| CATHOLIC CHARITIES INC | Jackson | P20Z Human Services | $7.6M | 6 |
| Multi-County Community Service Agency Inc | Meridian | P200 Human Services | $7.6M | 3 |
| NORTHEAST MISSISSIPPI HEALTH CARE INC | Byhalia | E300 Health Care | $7.5M | 8 |
| MANTACHIE RURAL HEALTH CARE INC | Mantachie | — | $7.4M | 9 |
| CLARKSDALE COLLEGIATE PUBLIC | Clarksdale | B29 Education | $7.4M | 1 |
| THE SANCTUARY HOSPICE HOUSE INC | Tupelo | P74 Human Services | $7.4M | 3 |
| MADDOX FOUNDATION | Hernando | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $7.3M | 4 |
| EIGHT DAYS OF HOPE INC | Tupelo | L81 Housing & Shelter | $7.3M | 1 |
| SR1 | Ridgeland | V23 Social Science | $7.3M | 1 |
| DUGAN MEMORIAL HOME INC | Tupelo | E91 Health Care | $7.3M | 6 |
| UNIVERSITY OF SOUTHERN MISSISSIPPI | Hattiesburg | B99 Education | $7.2M | 2 |
| PIKE SCHOOL CORPORATION INC | McComb | B20 Education | $7.1M | 1 |
| AMITE COUNTY MEDICAL SERVICES INC | Liberty | E300 Health Care | $7.1M | 8 |
| LAMAR SCHOOL FOUNDATION | Meridian | B24 Education | $7M | 0 |
