| WYOMING OUTDOOR COUNCIL | Lander | C016 Environment | $2.7M | 1 |
| HOME VENTILATING INSTITUTE INC | Cheyenne | — | $2.7M | 7 |
| PODER ACADEMY SECONDARY SCHOOL | Cheyenne | B29 Education | $2.7M | 2 |
| SUBLETTE CENTER | Pinedale | — | $2.7M | 2 |
| Natrona County Meals on Wheels Inc | Casper | P81Z Human Services | $2.7M | 1 |
| MOUNTAIN REGIONAL SERVICES INC | Evanston | P730 Human Services | $2.7M | 1 |
| NATIONAL MUSEUM OF MILITARY VEHICLES | DuBois | A50 Arts, Culture & Humanities | $2.7M | 1 |
| REACH FOUNDATION | Riverton | L21Z Housing & Shelter | $2.7M | 0 |
| COMMUNITY ACTION OF LARAMIE COUNTY INC | Cheyenne | P20Z Human Services | $2.7M | 3 |
| FRONTIER SCHOOL OF THE BIBLE | LaGrange | B41Z Education | $2.7M | 1 |
| FREMONT COUNSELING SERVICE INC | Lander | F32Z Mental Health & Crisis Intervention | $2.7M | 3 |
| EBOR CHARITABLE TRUST | Jackson | P99 Human Services | $2.6M | 1 |
| THE NEW MUSEUM AT THE BRADFORD BRINTON RANCH | Big Horn | A51 Arts, Culture & Humanities | $2.6M | 2 |
| JACKSON HOLE CHAMBER OF COMMERCE | Jackson | — | $2.6M | 1 |
| ANDERSON DONOR ADVISED CHARITABLE FUND | Cheyenne | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 0 |
| Wyoming Independent Living Inc | Casper | P8XZ Human Services | $2.5M | 0 |
| WYOMING SENIOR CITIZENS INC | Riverton | P81Z Human Services | $2.5M | 1 |
| Serve Wyoming Inc | Casper | T40 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 0 |
| CHEYENNE CARRIAGE COLLECTION | Cheyenne | A23 Arts, Culture & Humanities | $2.5M | 1 |
| LARAMIE PLAINS MUSEUM ASSOCIATION INC | Laramie | A540 Arts, Culture & Humanities | $2.5M | 0 |
| WOLD FOUNDATION | Casper | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 0 |
| CHEYENNE REGIONAL MEDICAL CENTER FOUNDATION | Cheyenne | E60 Health Care | $2.5M | 2 |
| AMERICAN CHAMBER OF COMMERCE IN UKRAINE INC | Cody | S41 Community Improvement & Capacity Building | $2.4M | 1 |
| VISION BEYOND BORDERS INC | Casper | X21 Religion-Related | $2.4M | 1 |
| TETON RAPTOR CENTER | Wilson | — | $2.4M | 2 |
| WYOMING HOUSING NETWORK INC | Casper | L20 Housing & Shelter | $2.4M | 1 |
| BUFFALO SENIOR CENTER INC | Buffalo | — | $2.4M | 1 |
| TETON LITERACY CENTER | Jackson | B92Z Education | $2.4M | 1 |
| YOUNG AT HEART SENIOR CITIZENS CENTER | Rock Springs | P81Z Human Services | $2.4M | 1 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS LOCAL UNION 322 | Casper | — | $2.4M | 10 |
| WYOMING HOSPITAL ASSOCIATION | Cheyenne | — | $2.4M | 3 |
| MARY H STORER FOUNDATION | Cheyenne | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $2.4M | 5 |
| KCCF CHARITABLE TRUST II | Cheyenne | X22 Religion-Related | $2.3M | 0 |
| FOSTER'S OUTRIDERS FOUNDATION | Jackson | R60 Civil Rights, Social Action & Advocacy | $2.3M | 1 |
| CONVERSE COUNTY AGING SERVICES | Douglas | P81Z Human Services | $2.3M | 0 |
| JOE AND ARLENE WATT FOUNDATION INC | Sheridan | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.3M | 0 |
| THE KINDNESS RANCH ANIMAL SANCTUARY | Hartville | D20 Animal-Related | $2.3M | 3 |
| DIVERSIFIED SERVICES INC | Torrington | J30Z Employment | $2.3M | 1 |
| HEART MOUNTAIN WYOMING FOUNDATION | Powell | A80 Arts, Culture & Humanities | $2.3M | 0 |
| KARL M JOHNSON FOUNDATION | Jackson | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 3 |
| WYOMING SCHOOL BOARDS ASSOCIATION | Cheyenne | — | $2.2M | 4 |
| NION ROBERT THIERIOT FOUNDATION | Elk Mountain | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 2 |
| DOG IS MY COPILOT | Jackson | D20 Animal-Related | $2.2M | 1 |
| DANCERS WORKSHOP | Jackson | A6E0 Arts, Culture & Humanities | $2.2M | 1 |
| STAR VALLEY RANCH ASSOCIATION | Star Valley Ranch | — | $2.2M | 1 |
| NORTHWEST COLLEGE FOUNDATION | Powell | — | $2.1M | 0 |
| MEALS ON WHEELS OF CHEYENNE INC | Cheyenne | K36Z Food, Agriculture & Nutrition | $2.1M | 1 |
| UKRAINE FREEDOM FUND | Afton | M12 Public Safety, Disaster Preparedness & Relief | $2.1M | 0 |
| CAMPBELL COUNTY SENIOR CITIZENS ASSOCIATION | Gillette | P81 Human Services | $2.1M | 1 |
| JACKSON HOLE HISTORICAL SOCIETY AND MUSEUM | Jackson | — | $2.1M | 0 |
