| INTERLAKEN WILDLIFE FOUNDATION | Cameron | D30 Animal-Related | $856k | 0 |
| WHIPPOORWILL COMMUNITY PARK INC | Fort Mill | N31 Recreation & Sports | $855k | 0 |
| HARVEST CHRISTIAN MINISTRIES INC | Abbeville | P99 Human Services | $851k | 0 |
| GREATER SUMMERVILLEDORCHESTER COUN | Summerville | — | $850k | 0 |
| PALMETTO REGION VOLLEYBALL ASS | Ninety Six | — | $850k | 6 |
| PUBLIC EDUCATION PARTNERS GREENVILLE COUNTY | Greenville | B20A Education | $849k | 1 |
| GREATER FLORENCE CHAMBER OF COMMERCE | Florence | — | $849k | 1 |
| COLUMBIA JEWISH FEDERATION | Columbia | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $848k | 0 |
| MCGUINN HOMES FOUNDATION | Lexington | Q33 International, Foreign Affairs & National Security | $848k | 0 |
| SOUTH CAROLINA STATE FIREFIGHTERS' FOUNDATION | Columbia | B82 Education | $844k | 0 |
| APPALACHIAN DEVELOPMENT CORPORATION | Greenville | — | $843k | 1 |
| UNITED WAY OF THE LAKELANDS | Greenwood | — | $841k | 1 |
| GREENWOOD PATHWAY HOUSE FOUNDATION | Greenwood | T40 Philanthropy, Voluntarism & Grantmaking Foundations | $840k | 0 |
| The American Legion Dept of SC | Columbia | — | $840k | 2 |
| FRESH FUTURE FARM INC | Charleston | K99 Food, Agriculture & Nutrition | $839k | 1 |
| CROSS OUTREACH MINISTRIES INC | Bluffton | X192 Religion-Related | $839k | 0 |
| Blue Ribbon Schools of Excellence | Chapin | B129 Education | $839k | 1 |
| TRUST UW OF HC GRAHAM | Mullins | — | $837k | 1 |
| Coker University Foundation | Hartsville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $837k | 0 |
| ABUNDANCE CAPITAL | Greenville | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $837k | 2 |
| York County Regional Chamber of Commerce | Rock Hill | — | $836k | 2 |
| South Carolina Physicians Care Charity Inc | Chapin | — | $836k | 6 |
| MACEDONIA FIRE DISTRICT | Gaffney | M24 Public Safety, Disaster Preparedness & Relief | $835k | 0 |
| SOUTH CAROLINA NATIONAL HERITAGE CORRIDOR | Belton | A80 Arts, Culture & Humanities | $835k | 1 |
| HF HELP CORPORATION | Ladson | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $835k | 0 |
| THE GOODCOIN GIVING FUND | Charleston | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $832k | 0 |
| UNIVERSITY OF SOUTH CAROLINA BEAUFORT EDUCATION FOUNDATION | Bluffton | B11 Education | $832k | 0 |
| Carols Hope for Childhood Cancer Inc | Spartanburg | P20 Human Services | $832k | 0 |
| UWS PROPERTIES INC | Greenville | S47 Community Improvement & Capacity Building | $832k | 0 |
| OUR UPSTATE SC | Greenville | S99 Community Improvement & Capacity Building | $831k | 1 |
| LOWCOUNTRY BIBLICAL COUNSELING CENTER | Charleston | F60 Mental Health & Crisis Intervention | $829k | 0 |
| GVW VOLUNTEER FIRE DEPARTMENT IN | Graniteville | M24 Public Safety, Disaster Preparedness & Relief | $829k | 0 |
| VETERANS WELCOME HOME AND RESOURCE CENTER | Little River | W30 Public & Societal Benefit | $827k | 1 |
| BEAUFORT COUNTY ECONOMIC DEVELOPMENT CORPORATION | Hilton Head Island | S30 Community Improvement & Capacity Building | $827k | 1 |
| SHRINERS INTERNATIONAL OMAR SHRINERS | Mount Pleasant | — | $826k | 0 |
| KERSHAW COUNTY COUNCIL ON AGING | Camden | P81Z Human Services | $825k | 0 |
| THE WLT FOUNDATION | Greenville | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $825k | 0 |
| FIRE PIT RANCH | Moore | O50 Youth Development | $825k | 2 |
| CAROLINA PREGNANCY CENTER | Spartanburg | E400 Health Care | $822k | 1 |
| WACCAMAW YOUTH CENTER INC | Conway | — | $821k | 1 |
| FRIENDS OF THE AIKEN CO PUBLIC LIBRARY | Aiken | — | $820k | 0 |
| TCM ENTERPRISES LLC | Greenville | — | $820k | 0 |
| COLUMBIA POST OFFICE CREDIT UNION | Columbia | — | $819k | 0 |
| SOUTHEAST AFFORDABLE HOUSING ADMINISTRATION | Greenville | L21 Housing & Shelter | $816k | 1 |
| SOUTH CAROLINA ASSOCIATION OF PUBLIC CHARTER SCHOOLS | Columbia | B990 Education | $814k | 1 |
| CHARLESTON YACHT CLUB | Charleston | — | $813k | 0 |
| SENIOR CENTERS OF CHEROKEE COUNTY | Gaffney | P81Z Human Services | $812k | 0 |
| CHADSWORTH DRIVE SWIM CLUB INC | Greenville | N50 Recreation & Sports | $812k | 0 |
| Neighbors Together Inc | North Charleston | P20Z Human Services | $811k | 1 |
| SHRINERS INTERNATIONAL JAMIL SHRINERS | Columbia | — | $810k | 0 |
