| SET FREE ALLIANCE | Greenville | Q33 International, Foreign Affairs & National Security | $3.9M | 1 |
| FRIENDSHIP MEDICAL CLINIC INC | Conway | E210 Health Care | $3.9M | 0 |
| SOUTH CAROLINA NETWORK OF CHILDREN'S | Columbia | O02 Youth Development | $3.9M | 1 |
| Southeastern Chapter National Safety | Irmo | — | $3.9M | 1 |
| SRS COMMUNITY REUSE ORGANIZATION INC | Aiken | S30 Community Improvement & Capacity Building | $3.9M | 2 |
| NUCOR EMPLOYEES CREDIT UNION | Florence | — | $3.9M | 1 |
| BEEMOK FAMILY FOUNDATION | Charleston | B82 Education | $3.9M | 0 |
| Young Men's Christian Association of the Upper Pee Dee Inc | Hartsville | — | $3.9M | 1 |
| GLOBAL ACADEMY OF SOUTH CAROLINA | Spartanburg | — | $3.9M | 0 |
| The Charleston Parks Conservancy | Charleston | C42 Environment | $3.8M | 1 |
| A CHILD'S HAVEN INC | Greenville | — | $3.8M | 1 |
| THE TURTLE SURVIVAL ALLIANCE FOUNDATION | North Charleston | D30 Animal-Related | $3.8M | 2 |
| MIDLANDS TECHNICAL COLLEGE | Columbia | B9XZ Education | $3.8M | 1 |
| CLAYTON KING MINISTRIES | Anderson | X21 Religion-Related | $3.8M | 2 |
| CHILDREN'S PLACE INC | Aiken | — | $3.8M | 0 |
| SOUTHERN EVANGELICAL SEMINARY INC | Rock Hill | — | $3.8M | 1 |
| METANOIA | North Charleston | S31 Community Improvement & Capacity Building | $3.8M | 2 |
| CHILDREN'S MUSEUM OF THE | Greenville | A520 Arts, Culture & Humanities | $3.8M | 0 |
| Edventure Inc | Columbia | A520 Arts, Culture & Humanities | $3.8M | 2 |
| SOUTH CAROLINA ASSOCIATION OF | Columbia | — | $3.8M | 3 |
| The Charleston Museum | Charleston | A540 Arts, Culture & Humanities | $3.8M | 1 |
| The Country Club of Lexington | Lexington | — | $3.8M | 0 |
| PETER B AND ADELINE W RUFFIN FOUNDATION INC | Johns Island | — | $3.7M | 1 |
| SUMTER MUSEUM | Sumter | A540 Arts, Culture & Humanities | $3.7M | 0 |
| SOUTH CAROLINA LIFE AND ACCIDENT AND | Columbia | — | $3.7M | 0 |
| THE REGENSIS INSTITUTE | Spartanburg | S31 Community Improvement & Capacity Building | $3.7M | 1 |
| UNIVERSITY INDUSTRY DEMONSTRATION | Columbia | U01 Science & Technology | $3.7M | 1 |
| COLUMBIA COUNTRY CLUB | Blythewood | — | $3.7M | 0 |
| THE DREAM CENTER OF PICKENS COUNTY | Easley | P85 Human Services | $3.7M | 1 |
| PALMETTO ACADEMY OF LEARNING AND SUCCESS | Myrtle Beach | B29 Education | $3.7M | 1 |
| MIDLANDS STEM CHARTER SCHOOL | Winnsboro | B29 Education | $3.6M | 1 |
| LOWCOUNTRY CENTER FOR VETERANS | Charleston | H05 Medical Research | $3.6M | 8 |
| Easter Seal Society of South Carolina | Columbia | — | $3.6M | 6 |
| UNITED MINISTRIES | Greenville | X21Z Religion-Related | $3.6M | 1 |
| PEE DEE LAND TRUST | Florence | C34 Environment | $3.6M | 1 |
| Carolina Crown INC | Fort Mill | — | $3.6M | 1 |
| PETS INC THE CAROLINAS HUMANE SOCIETY | West Columbia | D200 Animal-Related | $3.6M | 2 |
| NATIONAL ASSOCIATION FOR CAMPUS | Columbia | — | $3.6M | 3 |
| DANNY & RONS RESCUE | Rembert | D20 Animal-Related | $3.6M | 1 |
| FRONT PORCH HOUSING | Greenville | L21 Housing & Shelter | $3.6M | 0 |
| ANDERSON FREE CLINIC | Anderson | E32Z Health Care | $3.6M | 1 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B012 Education | $3.6M | 1 |
| Palmetto Care Connections | Bamberg | E99 Health Care | $3.6M | 4 |
| CHARLESTON REDEVELOPMENT | Charleston | S31 Community Improvement & Capacity Building | $3.5M | 1 |
| NUTRAMAX FAMILY FOUNDATION | Lancaster | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| NATIONAL GOLF COURSE OWNERS ASSOCIATION | Charleston | — | $3.5M | 3 |
| SANTEE LYNCHES AFFORDABLE HOUSING | Sumter | L21Z Housing & Shelter | $3.5M | 0 |
| PIEDMONT CARE INC | Spartanburg | E80 Health Care | $3.5M | 1 |
| GARNET TRUST FOUNDATION | Columbia | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| CHARLESTON STAGE COMPANY INC | Charleston | A650 Arts, Culture & Humanities | $3.5M | 3 |
