| Baptist Healthcare System Inc | Louisville | E210 Health Care | $4.3B | 24 |
| Norton Hospitals Inc | Louisville | E220 Health Care | $3B | 15 |
| St Elizabeth Medical Center Inc | Edgewood | E220 Health Care | $1.9B | 35 |
| U OF L HEALTH - LOUISVILLE INC | Louisville | E22 Health Care | $1.2B | 24 |
| East Kentucky Power Cooperative Inc | Winchester | — | $1.2B | 32 |
| SAINT JOSEPH HEALTH SYSTEM INC | Lexington | E220 Health Care | $911.3M | 15 |
| Owensboro Health Inc | Owensboro | E210 Health Care | $888.7M | 28 |
| APPALACHIAN REGIONAL HEALTHCARE | Lexington | E210 Health Care | $882.9M | 12 |
| UNIVERSITY MEDICAL CENTER INC | Louisville | E220 Health Care | $881.9M | 28 |
| Baptist Health Medical Group Inc | Louisville | E30 Health Care | $850.8M | 11 |
| Adam R Scripps Foundation | Ft Mitchell | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $767.2M | 1 |
| ASHLAND HOSPITAL CORPORATION | Ashland | E220 Health Care | $762.4M | 16 |
| COMMUNITY MEDICAL ASSOCIATES INC | Louisville | E30 Health Care | $730.3M | 9 |
| PIKEVILLE MEDICAL CENTER INC | Pikeville | E220 Health Care | $688.9M | 29 |
| BOWLING GREEN WARREN COUNTY COMMUNITY HOSPITAL CORPORATION | Bowling Green | E220 Health Care | $637.7M | 14 |
| University of Louisville Research Foundation | Louisville | B050 Education | $631.9M | 11 |
| Norton Healthcare Inc | Louisville | E210 Health Care | $607.1M | 39 |
| Summit Medical Group Inc | Erlanger | E20Z Health Care | $548.3M | 28 |
| THE GEORGE AND BEVERLY RAWLINGS | LaGrange | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $543.7M | 0 |
| UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | Lexington | B110 Education | $463M | 8 |
| KENTUCKY MEDICAL SERVICES FOUNDATION | Lexington | B110 Education | $386.2M | 36 |
| UNIVERSITY OF LOUISVILLE PHYSICIANS INC | Louisville | E300 Health Care | $354M | 32 |
| KENERGY CORP | Henderson | — | $347.3M | 23 |
| Baptist Health Deaconess Madisonville | Madisonville | E220 Health Care | $289.6M | 8 |
| TJ SAMSON COMMUNITY HOSPITAL | Glasgow | E220 Health Care | $259.3M | 11 |
| EPHRAIM MCDOWELL REGIONAL MEDICAL CENTER | Danville | E22Z Health Care | $257.2M | 15 |
| WARREN RURAL ELECTRIC COOPERATIVE | Bowling Green | — | $241.4M | 17 |
| OWEN ELECTRIC COOPERATIVE INC | Owenton | — | $237.8M | 19 |
| CHRISTIAN APPALACHIAN PROJECT INC | Paintsville | P200 Human Services | $224.3M | 10 |
| ARH TUG VALLEY HEALTH SERVICES INC | Lexington | E22 Health Care | $213.4M | 8 |
| ST CLAIRE MEDICAL CENTER INC | Morehead | E22 Health Care | $210.7M | 15 |
| Jennie Stuart Medical Center Inc | Hopkinsville | E220 Health Care | $199.1M | 8 |
| DELTA DENTAL OF KENTUCKY INC | Louisville | — | $182.1M | 28 |
| UNIVERSITY OF THE CUMBERLANDS INC | Williamsburg | B430 Education | $177.5M | 6 |
| Disabled American Veterans | Erlanger | — | $176.5M | 10 |
| METHODIST HEALTH INC | Henderson | E220 Health Care | $171.1M | 15 |
| COMMONWEALTH CREDIT UNION | Frankfort | — | $159.5M | 14 |
| BEREA COLLEGE | Berea | B420 Education | $157.5M | 17 |
| SOUTH KENTUCKY RURAL ELECTRIC | Somerset | — | $153.5M | 18 |
| BLUE GRASS ENERGY COOPERATIVE CORP | Nicholasville | Y22 Mutual & Membership Benefit | $151.9M | 16 |
| PENNYRILE RURAL ELECTRIC COOPERATIVE CORPORATION | Hopkinsville | — | $151.2M | 15 |
| BELLARMINE UNIVERSITY INCORPORATED | Louisville | B430 Education | $147.9M | 13 |
| COMMONWEALTH HEALTH CORPORATION INC | Bowling Green | E21 Health Care | $146.1M | 12 |
| THE COMMUNITY FOUNDATION OF | Louisville | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $143.7M | 8 |
| GOODWILL INDUSTRIES OF KENTUCKY INC | Louisville | J320 Employment | $138.3M | 10 |
| University of Louisville Athletic Association | Louisville | N030 Recreation & Sports | $137M | 28 |
| SALT RIVER ELECTRIC COOPERATIVE | Bardstown | — | $134.7M | 12 |
| CAMPBELLSVILLE UNIVERSITY INC | Campbellsville | B420 Education | $133.1M | 16 |
| MOUNTAIN COMPREHENSIVE CARE CENTER INC | Prestonsburg | F22Z Mental Health & Crisis Intervention | $123.6M | 7 |
| JACKSON ENERGY COOPERATIVE | McKee | — | $123M | 15 |
