| GREENVILLE TECHNICAL CHARTER HIGH SCHOOL | Greenville | B25 Education | $7M | 0 |
| GREENVILLE FREE MEDICAL CLINIC INC | Greenville | — | $7M | 1 |
| DARLINGTON COUNTY COMMUNITY ACTION | Hartsville | P20 Human Services | $7M | 0 |
| HOME BUILDERS ASSOCIATION OF SOUTH CAROLINA GROUP TRUST INSURANCE | Columbia | Y20 Mutual & Membership Benefit | $6.9M | 0 |
| South Carolina Community Loan Fund | Charleston | L99 Housing & Shelter | $6.9M | 5 |
| CURIS FINANCIAL CREDIT UNION | Columbia | — | $6.9M | 1 |
| River Hills Country Club Inc | Lake Wylie | — | $6.9M | 2 |
| CLINTON COLLEGE | Rock Hill | B41Z Education | $6.9M | 5 |
| HILTON HEAD REGIONAL HABITAT FOR HUMANITY INC | Bluffton | L210 Housing & Shelter | $6.8M | 1 |
| COMMUNITYWORKS INC | Greenville | L82 Housing & Shelter | $6.8M | 1 |
| TRI-COUNTY TECHNICAL COLLEGE FOUNDATION INC | Pendleton | B43I Education | $6.8M | 0 |
| MASON PREPARATORY SCHOOL | Charleston | B24Z Education | $6.8M | 3 |
| CAMPBELL YOUNG LEADERS | Greenville | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $6.8M | 1 |
| CONGRESSIONAL MEDAL OF HONOR SOCIETY OF THE UNITED STATES OF | Mount Pleasant | W30 Public & Societal Benefit | $6.7M | 5 |
| AIKEN HORSE PARK FOUNDATION | Aiken | D99 Animal-Related | $6.7M | 1 |
| WILLIAMSBURG REGIONAL HOSPITAL | Kingstree | E22 Health Care | $6.7M | 4 |
| SECOND HELPINGS | Hilton Head Island | P99Z Human Services | $6.7M | 0 |
| INSTITUTE FOR CHILD SUCCESS INC | Greenville | V23 Social Science | $6.7M | 8 |
| CLEAR DOT CHARTER SCHOOL COLUMBIA INC | Columbia | B29 Education | $6.7M | 1 |
| NATIONAL EDUCATIONAL TELECOMMUNICATIONS | Columbia | A320 Arts, Culture & Humanities | $6.7M | 7 |
| University of South Carolina Alumni Association | Columbia | B84Z Education | $6.7M | 5 |
| NCEES FOUNDATION | Greenville | U42 Science & Technology | $6.6M | 3 |
| SOUTH CAROLINA HIGH SCHOOL LEAGUE | Columbia | — | $6.6M | 4 |
| The Country Club of Spartanburg | Spartanburg | N51Z Recreation & Sports | $6.6M | 4 |
| SOUTHEAST COASTAL OCEAN OBSERVING REGIONAL ASSOCIATION | Charleston | S40 Community Improvement & Capacity Building | $6.6M | 1 |
| SOUTH CAROLINA SCHOOL BOARDS ASSOCIATION INC | Columbia | B11 Education | $6.6M | 6 |
| UNITED WAY ASSOCIATION OF SOUTH CAROLINA INC | Columbia | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $6.5M | 1 |
| South Carolina Educational Credit for Exceptional Needs Children Fund | Columbia | B82 Education | $6.5M | 0 |
| PRIMARY CARE ASSOCIATION OF SC INC | Columbia | E21Z Health Care | $6.5M | 5 |
| ORANGEBURG CONSOLIDATED SCHOOL DISTICT 5 HIGH SCHOOL FOR HEALTH PROFESSIONS | Orangeburg | B29 Education | $6.4M | 1 |
| BRIGHTER FUTURE EMPLOYMENT SERVICES | Columbia | J99 Employment | $6.4M | 3 |
| BEAUFORT MEMORIAL HOSPITAL FOUNDATION | Beaufort | E22I Health Care | $6.4M | 0 |
| ONESPARTANBURG INC FOUNDATION | Spartanburg | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $6.4M | 0 |
| CULTURAL AND HERITAGE COMMISSION | Rock Hill | A500 Arts, Culture & Humanities | $6.4M | 1 |
| CLEMSON UNIVERSITY LAND STEWARDSHIP FOUNDATION INC | Clemson | B11 Education | $6.3M | 0 |
| WACHESAW PLANTATION CLUB INC | Murrells Inlet | — | $6.3M | 0 |
| Oliver Gospel Mission | Columbia | X20 Religion-Related | $6.3M | 5 |
| SPARTANBURG COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $6.3M | 0 |
| MEYER CENTER FOR SPECIAL CHILDREN | Greenville | — | $6.3M | 1 |
| BRASHIER MIDDLE COLLEGE CHARTER HIGH SCHOOL INC | Simpsonville | B29 Education | $6.2M | 0 |
| KERSHAW COUNTY COMMISSION ON ALCOHO DRUG ABUSE | Camden | F20Z Mental Health & Crisis Intervention | $6.2M | 1 |
| Senior Resources Inc | Columbia | P81Z Human Services | $6.2M | 2 |
| DEE NORTON LOWCOUNTRY CHILDREN'S CENTER | Charleston | — | $6.2M | 5 |
| KUZNIK CHARITABLE FOUNDATION | Charleston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $6.2M | 6 |
| SPECIALIZED ALTERNATIVES FOR FAMILIES & YOUTH OF SOUTH CAROLINA INC | Columbia | I20Z Crime & Legal-Related | $6.2M | 5 |
| YORK COUNTY COUNCIL ON ALCOHOL AND DRUG ABUSE INC | Rock Hill | — | $6.2M | 3 |
| MIRASOL HEALTH INC | Bluffton | — | $6.2M | 6 |
| CENTER FOR HEIRS' PROPERTY PRESERVATION | North Charleston | I80 Crime & Legal-Related | $6.2M | 4 |
| KIDS UPSTATE | Spartanburg | O23 Youth Development | $6.1M | 1 |
| OCONEE MEMORIAL HOSPITAL FOUNDATION INC | Seneca | E112 Health Care | $6.1M | 0 |
