| Northwestern Memorial HealthCare Group | Chicago | E22 Health Care | $10.1B | 52 |
| ADVOCATE HEALTH AND HOSPITALS CORP | Oak Brook | E210 Health Care | $7.8B | 38 |
| CENTRAL STATES SOUTHEAST & SOUTHWEST AREAS HEALTH & WELFARE FUND | Chicago | — | $5.5B | 15 |
| Feeding America | Chicago | K310 Food, Agriculture & Nutrition | $5B | 21 |
| UNIVERSITY OF CHICAGO | Chicago | B430 Education | $4.9B | 31 |
| Northwestern University | Evanston | N500 Recreation & Sports | $4.2B | 37 |
| OSF Healthcare System | Peoria | E220 Health Care | $3.9B | 50 |
| University of Chicago Medical Center | Chicago | E220 Health Care | $3.2B | 38 |
| Rush University Medical Center | Chicago | E22 Health Care | $3B | 52 |
| The Chicago Community Trust | Chicago | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5B | 11 |
| Endeavor Health Clinical Operations | Arlington Heights | E220 Health Care | $2.3B | 40 |
| Northwestern Memorial HealthCare | Chicago | E22 Health Care | $2.3B | 0 |
| MODERN WOODMEN OF AMERICA | Rock Island | — | $2B | 28 |
| LOYOLA UNIVERSITY MEDICAL CENTER | Maywood | E220 Health Care | $1.7B | 17 |
| MEMORIAL HEALTH SYSTEM GROUP | Springfield | — | $1.6B | 39 |
| Ann & Robert H Lurie Children's Hospital of Chicago | Chicago | E24Z Health Care | $1.5B | 16 |
| THE CARLE FOUNDATION HOSPITAL | Urbana | E220 Health Care | $1.4B | 26 |
| UNITE HERE HEALTH | Aurora | — | $1.3B | 9 |
| Alliant Credit Union | Chicago | W61 Public & Societal Benefit | $1.3B | 20 |
| ADVOCATE NORTH SIDE HEALTH NETWORK | Oak Brook | E220 Health Care | $1.2B | 29 |
| LINE CONSTRUCTION BENEFIT FUND | Lombard | — | $1.2B | 16 |
| LOYOLA UNIVERSITY OF CHICAGO | Chicago | B430 Education | $1.1B | 29 |
| DELTA DENTAL OF ILLINOIS | Naperville | — | $1B | 26 |
| THE BIG TEN CONFERENCE INC | Rosemont | — | $928.1M | 26 |
| DEPAUL UNIVERSITY | Chicago | B430 Education | $918.1M | 36 |
| Edward Hospital | Arlington Heights | E220 Health Care | $908.3M | 30 |
| ACCENTURE UNITED STATES BENEFIT TRUST | Chicago | Y43 Mutual & Membership Benefit | $901.3M | 1 |
| JOHN D AND CATHERINE T MACARTHUR FOUNDATION | Chicago | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $890.9M | 20 |
| SwedishAmerican Hospital | Rockford | E220 Health Care | $888.1M | 20 |
| Paul M Angell Family Foundation | Chicago | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $867M | 1 |
| BLUE CROSS BLUE SHIELD ASSOCIATION | Chicago | E80 Health Care | $862.7M | 43 |
| MIDWEST OPERATING ENGINEERS WELFARE FUND | Countryside | — | $758.9M | 11 |
| Fermi Research Alliance LLC | Batavia | U02 Science & Technology | $715.5M | 38 |
| ULSE INC | Evanston | W90 Public & Societal Benefit | $709.4M | 26 |
| Southern Illinois Hospital Services | Carbondale | E220 Health Care | $707.2M | 30 |
| BLESSING HOSPITAL | Quincy | E220 Health Care | $704.7M | 17 |
| University of Illinois Foundation | Champaign | B110 Education | $671.3M | 17 |
| Endeavor Health Medical Group | Arlington Heights | E110 Health Care | $658M | 23 |
| ADVOCATE CONDELL MEDICAL CENTER | Oak Brook | E22 Health Care | $643.1M | 35 |
| Elmhurst Memorial Healthcare Group | Elmhurst | — | $640.9M | 38 |
| Northwest Community Hospital | Arlington Heights | E220 Health Care | $633.8M | 14 |
| SARAH BUSH LINCOLN HEALTH CENTER | Mattoon | E220 Health Care | $626.2M | 20 |
| St John's Hospital of the Hospital Sisters of the Third Order of St Francis | Springfield | E220 Health Care | $601.6M | 9 |
| Silver Cross Hospital and Medical Centers | New Lenox | E220 Health Care | $587.8M | 8 |
| Hospital Sisters Health System | Springfield | E210 Health Care | $577.8M | 11 |
| The Carle Foundation | Urbana | E210 Health Care | $575.4M | 19 |
| ADVENTIST MIDWEST HEALTH | Hinsdale | E220 Health Care | $574.7M | 17 |
| ADVOCATE SHERMAN HOSPITAL | Oak Brook | E220 Health Care | $561.7M | 47 |
| MIDWEST FOOD BANK NFP | Normal | P99 Human Services | $556.7M | 5 |
| AMERICAN MEDICAL ASSOCIATION | Chicago | — | $546.2M | 40 |
