| YORK COUNTY COUNCIL ON ALCOHOL AND | Rock Hill | — | $6.3M | 3 |
| MEYER CENTER FOR SPECIAL CHILDREN | Greenville | — | $6.3M | 1 |
| THE ROBERTS FOUNDATION FOUNDED BY | Charleston | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $6.3M | 3 |
| River Hills Country Club Inc | Lake Wylie | — | $6.3M | 2 |
| KERSHAW COUNTY COMMISSION ON ALCOHO | Camden | F20Z Mental Health & Crisis Intervention | $6.2M | 1 |
| Senior Resources Inc | Columbia | P81Z Human Services | $6.2M | 2 |
| FIRST PRESBYTERIAN ACADEMY INC | Greenville | B24 Education | $6.2M | 2 |
| DEE NORTON LOWCOUNTRY CHILDREN'S CENTER | Charleston | — | $6.2M | 5 |
| KUZNIK CHARITABLE FOUNDATION | Charleston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $6.2M | 6 |
| SPECIALIZED ALTERNATIVES FOR FAMILI | Columbia | I20Z Crime & Legal-Related | $6.2M | 5 |
| GROWING HOME SOUTHEAST INC | Cayce | P32 Human Services | $6.2M | 5 |
| CENTER FOR HEIRS' PROPERTY PRESERVATION | North Charleston | I80 Crime & Legal-Related | $6.2M | 4 |
| SOUTH CAROLINA COASTAL CONSERVATION | Charleston | C320 Environment | $6.2M | 5 |
| OCONEE MEMORIAL HOSPITAL FOUNDATION INC | Seneca | E112 Health Care | $6.1M | 0 |
| MOORE FARMS BOTANICAL GARDEN FOUNDATION | Lake City | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $6.1M | 1 |
| TRAIL LIFE USA INC | Belton | O55 Youth Development | $6.1M | 4 |
| TRIDENT UNITED WAY | North Charleston | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $6.1M | 4 |
| UPPER SAVANNAH CARE SERVICES | Greenwood | E70 Health Care | $6.1M | 1 |
| CHEROKEE COUNTY CHARTER SCHOOL | Gaffney | B29 Education | $6.1M | 0 |
| PICKENS CO COMM ON ALCOHOL & DRUG | Pickens | — | $6.1M | 1 |
| FOOTHILLS AREA YMCA | Seneca | P27Z Human Services | $6M | 1 |
| Darlington County Humane Society Inc | Hartsville | D200 Animal-Related | $6M | 0 |
| EXCHANGE CLUB FAIR OF CHARLESTON INC | Ladson | — | $6M | 0 |
| BUCKSPORT WATER SYSTEM INC | Conway | K200 Food, Agriculture & Nutrition | $6M | 1 |
| NATIONAL EDUCATIONAL TELECOMMUNICATIONS | Columbia | A320 Arts, Culture & Humanities | $5.9M | 6 |
| COMPANION FOUNDATION | Charleston | L20 Housing & Shelter | $5.9M | 2 |
| LOWCOUNTRY LAND TRUST INC | Charleston | C340 Environment | $5.9M | 1 |
| WILD DUNES COMMUNITY ASSOCIATION INC | Isle Of Palms | L50 Housing & Shelter | $5.9M | 2 |
| COMPORIUM FOUNDATION INC | Rock Hill | — | $5.9M | 0 |
| RONALD MCDONALD HOUSE CHARITIES OF | Charleston | E86Z Health Care | $5.9M | 2 |
| PALMETTO SCHOLARS ACADEMY | North Charleston | B20 Education | $5.8M | 1 |
| PINEWOOD TRUSTEE INC | Mount Pleasant | — | $5.8M | 0 |
| SOUTH CAROLINA RESEARCH FOUNDATION | Columbia | — | $5.8M | 2 |
| OAKBROOK PREPARATORY SCHOOL | Spartanburg | — | $5.8M | 1 |
| COLUMBIA EMPOWERMENT ZONE INC | Columbia | S30 Community Improvement & Capacity Building | $5.7M | 0 |
| SCOA Cares Inc | Columbia | E86 Health Care | $5.7M | 0 |
| SOUTH CAROLINA TRUCKING ASSOCIATION INC | Columbia | Y34 Mutual & Membership Benefit | $5.7M | 0 |
| NEW FOUNDATIONS HOME FOR CHILDREN | Anderson | P730 Human Services | $5.7M | 0 |
| PALMETTO UTILITY PROTECTION | Columbia | — | $5.6M | 1 |
| THE UNUMB CENTER FOR | Columbia | B28 Education | $5.6M | 0 |
| HOLY TRINITY CLASSICAL CHRISTIAN SCHOOL | Beaufort | B99 Education | $5.6M | 1 |
| NEMOURS PLANTATION WILDLIFE FOUNDATION | Yemassee | D30 Animal-Related | $5.6M | 1 |
| WACCAMAW COMMUNITY FOUNDATION | Murrells Inlet | S11 Community Improvement & Capacity Building | $5.6M | 1 |
| South Carolina Association of Realtors | Columbia | — | $5.6M | 5 |
| GULLAH GEECHEE HISTORIC | Hilton Head Island | — | $5.6M | 0 |
| SAFE HARBOR INC | Greenville | P43 Human Services | $5.6M | 3 |
| HISTORIC CHARLESTON FOUNDATION | Charleston | — | $5.5M | 3 |
| CAMPERDOWN ACADEMY INC | Greenville | B28Z Education | $5.5M | 1 |
| LEAD ACADEMY | Greenville | B25 Education | $5.5M | 0 |
| BRASHIER MIDDLE COLLEGE CHARTER | Simpsonville | B29 Education | $5.5M | 0 |
