| OZARK TRAILS COUNCIL | Springfield | — | $2.6M | 1 |
| Applied Scholastics International | Saint Louis | B00B Education | $2.6M | 2 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION | Hannibal | P270 Human Services | $2.6M | 1 |
| KIDS HARBOR INC | Osage Beach | P43 Human Services | $2.6M | 1 |
| UNITED WE | Kansas City | Z99Z Unknown | $2.6M | 2 |
| WARRENSBURG CHRISTIAN SCHOOL | Warrensburg | B24 Education | $2.6M | 3 |
| JOPLIN FAMILY Y | Joplin | P270 Human Services | $2.6M | 0 |
| RICHARD J STERN FOUNDATION FOR THE ARTS | Kansas City | — | $2.6M | 3 |
| CITY OF REFUGE | Columbia | P40 Human Services | $2.6M | 1 |
| BOTANICAL SOCIETY OF AMERICA INC | St Louis | C420 Environment | $2.6M | 1 |
| SOUTHWEST MISSOURI COMMUNITY ALLIAN | Joplin | N20 Recreation & Sports | $2.6M | 0 |
| CHILD ABUSE PREVENTION ASSOCIATION | Independence | — | $2.6M | 2 |
| LAKEWOOD HOLDING COMPANY INC | Lees Summit | N60 Recreation & Sports | $2.6M | 0 |
| DEAF EMPOWERMENT AWARENESS FOUNDATION | Saint Louis | P87 Human Services | $2.6M | 1 |
| BOYS AND GIRLS CLUB OF THE OZARKS | Branson | O23 Youth Development | $2.6M | 1 |
| ST LOUIS TEACHER RESIDENCY | Saint Louis | B50 Education | $2.6M | 2 |
| LABORERS INTERNATIONAL UNION OF 660 | St Charles | — | $2.6M | 4 |
| THE BICKNELL FAMILY FOUNDATION | Kansas City | P110 Human Services | $2.6M | 0 |
| GIRL SCOUTS OF EASTERN MO TR | Clayton | O420 Youth Development | $2.6M | 1 |
| Musgrave Foundation | Springfield | — | $2.6M | 0 |
| SPRINKLER FITTERS LOCAL NO 268 | St Louis | — | $2.6M | 3 |
| REBUILDING TOGETHER - ST LOUIS | St Louis | S25Z Community Improvement & Capacity Building | $2.6M | 1 |
| SANDAGER BRIGITTE CHARITABLE TR | Saint Louis | — | $2.5M | 1 |
| MISSOURI LIFE AND HEALTH INSURANCE | Jefferson City | — | $2.5M | 2 |
| SERVE INC | Fulton | P200 Human Services | $2.5M | 0 |
| GRAYBAR FOUNDATION | Clayton | — | $2.5M | 0 |
| ACCESS II - INDEPENDENT LIVING CENTER | Gallatin | P82 Human Services | $2.5M | 0 |
| Sam B Cook Foundation | Jefferson City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 0 |
| ASBESTOS WORKERS LOCAL 1 VACATION TRUST | St Louis | — | $2.5M | 0 |
| RAINBOW VILLAGE PROPERTIES INC | St Louis | P73 Human Services | $2.5M | 1 |
| EYE THRIVE | St Louis | P30 Human Services | $2.5M | 1 |
| MEADOW LAKE ACRES COUNTRY CLUB | New Bloomfield | — | $2.5M | 0 |
| SNI GLOBAL | Jefferson City | K03 Food, Agriculture & Nutrition | $2.5M | 2 |
| CHILDREN OF MEXICO INC | Union | Q330 International, Foreign Affairs & National Security | $2.5M | 1 |
| LAKESIDE CENTER PUBLIC IMPROVEMENT | Columbia | — | $2.5M | 0 |
| UNLOCKED LABS | Saint Louis | I02 Crime & Legal-Related | $2.5M | 2 |
| Laurie Foundation for the Performing Arts | Columbia | A63 Arts, Culture & Humanities | $2.5M | 0 |
| VASCULITIS FOUNDATION | Kansas City | — | $2.5M | 1 |
| INTERNATIONAL ASSOCIATION OF HEAT & | Independence | — | $2.5M | 11 |
| FOOTPRINTS INC | Kansas City | F21 Mental Health & Crisis Intervention | $2.5M | 3 |
| A J SCHWARTZE COMMUNITY FOUNDATION | Jefferson City | — | $2.5M | 3 |
| THE COVERING HOUSE | Saint Louis | P62 Human Services | $2.5M | 1 |
| KANSAS CITY METROPOLITAN CRIME | Kansas City | — | $2.5M | 2 |
| SUNNEN FOUNDATION | St Louis | — | $2.5M | 0 |
| THE SOULFISHER MINISTRIES | Saint Louis | B80 Education | $2.5M | 3 |
| CARING COMMUNITIES INC | Jefferson City | P20 Human Services | $2.5M | 1 |
| NATIONAL MUSEUM OF TOYS AND MINIATURES | Kansas City | A50 Arts, Culture & Humanities | $2.5M | 1 |
| Safe and Sound A Sandy Hook Initiative Inc | Joplin | I20 Crime & Legal-Related | $2.5M | 2 |
| ST FRANCIS COMMUNITY SERVICES | St Louis | — | $2.5M | 4 |
| ALLIANCE FOR LIFE - MISSOURI INC | Lees Summit | R02 Civil Rights, Social Action & Advocacy | $2.5M | 0 |
