| BJC HEALTH SYSTEM GROUP RETURN | St Louis | E21 Health Care | $6.7B | 56 |
| GOVERNMENT EMPLOYEES HEALTH ASSOCIATION INC | Lees Summit | — | $5.7B | 39 |
| WASHINGTON UNIVERSITY | Saint Louis | B430 Education | $5.2B | 37 |
| ASCENSION SETON | St Louis | — | $3.3B | 19 |
| Ascension Health Alliance | St Louis | — | $2.4B | 16 |
| SSM HEALTH CARE ST LOUIS | St Louis | E210 Health Care | $2.2B | 25 |
| The Children's Mercy Hospital | Kansas City | E240 Health Care | $2.1B | 20 |
| MERCY HOSPITALS EAST COMMUNITIES | St Louis | E220 Health Care | $1.9B | 24 |
| LESTER E COX MEDICAL CENTERS | Springfield | E220 Health Care | $1.8B | 18 |
| Sacred Heart Health System Inc | St Louis | E22Z Health Care | $1.7B | 24 |
| BJC HEALTH SYSTEM DBA BJC HEALTHCARE | St Louis | E210 Health Care | $1.6B | 4 |
| MHM Support Services | Chesterfield | — | $1.5B | 24 |
| ST VINCENT HOSPITAL AND HEALTH CARE CENTER INC | St Louis | E220 Health Care | $1.5B | 16 |
| SSM HEALTH CARE CORPORATION | St Louis | E210 Health Care | $1.4B | 20 |
| MERCY HOSPITAL SPRINGFIELD | Springfield | E220 Health Care | $1.3B | 14 |
| Ascension Health-IS Inc | St Louis | — | $1.3B | 10 |
| Saint Thomas West Hospital | St Louis | E220 Health Care | $1.3B | 18 |
| Presence Chicago Hospitals Network | St Louis | P750 Human Services | $1.2B | 6 |
| St Lukes Hospital of Kansas City | Kansas City | E21 Health Care | $1.2B | 24 |
| ASCENSION ST JOHN HOSPITAL | St Louis | E220 Health Care | $1.1B | 14 |
| SSM HEALTH CARE OF OKLAHOMA INC | St Louis | E220 Health Care | $1.1B | 22 |
| ASCENSION PROVIDENCE HOSPITAL | St Louis | E22 Health Care | $896.9M | 15 |
| ST LOUIS UNIVERSITY | St Louis | B430 Education | $864.3M | 23 |
| SSM-SLUH INC | St Louis | — | $855.9M | 19 |
| TRUMAN MEDICAL CENTER INCORPORATED | Kansas City | E220 Health Care | $835.9M | 9 |
| Presence Central and Suburban Hospitals Network | St Louis | E200 Health Care | $807.2M | 7 |
| Heartland Regional Medical Center | St Joseph | E220 Health Care | $782.2M | 17 |
| SSM HEALTH CARE OF WISCONSIN INC | St Louis | E200 Health Care | $770.2M | 27 |
| ASCENSION VIA CHRISTI HOSPITALS WICHITA INC | St Louis | E220 Health Care | $759.1M | 15 |
| Greater Horizons | Kansas City | T113 Philanthropy, Voluntarism & Grantmaking Foundations | $754.1M | 2 |
| MERCY CLINIC EAST COMMUNITIES | Chesterfield | Z99 Unknown | $739.7M | 49 |
| Delta Dental of Missouri | St Louis | — | $724.1M | 30 |
| SAINT FRANCIS MEDICAL CENTER | Cape Girardeau | E220 Health Care | $695.1M | 25 |
| ST MARY'S HEALTH INC | St Louis | E220 Health Care | $689.6M | 14 |
| FREEMAN HEALTH SYSTEM | Joplin | E220 Health Care | $669.2M | 17 |
| ST LUKES EPISCOPAL-PRESBYTERIAN HOSPITALS | Chesterfield | E220 Health Care | $664.6M | 24 |
| COLUMBIA ST MARY'S HOSPITAL MILWAUKEE INC | St Louis | E220 Health Care | $662.4M | 15 |
| MERCY HOSPITAL SOUTH | St Louis | E220 Health Care | $661.3M | 15 |
| St John Medical Center Inc | St Louis | E220 Health Care | $600.4M | 18 |
| MERCY CLINIC SPRINGFIELD COMMUNITIES | Springfield | E320 Health Care | $562.9M | 27 |
| Saint Lukes Physician Group Inc | Kansas City | E21 Health Care | $562.5M | 19 |
| COMPASS HEALTH INC | Clinton | F30Z Mental Health & Crisis Intervention | $557.2M | 12 |
| Saint Thomas Rutherford Hospital | St Louis | E220 Health Care | $512.9M | 18 |
| St Agnes Healthcare Inc | St Louis | E220 Health Care | $494.2M | 14 |
| Alexian Brothers Medical Center | St Louis | E220 Health Care | $482M | 9 |
| Greater Kansas City Community Foundation | Kansas City | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $462.1M | 8 |
| St Vincent's Medical Center Inc | St Louis | — | $453.8M | 16 |
| ASCENSION MACOMB OAKLAND HOSPITAL | St Louis | E220 Health Care | $453.2M | 16 |
| CH ALLIED SERVICES INC | Columbia | E200 Health Care | $438.3M | 16 |
| SSM CARDINAL GLENNON CHILDREN'S HOSPITAL | St Louis | E240 Health Care | $432.5M | 19 |
